Functional near-infrared spectroscopy (fNIRS) and diffuse correlation spectroscopy (DCS) have shown promise as non-invasive optical methods for cerebral functional imaging. Both approaches currently have limits to sensitivity in adults. Sensitivity can be improved using temporal discrimination, where the laser excitation is of short (~400ps) duration and the detector rejects early photons that have not penetrated into the brain while maintain high sensitivity to those that have. We report here further demonstration of a high-speed Read-Out Integrated Circuit (ROIC) that integrates with a 32x32 Single-Photon Avalanche photo-Detector (SPAD) array that can be either silicon (Si, for visible to infra-red) in indium-phosphide (InP, to allow operation at 1064nm). Data is exfiltrated serially directly to an FPGA where it can be processed in real time. This presentation will include results of recent detector performance tests and phantom demonstrations using this powerful new tool.
Functional near-infrared spectroscopy (fNIRS) and diffuse correlation spectroscopy (DCS) have shown promise as non-invasive optical methods for cerebral functional imaging. DCS approaches currently have limited sensitivity in adults. fNIRS sensitivity is also limited, particularly in high-detector-density applications. Sensitivity can be improved using temporal discrimination (TD), where the laser excitation is of short (~400ps) duration and the detector rejects early photons that have not penetrated into the brain while maintain high sensitivity to those that have. We report here on the development of a novel 32x32 Single-Photon Avalanche photo-Detector (SPAD) array and Read-Out Integrated Circuit (ROIC) that can operate in either the visible or NIR enabling high-channel-count TD-fNIRS or TD-DCS systems.
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