Cerebral perfusion and metabolic neuromonitoring during cardiopulmonary bypass

Ajay Rajaram; Marianne Suwalski; Daniel Milej; Lawrence C. M. Yip; Linrui Ray Guo; Michael W. A. Chu; Jason Chui; Mamadou Diop; John Murkin; Keith St. Lawrence

doi:10.1117/12.2578986

5 March 2021 Cerebral perfusion and metabolic neuromonitoring during cardiopulmonary bypass

Ajay Rajaram, Marianne Suwalski, Daniel Milej, Lawrence C. M. Yip, Linrui Ray Guo, Michael W. A. Chu, Jason Chui, Mamadou Diop, John Murkin, Keith St. Lawrence

Author Affiliations +

Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 116391G (2021) https://doi.org/10.1117/12.2578986
Event: SPIE BiOS, 2021, Online Only

Abstract

During surgery with cardiopulmonary bypass (CPB), maintaining adequate cerebral blood flow (CBF) is paramount to prevent adverse neurological outcome; tissue damage can occur if CBF reduction is sufficient to impair energy metabolism. Ten adult patients undergoing cardiothoracic surgery with CPB received perfusion and metabolic neuromonitoring using a novel optical system combining diffuse correlation spectroscopy and broadband near-infrared spectroscopy. CPB onset resulted in large increases in CBF and significant drops in mean arterial pressure and metabolism. No changes were observed transitioning off CPB. Real-time assessment of cerebral perfusion and metabolism could alert clinicians to relevant hemodynamic events before brain injury occurs.

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Ajay Rajaram, Marianne Suwalski, Daniel Milej, Lawrence C. M. Yip, Linrui Ray Guo, Michael W. A. Chu, Jason Chui, Mamadou Diop, John Murkin, and Keith St. Lawrence "Cerebral perfusion and metabolic neuromonitoring during cardiopulmonary bypass", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 116391G (5 March 2021); https://doi.org/10.1117/12.2578986

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