The article is devoted to the analysis of skin perfusion oscillation processes with wild-type and synuclein-deficient mice with three knockout (KO) types: αγ-KO, β-KO, and αβγ-KO. The role of synucleins in tissues that exclude the central nervous system remains sparsely studied. Laser Doppler flowmetry was used to investigate the potential involvement of synucleins in murine microcirculation functioning This method is widely used to analyze microcirculatory disturbances in a variety of pathologies and has proven to be sensitive to the manifestation of abnormalities of normal function. The study revealed that deficiency of β-synuclein affects oscillation processes more than αγ-synuclein deficiency.
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