Progress on the development of FF-SS-OCT system for functional retinal imaging

Ratheesh K. Meleppat; Denise Valente; Ewelina Pijewska; Soohyun Lee; Ravi S. Jonnal; Nathan Doble; Robert J. Zawadzki

doi:10.1117/12.2650676

14 March 2023 Progress on the development of FF-SS-OCT system for functional retinal imaging

Ratheesh K. Meleppat, Denise Valente, Ewelina Pijewska, Soohyun Lee, Ravi S. Jonnal, Nathan Doble, Robert J. Zawadzki

Proceedings Volume 12360, Ophthalmic Technologies XXXIII; 123600N (2023) https://doi.org/10.1117/12.2650676
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Light-evoked functional retinal imaging is of great interest in clinical and experimental ophthalmology because the alterations in retinal function hold the promise of being potentially more sensitive for disease diagnosis than purely morphology-based assays. Recent progress in Optoretinography (ORG), a technique employing OCT to extract light-evoked functional response of retinal tissue, promises to provide the needed sensitivity to probe early alterations in retinal function. The most promising implementations of the ORG probing of photoreceptor function in clinical settings are using parallel OCT detection schemes such as Line Field and Full Field designs. Herein, we present the instrumentation scheme of a Full-Field-Swept-Source OCT (FF-SS-OCT) system incorporating a high-precision light stimulation channel for facilitating phase-based functional retinal imaging in mice. The assessment of the OCT signal phase errors and their correction using short-time Fourier transform (STFT) is detailed. The performance of the system is investigated using a model eye.

Citation Download Citation

Ratheesh K. Meleppat, Denise Valente, Ewelina Pijewska, Soohyun Lee, Ravi S. Jonnal, Nathan Doble, and Robert J. Zawadzki "Progress on the development of FF-SS-OCT system for functional retinal imaging", Proc. SPIE 12360, Ophthalmic Technologies XXXIII, 123600N (14 March 2023); https://doi.org/10.1117/12.2650676

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