Optical coherence elastography (OCE) is an imaging technique capable of mapping mechanical properties (such as elasticity) in 3-D and is emerging as a valuable tool in the study and potential intraoperative diagnosis of breast cancer due to mechanical contrast between healthy and malignant tissue. While the correlation between elevated elasticity in OCE and breast cancers has been well established, these studies have primarily focused on binary classifications of tissue as either malignant or benign, ignoring much of the heterogeneity present in breast tissue. In this work, we present a detailed assessment of the microstructures present in human breast tissue images acquired with OCE, identifying regions of interest that corresponded to invasive carcinomas, in situ carcinomas and benign tissue types. We also describe the unique morphological patterns present in each tissue type and provide a framework for the interpretation of breast cancer images acquired with OCE.
In this work, we present the development of a compact, wireless imaging probe using a cost effective camera based optical elastography technique, stereoscopic optical palpation, towards intraoperative tumour assessment for breast cancer surgery. We demonstrate the working principle of this probe and test its capability of tumour margin assessment on freshly excised tissues. With further development, this probe holds the potential to be used as a real time cancer imaging tool that can help surgeons more effectively remove cancer during the operation, reducing the need for follow-up surgery. The probe has the potential to be used in rural and remote areas.
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