Ms. Elena S. Sedova Profile

Elena S. Sedova

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Proceedings Article | 5 March 2021 Presentation + Paper

Comparing of efficiency of photobiomodulation of red and infrared spectrum for the correction of radiation-induced oral mucositis

Elena Sedova, Vladimir Yusupov, Nataliya Vorobieva, Nadezhda Kanisheva, Anna V. Maslennikova

Proceedings Volume 11628, 116280D (2021) https://doi.org/10.1117/12.2578077

KEYWORDS: Infrared radiation, Light emitting diodes, Cancer, Toxicity, Tissues, Oncology

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The aim of this study was to compare the effectiveness of low-intensity LED radiation of the red and infrared spectra for the correction of mucositis in patients receiving radiation and chemoradiation therapy for oral and pharyngeal cancer at an energy density of less than 1 J/cm². The study included 106 patients who received radiation and chemoradiation therapy for oral cavity and pharyngeal cancer, who were randomly divided into three groups. In the first (37 patients) correction of mucositis was carried out in accordance with the clinic's standards, in the second (36 patients) and the third (33 patients), patients additionally received exposure to the oral cavity with low-intensity LED radiation at a wavelength of 635 nm at a dose of 0,3 J/cm²(prophylactic regimen) and 0.45 J/cm² (treatment regimen). When exposed to a wavelength of 780 nm, the dose was 0.6 J/cm² with a prophylactic regime and 0.8 J/cm² with a therapeutic regimen, respectively. Exposure to low-level LED irradiation at a wavelength of 635 nm significantly reduced the frequency and severity of radiation mucositis, increased the time until the onset of its first symptoms, reduced the duration of severe mucositis (grade 3) and reduced the patients' need for painkillers, including narcotic analgesics compared with the group receiving standard prophylaxis and correction of mucositis. Photobiomodulation at a wavelength of 780 nm, compared with the standard correction group, significantly increased the time to the onset of the first symptoms of mucositis and decreased the severity of pain.

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