Effects of mild hypothermic cardiopulmonary bypass on cerebral hemodynamics: comparison of diffuse optical and cerebral microdialysis metrics in neonatal swine

Emilie J. Benson; Lindsay E. Volk; Tiffany S. Ko; Jonathan P. Starr; Samy Belbegra; Wesley B. Baker; Jonah A. Padawer-Curry; Kristen N. Andersen; Alexander L. Schmidt; Thomas Hallowell; Yuxi Lin; Anna L. Roberts; Nile Delso; William P. Landis; Daniel J. Licht; Arjun G. Yodh; Todd J. Kilbaugh

doi:10.1117/12.2579337

5 March 2021 Effects of mild hypothermic cardiopulmonary bypass on cerebral hemodynamics: comparison of diffuse optical and cerebral microdialysis metrics in neonatal swine

Emilie J. Benson, Lindsay E. Volk, Tiffany S. Ko, Jonathan P. Starr, Samy Belbegra, Wesley B. Baker, Jonah A. Padawer-Curry, Kristen N. Andersen, Alexander L. Schmidt, Thomas Hallowell, Yuxi Lin, Anna L. Roberts, Nile Delso, William P. Landis, Daniel J. Licht, Arjun G. Yodh, Todd J. Kilbaugh

Author Affiliations +

Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 116391F (2021) https://doi.org/10.1117/12.2579337
Event: SPIE BiOS, 2021, Online Only

Abstract

Mild hypothermic cardiopulmonary bypass (CPB) is used during neonatal cardiac surgery. To elucidate potential risk factors for brain injury, diffuse optical spectroscopy, diffuse correlation spectroscopy, and cerebral microdialysis techniques were employed to monitor cerebral hemodynamics during mild hypothermic CPB in a swine model. Optical metrics were further compared with microdialysis metrics. Stable microdialysis metabolite levels, a significant decrease in CMRO2, and trending (but not significant) decreases in CBF and increases in OEF were observed. This suggests that the optical metrics may be more sensitive to neurologic injury during CPB than microdialysis.

Conference Presentation

Citation Download Citation

Emilie J. Benson, Lindsay E. Volk, Tiffany S. Ko, Jonathan P. Starr, Samy Belbegra, Wesley B. Baker, Jonah A. Padawer-Curry, Kristen N. Andersen, Alexander L. Schmidt, Thomas Hallowell, Yuxi Lin, Anna L. Roberts, Nile Delso, William P. Landis, Daniel J. Licht, Arjun G. Yodh, and Todd J. Kilbaugh "Effects of mild hypothermic cardiopulmonary bypass on cerebral hemodynamics: comparison of diffuse optical and cerebral microdialysis metrics in neonatal swine", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 116391F (5 March 2021); https://doi.org/10.1117/12.2579337

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Hemodynamics

Brain

Injuries

Oxygen

Tissue optics

Optical testing

Spectroscopy

Show All Keywords

Keywords/Phrases

Search In:

Publication Years