Whole-head functional brain imaging of neonates at cot-side using time-resolved diffuse optical tomography

Laura A. Dempsey; Robert J. Cooper; Samuel Powell; Andrea Edwards; Chuen-Wai Lee; Sabrina Brigadoi; Nick Everdell; Simon Arridge; Adam P. Gibson; Topun Austin; Jeremy C. Hebden

doi:10.1117/12.2190420

16 July 2015 Whole-head functional brain imaging of neonates at cot-side using time-resolved diffuse optical tomography

Laura A. Dempsey, Robert J. Cooper, Samuel Powell, Andrea Edwards, Chuen-Wai Lee, Sabrina Brigadoi, Nick Everdell, Simon Arridge, Adam P. Gibson, Topun Austin, Jeremy C. Hebden

Author Affiliations +

Proceedings Volume 9538, Diffuse Optical Imaging V; 953818 (2015) https://doi.org/10.1117/12.2190420
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

We present a method for acquiring whole-head images of changes in blood volume and oxygenation from the infant brain at cot-side using time-resolved diffuse optical tomography (TR-DOT). At UCL, we have built a portable TR-DOT device, known as MONSTIR II, which is capable of obtaining a whole-head (1024 channels) image sequence in 75 seconds. Datatypes extracted from the temporal point spread functions acquired by the system allow us to determine changes in absorption and reduced scattering coefficients within the interrogated tissue. This information can then be used to define clinically relevant measures, such as oxygen saturation, as well as to reconstruct images of relative changes in tissue chromophore concentration, notably those of oxy- and deoxyhaemoglobin. Additionally, the effective temporal resolution of our system is improved with spatio-temporal regularisation implemented through a Kalman filtering approach, allowing us to image transient haemodynamic changes. By using this filtering technique with intensity and mean time-of-flight datatypes, we have reconstructed images of changes in absorption and reduced scattering coefficients in a dynamic 2D phantom. These results demonstrate that MONSTIR II is capable of resolving slow changes in tissue optical properties within volumes that are comparable to the preterm head. Following this verification study, we are progressing to imaging a 3D dynamic phantom as well as the neonatal brain at cot-side. Our current study involves scanning healthy babies to demonstrate the quality of recordings we are able to achieve in this challenging patient population, with the eventual goal of imaging functional activation and seizures.

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Laura A. Dempsey, Robert J. Cooper, Samuel Powell, Andrea Edwards, Chuen-Wai Lee, Sabrina Brigadoi, Nick Everdell, Simon Arridge, Adam P. Gibson, Topun Austin, and Jeremy C. Hebden "Whole-head functional brain imaging of neonates at cot-side using time-resolved diffuse optical tomography ", Proc. SPIE 9538, Diffuse Optical Imaging V, 953818 (16 July 2015); https://doi.org/10.1117/12.2190420

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