Multiple reactions monitoring for cocaine and ethylbenzoylecgonine to increase the signal/noise ratio in mass spectrometry analysis

Ruxandra Populeanu; Radu Alexandru Macovei; Marian Vlădescu; Gabriela Anghelescu; Genica Caragea; Alexandra Andrada Bojescu; Mihai Ionică

doi:10.1117/12.2322569

31 December 2018 Multiple reactions monitoring for cocaine and ethylbenzoylecgonine to increase the signal/noise ratio in mass spectrometry analysis

Ruxandra Populeanu, Radu Alexandru Macovei, Marian Vlădescu, Gabriela Anghelescu, Genica Caragea, Alexandra Andrada Bojescu, Mihai Ionică

Author Affiliations +

Proceedings Volume 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX; 1097738 (2018) https://doi.org/10.1117/12.2322569
Event: Advanced Topics in Optoelectronics, Microelectronics and Nanotechnologies IX, 2018, Constanta, Romania

Abstract

Drug abuse consists of the use by a subject without a medical recommendation, in quantities or with nonrecommended methods. Substance abuse also refers to their use in order to increase intellectual or physical performance, against the rules established by society. Substance abuse involves the chronic use of non-medical chemicals for hedonistic or entheogenic purposes [1]. Drugs such as alcohol, antidepressants, amphetamine, barbiturates, benzodiazepines, cannabinoids, glue, cocaine, hallucinogens, metacular, narcotics, opiates, sedatives, stimulants and some organic solvents can be named [2]. Substance abuse can cause criminal or antisocial behavior, may generate long-term changes in personality [3].

Cocaine has major toxic effects on the body. Treatment of cocaine poisoning is complex. The main sales are those that can lead to patient death. For the proper treatment of any inoculation, it is necessary to identify the xenobiotic that generated it. The presence of metabolites, in the case of cocaine - ethylbenzoylcogene (EBE), provides information on the time of administration of the xenobiotic.

Gas chromatography or liquid chromatography coupled with mass spectrometry is an optoelectronic method that can identify the presence of cocaine and / or EBE from biological samples. In order to increase the sensitivity of the method, a special mass metrology technique - MS/MS can be used [4, 5].

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Ruxandra Populeanu, Radu Alexandru Macovei, Marian Vlădescu, Gabriela Anghelescu, Genica Caragea, Alexandra Andrada Bojescu, and Mihai Ionică "Multiple reactions monitoring for cocaine and ethylbenzoylecgonine to increase the signal/noise ratio in mass spectrometry analysis", Proc. SPIE 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX, 1097738 (31 December 2018); https://doi.org/10.1117/12.2322569

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KEYWORDS

Ions

Mass spectrometry

Chromatography

Optoelectronics

Signal to noise ratio

Sodium

Information technology

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