Modulation frequency improves imaging hemoglobin fluctuation in frequency domain high-density diffuse optical tomography

Weihao Fan; Hamid Dehghani; Adam T. Eggebrecht

doi:10.1117/12.2610185

4 March 2022 Modulation frequency improves imaging hemoglobin fluctuation in frequency domain high-density diffuse optical tomography

Weihao Fan, Hamid Dehghani, Adam T. Eggebrecht

Author Affiliations +

Proceedings Volume 11945, Clinical and Translational Neurophotonics 2022; 1194506 (2022) https://doi.org/10.1117/12.2610185
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We investigated the effects of modulation frequency on image quality with FD-HD-DOT through simulations with a realistic noise model of functional activations in human head models, arising from 11 source modulation frequencies between CW and 1,000 MHz. Functional reconstructions were simulated in five fMRI-based head models covered by 158 light sources and 166 detectors and a realistic noise model was considered. We quantitatively evaluated image quality by assessing the localization error (LE), success rate, full width at half maximum (FWHM), and full volume at half maximum (FVHM) of recoveries. The results show that the optimized frequencies are about 300~500 MHz for image quality and 300 MHz for reliable field of view when accounting for realistic noise.

Conference Presentation

Citation Download Citation

Weihao Fan, Hamid Dehghani, and Adam T. Eggebrecht "Modulation frequency improves imaging hemoglobin fluctuation in frequency domain high-density diffuse optical tomography", Proc. SPIE 11945, Clinical and Translational Neurophotonics 2022, 1194506 (4 March 2022); https://doi.org/10.1117/12.2610185

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