Neurosurgical shunting in neonatal hydrocephalus increased cerebral perfusion only in patients with elevated intracranial pressure

Wesley B. Baker; Tracy M. Flanders; Tiffany S. Ko; Kristen N. Andersen; Jharna Jahnavi; John J. Flibotte; Daniel J. Licht; Arjun G. Yodh; Brian R. White; Shih-Shan Lang; Gregory G. Heuer

doi:10.1117/12.2578813

5 March 2021 Neurosurgical shunting in neonatal hydrocephalus increased cerebral perfusion only in patients with elevated intracranial pressure

Wesley B. Baker, Tracy M. Flanders, Tiffany S. Ko, Kristen N. Andersen, Jharna Jahnavi, John J. Flibotte, Daniel J. Licht, Arjun G. Yodh, Brian R. White, Shih-Shan Lang, Gregory G. Heuer

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Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 1163917 (2021) https://doi.org/10.1117/12.2578813
Event: SPIE BiOS, 2021, Online Only

Abstract

Hydrocephalus is a disorder of cerebral spinal fluid (CSF) physiology that results in increased intracranial pressure (ICP). It is commonly treated via surgical placement of a shunt in the ventricles to divert CSF. Diffuse optical measurements of cerebral perfusion and oxygen extraction were acquired before and after surgical shunt placement in neonates with hydrocephalus. An invasive ICP measurement was made at the time of shunt placement. Shunting increased cerebral perfusion and decreased oxygen extraction only in infants with elevated ICP. This suggests abnormally low perfusion in patients with elevated ICP, and normal perfusion in patients without elevated ICP.

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Wesley B. Baker, Tracy M. Flanders, Tiffany S. Ko, Kristen N. Andersen, Jharna Jahnavi, John J. Flibotte, Daniel J. Licht, Arjun G. Yodh, Brian R. White, Shih-Shan Lang, and Gregory G. Heuer "Neurosurgical shunting in neonatal hydrocephalus increased cerebral perfusion only in patients with elevated intracranial pressure", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 1163917 (5 March 2021); https://doi.org/10.1117/12.2578813

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