Longitudinal tracking of vascular properties in Alzheimer's disease using optical coherence tomography

Sabina Stefan; Konrad Walek; Jang-Hoon Lee; Pooja Puttigampala; Anna Kim; Seong-Wook Park; Jonghwan Lee

doi:10.1117/12.2607605

7 March 2022 Longitudinal tracking of vascular properties in Alzheimer's disease using optical coherence tomography

Sabina Stefan, Konrad Walek, Jang-Hoon Lee, Pooja Puttigampala, Anna Kim, Seong-Wook Park, Jonghwan Lee

Author Affiliations +

Proceedings Volume PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI; PC1194803 (2022) https://doi.org/10.1117/12.2607605
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We present methods based on Optical Coherence Tomography to quantify longitudinal changes in murine cortical vasculature. To demonstrate our methods, we tracked age-related changes in vascular structure and function of 3xTg Alzheimer’s disease (AD) and age-matched wild-type (WT) mice over the course of 7 months. In total, we measured 27 longitudinal parameters related to the morphology, topology, and function of the cortical vasculature across all scales: large pial vessels, penetrating vessels, and capillaries. Ten of these parameters showed different time-courses between AD and WT mice, with significant alterations preceding the onset of cognitive decline.

Conference Presentation

Citation Download Citation

Sabina Stefan, Konrad Walek, Jang-Hoon Lee, Pooja Puttigampala, Anna Kim, Seong-Wook Park, and Jonghwan Lee "Longitudinal tracking of vascular properties in Alzheimer's disease using optical coherence tomography", Proc. SPIE PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, PC1194803 (7 March 2022); https://doi.org/10.1117/12.2607605

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