Dr. Yusi Miao Profile

Dr. Yusi Miao

Postdoctoral Fellow

SPIE Involvement:

Author

Publications (26)

SPIE Journal Paper | 14 May 2024 Open Access

Generalized 3D registration algorithm for enhancing retinal optical coherence tomography images

Tiffany Tse, Yudan Chen, Mahsa Siadati, Yusi Miao, Jun Song, Da Ma, Zaid Mammo, Myeong Jin Ju

JBO, Vol. 29, Issue 06, 066002, (May 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.6.066002

KEYWORDS: Optical coherence tomography, Image registration, 3D image processing, Visualization, Imaging systems, Algorithm development, Image quality, Eye, Detection and tracking algorithms, Signal to noise ratio

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SignificanceOptical coherence tomography (OCT) has emerged as the standard of care for diagnosing and monitoring the treatment of various ocular disorders due to its noninvasive nature and in vivo volumetric acquisition capability. Despite its widespread applications in ophthalmology, motion artifacts remain a challenge in OCT imaging, adversely impacting image quality. While several multivolume registration algorithms have been developed to address this issue, they are often designed to cater to one specific OCT system or acquisition protocol.AimWe aim to generate an OCT volume free of motion artifacts using a system-agnostic registration algorithm that is independent of system specifications or protocol.ApproachWe developed a B-scan registration algorithm that removes motion and corrects for both translational eye movements and rotational angle differences between volumes. Tests were carried out on various datasets obtained from two different types of custom-built OCT systems and one commercially available system to determine the reliability of the proposed algorithm. Additionally, different system specifications were used, with variations in axial resolution, lateral resolution, signal-to-noise ratio, and real-time motion tracking. The accuracy of this method has further been evaluated through mean squared error (MSE) and multiscale structural similarity index measure (MS-SSIM).ResultsThe results demonstrate improvements in the overall contrast of the images, facilitating detailed visualization of retinal vasculatures in both superficial and deep vasculature plexus. Finer features of the inner and outer retina, such as photoreceptors and other pathology-specific features, are discernible after multivolume registration and averaging. Quantitative analyses affirm that increasing the number of averaged registered volumes will decrease MSE and increase MS-SSIM as compared to the reference volume.ConclusionsThe multivolume registered data obtained from this algorithm offers significantly improved visualization of the retinal microvascular network as well as retinal morphological features. Furthermore, we have validated that the versatility of our methodology extends beyond specific OCT modalities, thereby enhancing the clinical utility of OCT for the diagnosis and monitoring of ocular pathologies.

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Proceedings Article | 13 March 2024 Poster

Numerical correction of bi-directional scanning distortion in FDML OCT

Mohammad Shahidul Islam, Yusi Miao, Myeong Jin Ju

Proceedings Volume PC12830, PC128301N (2024) https://doi.org/10.1117/12.3005753

KEYWORDS: Optical coherence tomography, Distortion, Tissue optics, Tissues, Medical diagnostics, Laser sources, Interferograms, Galvanometers, Fourier transforms, Data acquisition

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Proceedings Article | 13 March 2024 Presentation

Digital adaptive optics with phase bias correction for bidirectional OCT scanning

Destiny Hsu, Jun Song, Yusi Miao, Shuichi Makita, Yoshiaki Yasuno, Orson Moritz, Marinko Sarunic, Myeong Jin Ju

Proceedings Volume PC12830, PC128300Q (2024) https://doi.org/10.1117/12.3005590

KEYWORDS: Optical signal processing, Optical coherence tomography, Bias correction, Adaptive optics, Galvanometers, Data acquisition, Wavefronts, Wavefront aberrations, Scanners, Retinal scanning

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Proceedings Article | 11 August 2023 Paper

Melanin migration in retinitis pigmentosa evaluated by ultra-wide-field polarization diversity optical coherence tomography

Yusi Miao, Shuibin Ni, Jun Song, Yifan Jian, Myeong Jin Ju

Proceedings Volume 12632, 1263206 (2023) https://doi.org/10.1117/12.2670622

KEYWORDS: Optical coherence tomography, Polarization, Imaging systems, Diseases and disorders, Visualization, Scanners, Retina, Photography, Multimodal imaging, Genetics

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Proceedings Article | 11 August 2023 Paper

Multi-modal functional sensorless adaptive optics for small animal retinal imaging

Jun Song, Yusi Miao, Joanne Matsubara, Marinko Sarunic, Myeong Jin Ju

Proceedings Volume 12632, 126320N (2023) https://doi.org/10.1117/12.2670968

KEYWORDS: Animals, Retinal scanning, Adaptive optics, Retinal diseases, Animal model studies, Visualization, Visual process modeling, Scanning laser ophthalmoscopes, Optical scanning systems, Optical coherence tomography

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Proceedings Article | 17 March 2023 Presentation

Deep learning-based assessment of acute respiratory distress syndrome (ARDS) using optical coherence tomography (OCT)

Raksha Sreeramachandra Murthy, Yusi Miao, Li-Dek Chou, Andriy Batchinsky, Zhongping Chen

Proceedings Volume 12354, 123540K (2023) https://doi.org/10.1117/12.2670002

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Proceedings Article | 17 March 2023 Presentation

Wide-field 400-khz polarization diversity optical coherence tomography imaging of retinal pigment epithelium melanin loss in retinitis pigmentosa

Yusi Miao, Khaldon Abbas, Destiny Hsu, Jun Song, Hoyoung Jung, Eduardo Navajas, Myeong Jin Jin

Proceedings Volume PC12360, PC1236013 (2023) https://doi.org/10.1117/12.2650439

KEYWORDS: Coherence imaging, Optical coherence tomography, Polarization, Retinal scanning, Optical imaging, Vertical cavity surface emitting lasers, Rods, Retina, Prototyping, Photography

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Proceedings Article | 10 March 2023 Presentation

Sensorless adaptive optics multi-modal functional small animal imaging for age-related macular degeneration mouse model

Jun Song, Yusi Miao, Destiny Hsu, Joanne Matsubara, Marinko Sarunic, Myeong Jin Ju

Proceedings Volume PC12367, PC123671G (2023) https://doi.org/10.1117/12.2652663

KEYWORDS: Mouse models, Sensors, Adaptive optics, Preclinical imaging, Visualization, Imaging systems, Data modeling, Visual process modeling, Scanning laser ophthalmoscopes, Retinal scanning

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Proceedings Article | 7 March 2022 Presentation

Robust multi-volume 3D registration of optical coherence tomography (OCT) volumes

SeyedehMahsa Siadatifini, Yusi Miao, Arman Athwal, Da Ma, Mirza Faisal Beg, Marinko Sarunic, Myeong Jin Ju

Proceedings Volume PC11948, PC119481C (2022) https://doi.org/10.1117/12.2612385

KEYWORDS: Optical coherence tomography, 3D image processing, Image registration, Detection and tracking algorithms, 3D acquisition, Visualization, Optical resolution, Image resolution, Image processing, Head

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Proceedings Article | 7 March 2022 Presentation

Early detection of acute respiratory distress syndrome (ARDS) using optical coherence tomographic (OCT) images by deep learning

Raksha Sreeramachandra Murthy, Yusi Miao, Li-Dek Chou, Andriy Batchinsky, Zhongping Chen

Proceedings Volume 11937, 1193703 (2022) https://doi.org/10.1117/12.2610545

KEYWORDS: Optical coherence tomography, Tomography, Injuries, Coherence (optics), Lung, Diagnostics, Convolutional neural networks

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Proceedings Article | 7 March 2022 Presentation

Numerical spectral calibration for dual spectrometer SD-OCT

Jun Song, Yusi Miao, Mahsa Siadati, Marinko Sarunic, Yifan Jian, Myeong Jin Ju

Proceedings Volume PC11948, PC1194811 (2022) https://doi.org/10.1117/12.2610708

KEYWORDS: Spectroscopy, Optical coherence tomography, Spectral calibration, Calibration, Numerical analysis, Optical components, Optical alignment, Ophthalmology, Mirrors, In vivo imaging

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Proceedings Article | 5 March 2021 Presentation

Effective scanning protocol for optical coherence tomography and angiography using a 1.6 MHz Fourier domain mode-locked laser source

Destiny Hsu, Ji Hoon Kwon, Arman Athwal, Yusi Miao, Yifan Jian, Marinko Sarunic, Myeong Jin Ju

Proceedings Volume 11630, 116301L (2021) https://doi.org/10.1117/12.2578207

KEYWORDS: Optical coherence tomography

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Proceedings Article | 5 March 2021 Presentation

Wide-field mapping of upper airway cilia dynamics using spectrally encoded interferometric microscopy

Zhikai Zhu, Jason Chen, Yusi Miao, David Mukai, George Philipopoulos, Melina Doosty, Jangwoen Lee, Sari Mahon, Matthew Brenner, Brian J. Wong, Zhongping Chen

Proceedings Volume 11627, 1162708 (2021) https://doi.org/10.1117/12.2578007

KEYWORDS: Microscopy, Interferometry, Doppler effect, Visualization, Wave propagation, Viruses, Spatial resolution, Pathogens, Particles, Optical imaging

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Proceedings Article | 5 March 2021 Presentation

In-vivo analysis of acute chlorine gas inhalation injury using optical coherence tomography (OCT) in rabbit model

Zhikai Zhu, Yusi Miao, George Philipopoulos, Melody Doosty, Wenqi He, Jianing Tang, Jangwoen Lee, David Mukai, Fengyi Zhang, Saijun Qiu, Jing Cao, Xiao Gao, Sari Mahon, Livia Veress, Matthew Brenner, Carl White, Zhongping Chen

Proceedings Volume 11620, 1162007 (2021) https://doi.org/10.1117/12.2577927

KEYWORDS: Optical coherence tomography, Injuries, Chlorine gas, In vivo imaging, Tissues, Imaging systems, Vertical cavity surface emitting lasers, Bronchoscopy, Visualization, Diagnostics

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Proceedings Article | 10 March 2020 Presentation

Fast measurement of reflection matrix for deep imaging in highly scattering media based on optical coherence tomography (Conference Presentation)

Jing Cao, Qiang Yang, Yusi Miao, Tiancheng Huo, Yan Li, Youmin He, Jiang Zhu, Zhongping Chen

Proceedings Volume 11253, 112530H (2020) https://doi.org/10.1117/12.2545511

KEYWORDS: Optical coherence tomography, Scattering media, Light scattering, Biomedical optics, Scattering, Phase shifts, Multiple scattering, Tissue optics, Reconstruction algorithms, Image restoration

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Proceedings Article | 9 March 2020 Presentation

Full-vectorial characterization of complex femtosecond laser pulses (Conference Presentation)

Tiancheng Huo, Li Qi, Yusi Miao, Yan Li, Zhongping Chen

Proceedings Volume 11270, 112700J (2020) https://doi.org/10.1117/12.2547002

KEYWORDS: Femtosecond phenomena, Polarization, Electroluminescent displays, 3D metrology, Interferometers, Charge-coupled devices, Optical filters, Light wave propagation, Pulsed laser operation, Free space

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Proceedings Article | 6 March 2020 Presentation + Paper

Assessment of toxin-induced airway injury and therapeutic effects in a rat model by optical coherence tomography

Ryan Cheung, Yusi Miao, Andy Choi, Carl White, Matthew Brenner, Zhongping Chen

Proceedings Volume 11213, 112130G (2020) https://doi.org/10.1117/12.2546356

KEYWORDS: Image segmentation, Optical coherence tomography, 3D modeling, Neural networks, Data modeling, Biomedical optics, Convolutional neural networks, Injuries, Machine vision, Computer vision technology

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Proceedings Article | 6 March 2020 Presentation

Handheld intravaginal OCT endoscope for in-situ monitoring of laser vaginal ablation (Conference Presentation)

Yusi Miao, Neha Sudol, Xiaoming Hu, Yan Li, Joseph Jing, Yona Tadir, Felicia Lane, Zhongping Chen

Proceedings Volume 11214, 112140K (2020) https://doi.org/10.1117/12.2546294

KEYWORDS: Laser ablation, Optical coherence tomography, Endoscopes, Laser therapeutics, Global system for mobile communications, Laser tissue interaction, Safety, Laser development, Angiography, Endoscopy

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Proceedings Article | 13 March 2019 Presentation

Multidimensional structures of intrinsically controlled complex laser pulses (Conference Presentation)

Tiancheng Huo, Li Qi, Yusi Miao, Zhonglie Piao, Buyun Zhang, Yan Li, Zhongping Chen

Proceedings Volume 10897, 108971K (2019) https://doi.org/10.1117/12.2510800

KEYWORDS: Fiber lasers, Pulsed laser operation, Polarization, Multimode fibers, Femtosecond phenomena, Electroluminescent displays, 3D metrology, Interferometers, Paraxial approximations, Light wave propagation

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Laser pulses in either laboratory or industry are typically complex objects. Unlike the classical electro-magnetic wave with uniform polarization distribution along the flat wave-front or a general vector beam under the paraxial approximation, the real light pulses, such as the pulses from the high power multimode fiber laser and the dechirped femtosecond pulses with structured wave-front, spectrum and polarization distributions, usually have non-vanishing component in the propagation direction. Therefore, the description of a general vectorial laser pulse should be implemented in multi-dimensional way, for the light is the combination of a three-dimensional(3D) vector field (electric ﬁeld E) and a 3D pseudovector field (magnetic ﬁeld B) in the 3D Euclidean space (R3). Here we report on a novel technique for the multi-dimensional characterization which includes the spatiotemporal amplitude and phase information as well as the vectorial features in 3D Euclidean space of the complex laser pulses, such as the intrinsically controlled femtosecond pulses with higher-order Poincaré sphere beams and vectoral spherical beams. A two-steps-based polarization-sensitive Mach–Zehnder interferometer temporal scan technique was used, at the first time, to capture the complete information of the pulses. The corresponding measurement device, placed on the collimated and attenuated beam at the laser output is consists of a special Mach–Zehnder interferometer, a polarizing beam-splitter and charge-coupled device (CCD) cameras. The reference beam with vertical and horizontal polarization is exported from the cavity and attenuated to a suitable intensity by using a neutral-density filter. After 3D phase unwrapping, removal of the reference curvature, correction of achromatic wave-front distortions, spectral phase and amplitude reconstructions, as well as the measurement for the intrinsic phase of the reference pulse, the complete information of the pulse, include the phase information of the three electronic components, will be obtained. This new measurement capability opens the way to in-depth characterizations and optimizations of the complex laser pulses and ultimately to the study of new phenomena of multimode fiber laser generated laser pulse as well as the interactions between materials and structured ultra-short laser beams.

Proceedings Article | 14 March 2018 Presentation

Femtosecond laser with intracavity controlled higher-order Poincaré sphere beams and total E-field reconstruction of the pulses (Conference Presentation)

Tiancheng Huo, Li Qi, Yusi Miao, Zhonglie Piao, Buyun Zhang, Jiang Zhu, Yan Li, Zhongping Chen

Proceedings Volume 10549, 105490G (2018) https://doi.org/10.1117/12.2289365

KEYWORDS: Femtosecond phenomena, Polarization, Poincaré sphere, Interferometers, Mode locking, Optical filters, Superposition, Light sources, Fiber lasers, Diffraction gratings

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Light carries both spin and orbital angular momentum and the superpositions of these two dynamical properties have found many applications. Many techniques exist to create such light sources but none allow their creation at the femtosecond laser. Here we report on a novel mode-locked ytterbium-doped fiber laser that generates femtosecond pulses with higher-order Poincaré sphere beams. The controlled generation of such pulses such as azimuthally and radially polarized light with definite orbital angular momentum modes are demonstrated. A unidirectional ring cavity constructed with the Yb-doped fiber placed at the end of the fiber section to reduces unnecessary nonlinear effects is employed for self-starting operation. Two pairs of diffraction gratings are used for compensating the normal group velocity dispersion of the fiber and other elements. Mode-locked operation is achieved based on nonlinear polarization evolution, which is mainly implemented with the single mode fiber, the bulk wave plates and the variable spiral plates (q-plate with topological charge q=0.5). The conversion from spin angular momentum to the OAM and reverse inside the laser cavity are realized by means of a quarter-wave plate and a q-plate so that the polarization control was mapped to OAM mode control. To demonstrate the total spatiotemporal and vectoral characterization of the new type femtosecond laser beams, here, a polarization-sensitive Mach–Zehnder interferometer temporal scan technique was used, at the first time, to capture the complete information of the pulse. The corresponding measurement device, placed on the collimated and attenuated beam at the laser output and simply consists of a special Mach–Zehnder interferometer, a polarizing beam-splitter and two charge-coupled device (CCD) cameras. The reference beam with vertical polarization is exported from the cavity and attenuated to a suitable intensity by using a neutral-density filter. After Fourier filtering, removal of the reference curvature, correction of achromatic wave-front distortions, spectral phase and amplitude reconstructions, as well as the measurement for the intrinsic phase of the reference pulse, the complete information of the pulse will be obtained. This new measurement capability opens the way to in-depth characterization and optimization of the vector vortex femtosecond laser pulse and ultimately to the detection of new phenomena of the interactions between materials and structured femtosecond laser beams in space–time and polarization.

Proceedings Article | 14 March 2018 Presentation

Automated 3D reconstruction and evaluation of methyl isocyanate-induced airway injury in a rat model using a miniature optical coherence endoscopy probe (Conference Presentation)

Yusi Miao, Joseph Jing, Vineet Desai, Yueqiao Qu, Jacqueline Rioux, Rhonda Garlick, Livia Veress, Sari Mahon, Matthew Brenner, Carl White, Zhongping Chen

Proceedings Volume 10470, 104700E (2018) https://doi.org/10.1117/12.2287289

KEYWORDS: Endoscopy, Optical coherence tomography, 3D modeling, Industrial chemicals, Animal model studies, Injuries, Coherence (optics), Image segmentation, 3D image processing, Stereoscopy

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Proceedings Article | 24 April 2017 Presentation

Longitudinally polarized shear wave optical coherence elastography (Conference Presentation)

Yusi Miao, Jiang Zhu, Li Qi, Yueqiao Qu, Youmin He, Yiwei Gao, Zhongping Chen

Proceedings Volume 10067, 1006703 (2017) https://doi.org/10.1117/12.2248486

KEYWORDS: Medical laser equipment, Optical testing, Elastography, Wave propagation, Near field optics, Tissue optics, Coherence (optics), Transducers, Tissues, 3D modeling

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Proceedings Article | 24 April 2017 Presentation

Quantitative analysis of retina layer elasticity based on automatic 3D segmentation (Conference Presentation)

Youmin He, Yueqiao Qu, Yi Zhang, Teng Ma, Jiang Zhu, Yusi Miao, Mark Humayun, Qifa Zhou, Zhongping Chen

Proceedings Volume 10067, 100670C (2017) https://doi.org/10.1117/12.2251085

KEYWORDS: Tissue optics, Medical laser equipment, Retina, Signal detection, Image segmentation, Image quality, Image analysis, Image processing algorithms and systems, Quantitative analysis, Eye

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Proceedings Article | 19 April 2017 Presentation

Quantified elasticity mapping of ocular tissue using acoustic radiation force optical coherence elastography (Conference Presentation)

Yueqiao Qu, Youmin He, Yi Zhang, Teng Ma, Jiang Zhu, Yusi Miao, Cuixia Dai, Ronald Silverman, Mark Humayun, Qifa Zhou, Zhongping Chen

Proceedings Volume 10053, 1005321 (2017) https://doi.org/10.1117/12.2250439

KEYWORDS: Tissue optics, Tissues, Acoustics, Coherence (optics), Elastography, Signal detection, Retina, Eye, Medical laser equipment, Laser applications

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Proceedings Article | 19 April 2017 Presentation

Fully integrated optical coherence tomography, ultrasound, and indocyanine green based fluorescence tri-modality system for intravascular imaging (Conference Presentation)

Yan Li, Joseph Jing, Yueqiao Qu, Yusi Miao, Teng Ma, Mingyue Yu, Qifa Zhou, Zhongping Chen

Proceedings Volume 10042, 1004208 (2017) https://doi.org/10.1117/12.2250235

KEYWORDS: Medical laser equipment, Imaging systems, Optical coherence tomography, Luminescence, Intravascular ultrasound, Indocyanine green, Ultrasonography, Integrated optics, Coherence (optics), Tomography

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Proceedings Article | 8 March 2016 Presentation + Paper

Imaging shear wave propagation for elastic measurement using OCT Doppler variance method

Jiang Zhu, Yusi Miao, Yueqiao Qu, Teng Ma, Rui Li, Yongzhao Du, Shenghai Huang, K. Kirk Shung, Qifa Zhou, Zhongping Chen

Proceedings Volume 9697, 96971P (2016) https://doi.org/10.1117/12.2214266

KEYWORDS: Optical coherence tomography, Acoustics, Wave propagation, Coherence (optics), Elastography, Doppler tomography, Tissues, Ultrasonography, Transducers

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Showing 5 of 26 publications

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