Hazardous materials transportation is different from general materials transportation which needs special transport route. In this article, the safe transportation route planning (STRP) for vehicles loaded with hazardous materials is studied. When the transport time is an uncertain parameter, the dependent-chance objective programming model of STRP is established, and the mixed algorithm combining genetic algorithm and simulation technology is proposed to resolve the model. Moreover, the feasibility of model and algorithm is verified by an example. The research results have certain valuable reference in some respects such as reducing transportation risk and ensuring transportation safety for hazardous materials
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