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In this work, we present an innovative labeled biosensing technique exploiting magnetic nano-beads for enhancement of sensitivity over integrated optic microrings. A sandwich binding is exploited to bring the magnetic labels close to the surface of the optical waveguide and interact with the optical evanescent field.
The proximity and the quantity of the magnetic nano-beads are seen as a shift in the resonance of the microring. Detection of antibodies permits to reach a high level of sensitivity, down to 8 pM with a high confidence level. The sizes of the nano-beads are 50 to 250 nm. Furthermore, time-varying magnetic fields permit to manipulate the beads and even induce specific signals on the detected light to easy the processing and provide a reliable identification of the presence of the desired analyte. Multiple analytes detection is also possible.
The Course all in English aims to provide high-level theoretical and technical competence in the fields of optics, photonics and optoelectronics. Students on the programme have a unique opportunity to study within a truly multicultural environment, by spending time at each participating institution in turn: Marseille; Berlin and Milan. The organization and the pedagogy will be presented.
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