Ms. Kshama Doshi Profile

Kshama Doshi

at Boston Univ

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 4 March 2019 Presentation

Towards in vivo preclinical monitoring of multiscale vascular structure-function relationships in resistant breast cancers with an integrated diffuse and nonlinear imaging system (Conference Presentation)

Kavon Karrobi, Anahita Pilvar, Anup Tank, Kshama Doshi, David Waxman, Darren Roblyer

Proceedings Volume 10871, 108710E (2019) https://doi.org/10.1117/12.2508872

KEYWORDS: In vivo imaging, Tumors, Breast cancer, Imaging systems, Brain-machine interfaces, Resistance, Therapeutics, Tissues, Preclinical imaging, Nonlinear optics

Read Abstract +

Alterations in tumor microvascular architecture are associated with resistance to several breast cancer therapies, and may be important markers for in vivo detection of resistance. Our goal is to map how micro-scale alterations in tumor vasculature manifest at the tissue level. To this end, we developed a multiscale preclinical imaging technique called Diffuse and Nonlinear Imaging (DNI) that integrates Spatial Frequency Domain Imaging (SFDI) for tissue-level mapping of tumor optical properties and hemodynamics, with Multiphoton Microscopy (MPM) to image tumor microvascular architecture with cellular resolution. Importantly, SFDI measures the same parameters as clinical Diffuse Optical Spectroscopy, providing a pathway to the clinic for microvascular imaging biomarkers. We demonstrated that the dual modality system can be spatially co-registered with high accuracy and precision (≤ 50 µm), and can be matched in optical sampling depth based on wavelength and spatial frequency selection. We also conducted an in vivo DNI study of untreated murine mammary tumors (Py230) in female C57BL/6 mice, and found strong multiscale relationships between tumor oxygen saturation and micro-vessel diameter, as well as deoxyhemoglobin concentrations and micro-vessel length (|Pearson’s ρ| > 0.5, p < 0.05). We carried out in vivo DNI monitoring in two mammary tumor xenograft models grown in BALB/c athymic nude female mice; one model was responsive to Trastuzumab (Herceptin®) (BT474) and the other was resistant (HR6). This presentation will report on characterizing the vascular structure-function relationships with DNI across length scales within each model, and differences in the multiscale vascular relationships between the models.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years