Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia which is considered to be a primary cause of treatment resistance observed in these tumors. Desmoplasia also plays a major role in mediating an immunosuppressive microenvironment and restricting immune cell infiltration in PDAC. In this study, using a syngeneic orthotopic immunocompetent KPC PDAC model, we demonstrate that PDT using Visudyne® can alter the tumor microenvironment, enhances immune cell infiltration, significantly reducing tumor growth and increasing survival in combination with anti-PD1.
In this study, we study the influence of dye to antibody ratio on the imaging and therapeutic performance of an EGFR-targeted dual function conjugate. We further demonstrate the efficacy of the conjugate in identifying tumor depth to guide surgical resections and the ability to eliminate residual microscopic disease through photoimmunotherapy, in a single intra-operative setting.
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