Multi-sensory fiber-optic probes using nanocrystals as the sensing materials are shown to overcome most limitations
imposed by those using organic dyes as the fluence-rate sensing materials. These nanocrystals are shown to be excitable
by a wide range of wavelengths covering the entire tissue transparent window utilized by various light-enabled
treatment modalities. The optical response of the sensors made from the nanocrystals is shown to be linear without any
sign of photobleaching and sensor crosstalk over a wide range of irradiance and fluence. Fiber probes using the
nanocrystals are promising in offering high spatial resolution in fluence-rate dosimetry for photodynamic therapy and
photothermal treatment.
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