Miniaturized CARS endomicroscopic probe with a large field of view using a MEMS mirror scanner: concept and design considerations

Chenting Lai; Aida Amantayeva; Karl Reichwald; Sandra Gerlach-Anhut; Tobias Meyer-Zedler; Adrian Lorenz; Jörg Bierlich; Tobias Habisreuther; Bernhard Messerschmidt

doi:10.1117/12.3003833

12 March 2024 Miniaturized CARS endomicroscopic probe with a large field of view using a MEMS mirror scanner: concept and design considerations

Chenting Lai, Aida Amantayeva, Karl Reichwald, Sandra Gerlach-Anhut, Tobias Meyer-Zedler, Adrian Lorenz, Jörg Bierlich, Tobias Habisreuther, Bernhard Messerschmidt

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Proceedings Volume 12820, Endoscopic Microscopy XIX; 1282003 (2024) https://doi.org/10.1117/12.3003833
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We present here the concept of a MEMS-mirror based nonlinear endomicroscopic probe for coherent anti-Stokes Raman scattering (CARS), two-photon excitation fluorescence (TPEF), and second harmonic generation (SHG). The rigid probe head is 5 mm in diameter and 4 cm in length, offering a large field of view (FOV) with a high numerical aperture (NA). It incorporates a double-core fiber delivering two excitation wavelengths of CARS in isolated cores, with a large cladding area to increase the collection efficiency of the nonlinear signal from the tissue. A diffractive grating element is included in the probe to compensate for the spatial offset of two emission cores.

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Chenting Lai, Aida Amantayeva, Karl Reichwald, Sandra Gerlach-Anhut, Tobias Meyer-Zedler, Adrian Lorenz, Jörg Bierlich, Tobias Habisreuther, and Bernhard Messerschmidt "Miniaturized CARS endomicroscopic probe with a large field of view using a MEMS mirror scanner: concept and design considerations", Proc. SPIE 12820, Endoscopic Microscopy XIX, 1282003 (12 March 2024); https://doi.org/10.1117/12.3003833

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