We present methods based on Optical Coherence Tomography to quantify longitudinal changes in murine cortical vasculature. To demonstrate our methods, we tracked age-related changes in vascular structure and function of 3xTg Alzheimer’s disease (AD) and age-matched wild-type (WT) mice over the course of 7 months. In total, we measured 27 longitudinal parameters related to the morphology, topology, and function of the cortical vasculature across all scales: large pial vessels, penetrating vessels, and capillaries. Ten of these parameters showed different time-courses between AD and WT mice, with significant alterations preceding the onset of cognitive decline.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.