Evolving antidepressant: from SSRIs to psychedelic

Hanyang Hong

doi:10.1117/12.2691868

7 September 2023 Evolving antidepressant: from SSRIs to psychedelic

Hanyang Hong

Proceedings Volume 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023); 127892R (2023) https://doi.org/10.1117/12.2691868
Event: International Conference on Modern Medicine and Global Health (ICMMGH 2023), 2023, Oxford, United Kingdom

Abstract

SSRIs mediate antidepressant effects by inhibiting specific serotonin transport(SERT) and subsequent modulation of serotonin levels in the brain. This review paper provides an overview of the mechanisms of action of selective serotonin reuptake inhibitors (SSRIs), as well as psychedelics, including their potential therapeutic applications in treating psychiatric disorders. By examining the limitations of current antidepressant treatments and highlighting the need for alternative approaches, it is necessary to explore the working mechanisms of psychedelic substances, including interaction with various receptors and neural networks in the brain and their potential role in promoting neuroplasticity, which may facilitate a reset of maladaptive neural pathways and promote new patterns of neural connectivity, potentially leading to improved mental health outcomes. Recent research on psychoplastogens, non-hallucinogenic analogs of psychedelic substances, may offer a promising alternative to traditional psychedelic therapies, including the reduced potential for adverse effects while promoting neuroplasticity, potentially improving mental health outcomes.

Citation Download Citation

Hanyang Hong "Evolving antidepressant: from SSRIs to psychedelic", Proc. SPIE 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023), 127892R (7 September 2023); https://doi.org/10.1117/12.2691868

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