Dr. Timothy N. Ford Profile

Dr. Timothy N. Ford

Principal Systems Engineer at Excelitas Technologies Corp

SPIE Involvement:

Author

Area of Expertise:

Optical Coherence Tomography , Microscopy , Image Processing , Endomicroscopy , Phase Imaging

Websites:

Company Website

Publications (14)

Proceedings Article | 7 March 2022 Presentation

Feasibility and safety of tethered capsule endomicroscopy in studying the natural history of Barrett’s esophagus: a multi-center study

Jing Dong, Catriona Grant, Barry Vuong, Norman Nishioka, Anna Huizi Gao, Matthew Beatty, Grace Baldwin, Aaron Bailargeon, Ara Bablouzian, Patricia Grahmann, Nitasha G. Bhat, Emily Ryan, Amilcar Barrios, Paola Leon Alarcon, Sarah Giddings, Tim Ford, Émilie Beaulieu-Ouellet, Seyed Hamid Hosseiny, Irene Lerman, Wolfgang Trasischker, Rohith Reddy, Kanwarpal Singh, Michalina Gora, Daryl Hyun, Lucille Quénéhervé, Michael Wallace, Wolfsen Herbert, Prateek Sharma, Kenneth Wang, Cadman Leggett, John Poneros, Julian Abrams, Charles Lightdale, Samantha Leeds, Mireille Rosenberg, Guillermo Tearney

Proceedings Volume PC11937, PC119370N (2022) https://doi.org/10.1117/12.2610595

KEYWORDS: Esophagus, Optical coherence tomography, Endoscopy, Endomicroscopy, Safety, Tissues, Imaging systems, Biopsy, Diagnostics, Yield improvement

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Proceedings Article | 5 March 2021 Presentation + Paper

Advantage of low NEP balanced receivers in swept source OCT

Bart Johnson, Tim Ford, Seungbum Woo, Ed Mallon, Mike Crawford, Jason Ensher, Ioan Bucsa, Peter Whitney

Proceedings Volume 11630, 116301M (2021) https://doi.org/10.1117/12.2577854

KEYWORDS: Receivers, Optical coherence tomography, Signal to noise ratio, Signal detection, Interference (communication), Heterodyning, Optical components, Laser resonators, Avalanche photodetectors

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Proceedings Article | 21 February 2020 Presentation + Paper

Achieving the ideal point spread in swept source OCT

Bart Johnson, Tim Ford, Seungbum Woo, Walid Atia, Joey Jabbour, Nate Kemp, Muzammil Arain, Tilman Schmoll, Rick Williams, Peter Whitney

Proceedings Volume 11228, 112281H (2020) https://doi.org/10.1117/12.2543082

KEYWORDS: Deconvolution, Signal processing, Optical coherence tomography, Signal to noise ratio, Clocks, Point spread functions, Vertical cavity surface emitting lasers, Image processing

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Proceedings Article | 7 March 2019 Presentation

Real-time visualization of hidden occlusal and approximal lesions with an OCT dental handpiece (Conference Presentation)

Andrés Zuluaga, Vincent Yang, Joey Jabbour, Timothy Ford, Nate Kemp, Daniel Fried

Proceedings Volume 10857, 108570E (2019) https://doi.org/10.1117/12.2513442

KEYWORDS: Optical coherence tomography, Visualization, Near infrared, Optical imaging, Dental caries, Polarization, Image resolution, Prototyping

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Proceedings Article | 4 March 2019 Presentation

Natural history of Barrett’s esophagus using tethered capsule OCT endomicroscopy and portable OCT imaging system: initial experience (Conference Presentation)

Jing Dong, Barry Vuong, Timothy Ford, Matthew Beatty, Seyed Hamid Hosseiny, Emilie Beaulieu-Ouellet, Rohith Reddy, Kanwarpal Singh, Hany Osman, Catriona Grant, Anna Huizi Gao, Samantha Leeds, Norman Nishioka, John Poneros, Julian Abrams, Charles Lightdale, Prateek Sharma, Michael Wallace, Herbert Wolfsen, Kenneth Wang, Cadman Leggett, Mireille Rosenberg, Guillermo Tearney

Proceedings Volume 10867, 108670T (2019) https://doi.org/10.1117/12.2511523

KEYWORDS: Optical coherence tomography, Esophagus, Imaging systems, Endomicroscopy, Endoscopy, Biopsy, 3D image processing, Clinical trials, Image resolution, Tissues

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While the most common method used to evaluate and survey patients with Barrett’s Esophagus (BE) is endoscopic biopsy, this procedure is invasive, time-consuming, and suffers from sampling errors. Moreover, it requires patient sedation that increases cost and mandates its operation in specialized settings. Our lab has developed a new imaging tool termed tethered capsule endomicroscopy (TCE) that involves swallowing a tethered capsule which utilizes optical coherence tomography (OCT) to obtain three-dimensional microscopic (10µm) images of the entire esophageal wall as it traverses the luminal organ via peristalsis or is retrieved by pulling up tether. As opposed to endoscopy, TCE procedure is non-invasive, doesn’t require patient sedation and mitigates sampling error by evaluating the microscopic structure of the entire esophagus. The merits of TCE make it a suitable device to investigate the microscopic natural history of BE in a longitudinal manner. Here, we present our initial experience of a multicenter (5-site) clinical trial to study the microscopic natural history of BE. The TCE device used for the study is the new generation capsule with the ball lens optical configuration and a distal scan stepper motor, which provides 30µm (lateral) resolution and 40Hz imaging rate. The portable OCT imaging system is a custom in-house built swept source system and provides 7µm (axial) at a 100 kHz A-line rate with a center wavelength of ~1310 nm. To date, we have successfully enrolled 69 subjects at all sites (MGH: 33, Columbia University: 11, Kansas City VA: 10, Mayo Jacksonville: 8, Mayo Rochester: 7) and 59 have swallowed the capsule (85.5%). There have been no reported adverse events associated with TCE procedure. High-quality OCT images were reliably obtained from patients who swallowed the device, and BE tissues were identified by expert readers. Our initial experience with TCE in a multicenter study demonstrates that this technology is easy to use and efficient in multiple clinical settings. Completion of this longitudinal study is likely to provide new insights on the temporal progression of BE that may impact management strategies.

Proceedings Article | 22 February 2019 Presentation + Paper

Tunable 1060nm VCSEL co-packaged with pump and SOA for OCT and LiDAR

Bart Johnson, Walid Atia, Seungbum Woo, Carlos Melendez, Mark Kuznetsov, Tim Ford, Nate Kemp, Joey Jabbour, Ed Mallon, Peter Whitney

Proceedings Volume 10867, 1086706 (2019) https://doi.org/10.1117/12.2510395

KEYWORDS: Vertical cavity surface emitting lasers, LIDAR, Optical coherence tomography, Microelectromechanical systems

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Proceedings Article | 14 March 2018 Presentation

Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy (Conference Presentation)

Chia-Pin Liang, Jing Dong, Timothy Ford, Rohith Reddy, Seyed Hamid Hosseiny Darbrazi, Hamid Farrokhi, Matthew Beatty, Kanwarpal Singh, Barry Vuong, Emilie Beaulieu-Ouellet, Catriona Grant, Sarah Giddings, Mireille Rosenberg, Norman Nishioka, Guillermo Tearney

Proceedings Volume 10470, 104700X (2018) https://doi.org/10.1117/12.2287843

KEYWORDS: Laser marking, Optical coherence tomography, Endomicroscopy, Endoscopy, Laser optics, Coherence (optics), Esophagus, Cancer, Surveillance, Diagnostics

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Proceedings Article | 20 April 2017 Paper

Towards a clinical implementation of uOCT instrument for in vivo imaging of human airways

Hui Min Leung, Dongyao Cui, Timothy Ford, Daryl Hyun, Jing Dong, Biwei Yin, Susan Birket, George Solomon, Linbo Liu, Steven Rowe, Guillermo Tearney

Proceedings Volume 10056, 1005614 (2017) https://doi.org/10.1117/12.2253423

KEYWORDS: Liquids, Pathogens, Human subjects, Imaging systems, Optical coherence tomography, Coherence (optics), Tomography, In vivo imaging, Cystic fibrosis, Image resolution

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Proceedings Article | 19 April 2017 Presentation

Imaging demonstration of a flexible micro-OCT endobronchial probe (Conference Presentation)

Dongyao Cui, Kengyeh Chu, Timothy Ford, Daryl Chulho Hyun, Hui Min Leung, Biwei Yin, Susan Birket, George Solomon, Steven Rowe, Guillermo Tearney

Proceedings Volume 10041, 1004109 (2017) https://doi.org/10.1117/12.2251449

KEYWORDS: Imaging systems, Photomedicine, Optical coherence tomography, Cystic fibrosis, Chronic obstructive pulmonary disease, In vivo imaging, Visualization, Motion models, Performance modeling, Imaging devices

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Proceedings Article | 27 April 2016 Presentation

Flexible micro-OCT endobronchial probe for imaging of mucociliary transport (Conference Presentation)

Dongyao Cui, Kengyeh Chu, Carolin Unglert, Tim Ford, Robert Carruth, Daryl Hyun, Kanwarpal Singh, Susan Birket, George Solomon, Steve Rowe, Guillermo Tearney

Proceedings Volume 9691, 969107 (2016) https://doi.org/10.1117/12.2213057

KEYWORDS: Visualization, Cystic fibrosis, Chronic obstructive pulmonary disease, Pathogens, In vivo imaging, Photomedicine, Imaging systems, Particles, Lung, Liquids

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Mucociliary clearance (MCC) plays a significant role in maintaining the health of human respiratory system by eliminating foreign particles trapped within mucus. Failure of this mechanism in diseases such as cystic fibrosis and chronic obstructive pulmonary disease (COPD) leads to airway blockage and lung infection, causing morbidity and mortality. The volume of airway mucus and the periciliary liquid encapsulating the cilia, in addition to ciliary beat frequency and velocity of mucociliary transport, are vital parameters of airway health. However, the diagnosis of disease pathogenesis and advances of novel therapeutics are hindered by the lack of tools for visualization of ciliary function in vivo. Our laboratory has previously developed a 1-µm resolution optical coherence tomography method, termed Micro-OCT, which is capable of visualizing mucociliary transport and quantitatively capturing epithelial functional metrics. We have also miniaturized Micro-OCT optics in a first-generation rigid 4mm Micro-OCT endoscope utilizing a common-path design and an apodizing prism configuration to produce an annular profile sample beam, and reported the first in vivo visualization of mucociliary transport in swine. We now demonstrate a flexible 2.5 mm Micro-OCT probe that can be inserted through the instrument channel of standard flexible bronchoscopes, allowing bronchoscopic navigation to smaller airways and greatly improving clinical utility. Longitudinal scanning over a field of view of more than 400 µm at a frame rate of 40 Hz was accomplished with a driveshaft transduced by a piezo-electric stack motor. We present characterization and imaging results from the flexible micro-OCT probe and progress towards clinical translation. The ability of the bronchoscope-compatible micro-OCT probe to image mucus clearance and epithelial function will enable studies of cystic fibrosis pathogenesis in small airways, provide diagnosis of mucociliary clearance disorders, and allow individual responses to treatments to be monitored.

SPIE Journal Paper | 3 June 2013 Open Access

Video-rate imaging of microcirculation with single-exposure oblique back-illumination microscopy

Tim Ford, Jerome Mertz

JBO, Vol. 18, Issue 06, 066007, (June 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.6.066007

KEYWORDS: Prisms, Tissues, Capillaries, Absorption, Blood circulation, Distortion, Video, Cameras, Image registration, Microscopy

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SPIE Journal Paper | 13 March 2012 Open Access

Fast optically sectioned fluorescence HiLo endomicroscopy

Timothy Ford, Daryl Lim, Jerome Mertz

JBO, Vol. 17, Issue 02, 021105, (March 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.2.021105

KEYWORDS: Cameras, Luminescence, Endomicroscopy, Video, Image processing, Image resolution, Optical filters, Biomedical optics, Linear filtering, Spatial frequencies

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SPIE Journal Paper | 1 January 2011 Open Access

Optically sectioned in vivo imaging with speckle illumination HiLo microscopy

Daryl Lim, Timothy Ford, Kengyeh Chu, Jerome Metz

JBO, Vol. 16, Issue 1, 016014, (January 2011) https://doi.org/10.1117/12.10.1117/1.3528656

KEYWORDS: Confocal microscopy, Microscopy, Speckle, Microscopes, Luminescence, In vivo imaging, Video, Point spread functions, Speckle pattern, Image processing

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SPIE Journal Paper | 1 May 2009 Open Access

Optically sectioned fluorescence endomicroscopy with hybrid-illumination imaging through a flexible fiber bundle

Silvia Santos, Kengyeh Chu, Daryl Lim, Nenad Bozinovic, Timothy Ford, Claire Hourtoule, Aaron Bartoo, Satish Singh, Jerome Mertz

JBO, Vol. 14, Issue 03, 030502, (May 2009) https://doi.org/10.1117/12.10.1117/1.3130266

KEYWORDS: Image fusion, Microscopy, Luminescence, Endomicroscopy, Linear filtering, Image resolution, Image processing, Spatial frequencies, Video, Modulation

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