Ms. Yulia А. Frolova Profile

Yulia А. Frolova

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Proceedings Article | 27 May 2022 Poster + Paper

Optical modeling of compact Raman biomedical probe for endoscopic applications

Anastasia Shatskaya, Yulia Frolova, Dmitry Artemyev

Proceedings Volume 12144, 121440N (2022) https://doi.org/10.1117/12.2621286

KEYWORDS: Optical design, Raman spectroscopy, Optical filters, Biomedical optics, Spectroscopy, Optical fibers, Fiber optics, Ray tracing, Optical components

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Raman spectroscopy has become widespread in non-destructive, label-free cancer diagnosis during a clinical examination. The development of efficient and flexible devices is allowing for increasing the information content of the recorded Raman spectra and the final diagnostic accuracy in real-time with a high signal-to-noise ratio. In the present work, we developed the design of a miniature fiber optic probe for the implementation of the Raman spectroscopy method for potential endoscopic applications. The optical model of a fiber optic probe was designed using software Zemax OpticStudio. We studied 1) the filtering unit for suppression of laser radiation in the collection channel of the Raman probe made at the entrance to the spectrometer; 2) a set of optical fibers with microstructures at the end as elements that form a probing area of the test sample; 3) optical coupling of a bundle of optical fibers with the entrance slit of the spectrometer. As a result, the influence and prevention of the effect of laser radiation interference between coaxially located filters were shown, which leads to a decrease in the total optical filtering density of the laser wavelength and, accordingly, to a decrease in the signal-to-noise ratio of the system.

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