Dr. Eli Pewzner Profile

Dr. Eli Pewzner

CEO and R&D Manager at Prizmatix Ltd

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Publications (11)

SPIE Journal Paper | 1 June 2011 Open Access

Mitochondrial function and tissue vitality: bench-to-bedside real-time optical monitoring system

Avraham Mayevsky, Eliyahu Pewzner, Assaf Deutsch, Raphael Walden, Eitan Heldenberg, Jacob Lavee, Salis Tager, Erez Kachel, Ehud Raanani, Sergey Preisman, Violete Glauber, Eran Segal

JBO, Vol. 16, Issue 06, 067004, (June 2011) https://doi.org/10.1117/12.10.1117/1.3585674

KEYWORDS: Tissues, Tissue optics, Oxygen, Blood circulation, Blood, Surgery, In vivo imaging, Luminescence, Brain, Reflectivity

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Proceedings Article | 21 February 2009 Paper

Evaluation of the CritiView in pig model of abdominal aortic occlusion and graded hemorrhage

A. Mayevsky, S. Preisman, P. Willenz, D. Castel, A. Perel, D. Givony, N. Dekel, L. Oren, E. Pewzner

Proceedings Volume 7173, 71730L (2009) https://doi.org/10.1117/12.808690

KEYWORDS: Blood, Tissues, Oxygen, Blood circulation, Tissue optics, Bladder, Hemodynamics, Reflectivity, Animal model studies, Intestine

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Proceedings Article | 8 February 2008 Paper

Mitochondrial dysfunction: bench-to-bedside optical monitoring of tissue vitality

Avraham Mayevsky, Nava Dekel, Levi Oren, Assaf Deutsch, Eliyahu Pewzner

Proceedings Volume 6853, 68531B (2008) https://doi.org/10.1117/12.761118

KEYWORDS: Tissue optics, Tissues, Luminescence, Oxygen, Surgery, Blood circulation, Ischemia, Blood, Digital signal processing, In vivo imaging

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In normal cell the mitochondria are the major source of energy for cellular functions. They serve as biosensors for oxidative stress and involved also in termination of cell function by apoptosis. The involvement of mitochondria in pathological states such as neurodegenerative diseases, sepsis, stroke and cancer are well documented. The involvement of mitochondrial respiration and function in cancer development, proliferation and possible therapy were initiated 75 years ago by Otto Warburg. Monitoring of NADH fluorescence in vivo as an intracellular oxygen indicator was established in the 1950-1970 by Britton Chance and collaborators. In the last 20 years we developed and used a multiparametric monitoring system enabling real time assessment of mitochondria NADH, microcirculatory blood flow and volume as well as HbO₂ oxygenation. In order to use this technology in clinical practice the commercial developed device-the "CritiView" was tested in animal models as well as in patients hospitalized in the critical care departments. In patients we tested the viability of the urethral wall (a less-vital tissue) by a 3 way Foley urinary catheter that contains the optical probe. The catheter was introduced to patients underwent open heart by-pass surgery or abdominal aorta aneurysm (AAA) operations. The monitoring started immediately after the insertion of the catheter to the patient and was stopped when the patient was discharged from the operation room. The results show that monitoring of the vitality of the Urethral wall provides information in correlation to the surgical procedure performed. In the AAA patients the occlusion of the aorta led to severe ischemia developed in the urethral wall and recovery of signals were recorded after the reopening of the aorta. In patients under went heart bypass surgery the urethra vitality was decreased dramatically during the operation and recovery was noted in most patients after the discharge of the patient from the operation room.

Proceedings Article | 6 February 2007 Paper

Optical assessment of intravascular and intracellular parameters related to tissue viability

Avraham Mayevsky, Efrat Sherman, Meir Cohen-Kashi, Nava Dekel, Eliyahu Pewzner

Proceedings Volume 6430, 64300Z (2007) https://doi.org/10.1117/12.699778

KEYWORDS: Tissue optics, Blood, Tissues, Reflectivity, Brain, Ischemia, Oximeters, Laser tissue interaction, Blood circulation, Oxygen

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Proceedings Article | 15 February 2006 Paper

The CritiView: a new fiber optic based optical device for the assessment of tissue vitality

Avraham Mayevsky, Yoram Blum, Nava Dekel, Assaf Deutsch, Rafael Halfon, Shlomi Kremer, Eliyahu Pewzner, Efrat Sherman, Ofer Barnea

Proceedings Volume 6083, 60830Z (2006) https://doi.org/10.1117/12.675745

KEYWORDS: Tissues, Tissue optics, Light sources, Brain, Reflectivity, Fiber optics, Ischemia, Luminescence, Blood, Laser tissue interaction

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Proceedings Article | 1 April 2005 Paper

A new biomedical device for in vivo multiparametric evaluation of tissue vitality in critical care medicine

Avraham Mayevsky, Assaf Deutsch, Nava Dekel, Eliyahu Pevzner, Alex Jaronkin

Proceedings Volume 5692, (2005) https://doi.org/10.1117/12.587584

KEYWORDS: Tissues, Blood, Brain, Luminescence, Reflectivity, Tissue optics, In vivo imaging, Blood circulation, Oxygen, Ischemia

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SPIE Journal Paper | 1 September 2004 Open Access

Tissue spectroscope: a novel in vivo approach to real time monitoring of tissue vitality

Avraham Mayevsky, Tamar Manor, Eliyahu Pevzner, Assaf Deutsch, Revital Etziony, Nava Dekel, Alex Jaronkin

JBO, Vol. 9, Issue 05, (September 2004) https://doi.org/10.1117/12.10.1117/1.1780543

KEYWORDS: Tissues, In vivo imaging, Tissue optics, Brain, Oxygen, Luminescence, Blood, Blood circulation, Doppler effect, Optical fibers

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Proceedings Article | 10 June 2004 Paper

Real-time evaluation of tissue vitality by monitoring of microcirculatory blood flow, HbO2, and mitochondrial NADH redox state

Assaf Deutsch, Eliyahu Pevzner, Alex Jaronkin, Avraham Mayevsky

Proceedings Volume 5317, (2004) https://doi.org/10.1117/12.528601

KEYWORDS: Tissues, Tissue optics, Reflectivity, Light emitting diodes, Light sources, Blood circulation, Oxygen, Ischemia, Luminescence, Blood

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Proceedings Article | 22 July 2003 Paper

Real-time multiparametric spectroscopy as a practical tool for evaluation of tissue vitality in vivo

Eliyahu Pevzner, Assaf Deutsch, Tamar Manor, Nava Dekel, Revital Etziony, Igor Derzy, Nisim Razon, Avraham Mayevsky

Proceedings Volume 4958, (2003) https://doi.org/10.1117/12.476121

KEYWORDS: Tissue optics, Semiconductor lasers, Tissues, Brain, Light sources, Sensors, Fiber optics, Ultraviolet radiation, Doppler effect, Luminescence

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Proceedings Article | 26 March 2002 Paper

Real-time optical monitoring of tissue vitality in vivo

Avraham Mayevsky, Tamar Manor, Eliyahu Pevzner, Assaf Deutsch, Revital Etziony, Nava Dekel

Proceedings Volume 4616, (2002) https://doi.org/10.1117/12.463821

KEYWORDS: Tissue optics, Tissues, Brain, In vivo imaging, Blood circulation, Light sources, Optical fibers, Luminescence, In vitro testing, Spectroscopes

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Proceedings Article | 1 June 1991 Paper

Spectroscopic properties of the potentiometric probe merocyanine-540 in solutions and liposomes

Benjamin Ehrenberg, Eliyahu Pevzner

Proceedings Volume 1432, (1991) https://doi.org/10.1117/12.44214

KEYWORDS: Raman spectroscopy, Spectroscopy, Absorption, Luminescence, Ions, Diffusion, Dielectrics, Instrument modeling, Absorbance, Mass attenuation coefficient

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Showing 5 of 11 publications

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