Mr. Christopher M. Polleys Profile

Christopher M. Polleys

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Author

Publications (10)

SPIE Journal Paper | 22 December 2023 Open Access

Restoration of metabolic functional metrics from label-free, two-photon human tissue images using multiscale deep-learning-based denoising algorithms

Nilay Vora, Christopher M. Polleys, Filippos Sakellariou, Georgios Georgalis, Hong-Thao Thieu, Elizabeth Genega, Narges Jahanseir, Abani Patra, Eric Miller, Irene Georgakoudi

JBO, Vol. 28, Issue 12, 126006, (December 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.12.126006

KEYWORDS: Education and training, Data modeling, Denoising, Tissues, Image quality, Wavelets, Nicotinamide adenine dinucleotide, Mitochondria, Image quality standards, Biopsy

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Proceedings Article | 17 March 2023 Presentation

Label free multi-photon metabolic imaging: from mitochondria to humans

Irene Georgakoudi, Christopher Polleys, Yang Zhang, Volha Liaudanskaya, Adriana Sanchez, Einstein Gnanatheepam, Maria Savvidou, David Kaplan, Hong-Thao Thieu, Elizabeth Genega, Thomas Schenlldorfer, Jessica Shiu, Anand Ganesan, Mihaela Balu

Proceedings Volume PC12363, PC123630G (2023) https://doi.org/10.1117/12.2658901

KEYWORDS: Tissues, Traumatic brain injury, Statistical modeling, Nondestructive evaluation, Luminescence, In vivo imaging

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Proceedings Article | 16 March 2023 Presentation + Paper

Denoising of depth-resolved, label-free, two-photon images using deep-learning-based algorithms

Nilay Vora, Christopher Polleys, Filippos Sakellariou, Hong-Thao Thieu, Elizabeth Genega, Irene Georgakoudi

Proceedings Volume 12391, 1239107 (2023) https://doi.org/10.1117/12.2650856

KEYWORDS: Denoising, Tissues, Image quality, In vivo imaging, Image restoration, Tissue optics, Image quality standards, Machine learning, Deep learning, Metabolism, Two photon excitation microscopy, Image analysis

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Proceedings Article | 16 March 2023 Presentation

Evaluation of the preservation of tissue metabolic function in fresh and fixed epithelium using label-free two-photon fluorescence microscopy (Conference Presentation)

Adriana Sánchez-Hernández, Christopher Polleys, Irene Georgakoudi

Proceedings Volume PC12391, PC1239108 (2023) https://doi.org/10.1117/12.2650776

KEYWORDS: Tissues, Two photon excitation microscopy, Tissue optics, Luminescence, Biological research, Mode conditioning cables, Image acquisition, Fluorescence lifetime imaging, Data processing, Data analysis

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Proceedings Article | 15 March 2023 Presentation + Paper

Two-photon imaging of endogenous biomolecules in freshly excised human cervical tissue biopsies captures pre-cancer induced changes in tissue metabolism and morphology

Christopher Polleys, Hong-Thao Thieu, Elizabeth Genega, Narges Jahanseir, Irene Georgakoudi

Proceedings Volume 12363, 1236302 (2023) https://doi.org/10.1117/12.2650926

KEYWORDS: Tissues, Second harmonic generation, Collagen, Fluorescence lifetime imaging, Biopsy, Flavoproteins, Mitochondria, Autofluorescence, Two photon imaging, Cervix, Nicotinamide adenine dinucleotide, Metabolism

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Proceedings Article | 27 May 2022 Poster + Paper

Machine learning based classification system using depth-dependent variation encoding for classifying cervical two-photon excited fluorescence image stacks

Foram Sanghavi, Karen Panetta, Sos Agaian, Christopher Polleys, Hong-Thao Thieu, Elizabeth Genega, Irene Georgakoudi

Proceedings Volume 12100, 121000T (2022) https://doi.org/10.1117/12.2623305

KEYWORDS: Image enhancement, Denoising, Tissues, Computer programming, Feature extraction, Luminescence, Image classification, Machine learning, Classification systems, Two photon excitation microscopy, Cervical cancer

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Proceedings Article | 5 March 2021 Open Access

In-vivo optical microscopy and single cell transcriptomics approaches provide insights into therapeutic response of vitiligo

Griffin Lentsch, Jessica Shiu, Jessica Flesher, Pezhman Mobasher, Christopher Polleys, Craig Mizzoni, Karsten König, Suoqin Jin, Lihua Zhang, Bruce Tromberg, Qing Nie, Irene Georgakoudi, Anand Ganesan, Mihaela Balu

Proceedings Volume 11618, 116180P (2021) https://doi.org/10.1117/12.2582167

KEYWORDS: Skin, In vivo imaging, Optical microscopy, Resistance, Reflectivity, Quantitative analysis, Multiphoton microscopy, Confocal microscopy

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Proceedings Article | 5 March 2021 Open Access

Non-invasive, label-free, two-photon detection of epithelial metabolic precursors to repigmentation in vitiligo micrografts

Christopher Polleys, Griffin Lentsch, Bruce Tromberg, Anand Ganesan, Francisca Rius-Diaz, Mihaela Balu, Irene Georgakoudi

Proceedings Volume 11655, 116550F (2021) https://doi.org/10.1117/12.2578676

KEYWORDS: Skin, Luminescence, Tissues, Phototherapy, Multiphoton processes, Multiphoton microscopy

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Proceedings Article | 5 March 2021 Presentation

Deep-learning-based image restoration of depth-resolved, label-free, two-photon images for the quantitative morphological and functional characterization of human cervical tissues

Christopher Polleys, Panagiotis Lymperopoulos, Hong-Thao Thieu, Elizabeth Genega, Liping Liu, Irene Georgakoudi

Proceedings Volume 11647, 116470Z (2021) https://doi.org/10.1117/12.2578650

KEYWORDS: Image restoration, Tissues, Signal to noise ratio, In vivo imaging, Biopsy, Two photon imaging, Microscopy, Luminescence, Imaging systems, Image quality

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Proceedings Article | 1 April 2020 Presentation

Multiparametric, label-free two-photon imaging of metabolic function (Conference Presentation)

Irene Georgakoudi, Dimitra Pouli, Zhiyi Liu, Yang Zhang, Christopher Polleys

Proceedings Volume 11351, 113510A (2020) https://doi.org/10.1117/12.2566323

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Showing 5 of 10 publications

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