Development of an ssDNA aptamer-based electrochemical biosensor for SARS-CoV-2 Omicron detection in saliva (Conference Presentation)

Geisianny Moreira; Shoumen P. A. Datta; Diana Vanegas; Eric S. McLamore

doi:10.1117/12.2663105

14 June 2023 Development of an ssDNA aptamer-based electrochemical biosensor for SARS-CoV-2 Omicron detection in saliva (Conference Presentation)

Geisianny Moreira, Shoumen P. A. Datta, Diana Vanegas, Eric S. McLamore

Author Affiliations +

Proceedings Volume PC12548, Smart Biomedical and Physiological Sensor Technology XX; PC1254802 (2023) https://doi.org/10.1117/12.2663105
Event: SPIE Defense + Commercial Sensing, 2023, Orlando, Florida, United States

Abstract

We present a cost-affordable capacitive aptasensor specific to Omicron variant of SARS-CoV-2. Laser-induced graphene (LIG) electrodes were used as transducer surfaces due to their performance and facile and low-cost production. Electrochemical impedance spectroscopy (EIS) was applied as signal transduction for biosensing studies of Omicron variant of SARS-CoV-2 and non-target viruses by aptasensor. At lower viral load, the aptasensor showed to be sensitive and specific for Omicron. At higher viral load, aptasensor is not able to differentiate between target and non-target viruses. The proposed biosensor showed promise for detecting Omicron variant of SARS-CoV-2 during early infection stage when concentration of intact virion is low.

Conference Presentation

Citation Download Citation

Geisianny Moreira, Shoumen P. A. Datta, Diana Vanegas, and Eric S. McLamore "Development of an ssDNA aptamer-based electrochemical biosensor for SARS-CoV-2 Omicron detection in saliva (Conference Presentation)", Proc. SPIE PC12548, Smart Biomedical and Physiological Sensor Technology XX, PC1254802 (14 June 2023); https://doi.org/10.1117/12.2663105

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