A new multichannel broadband NIRS system for quantitative monitoring of brain hemodynamics and metabolism during seizures

Isabel De Roever; Aikaterini Vezyroglou; Peter Hebden; Rachel Thornton; Alan Worley; Mariana Alves; Emma Dean; Gemma Bale; Paola Pinti; J. Helen Cross; Ilias Tachtsidis

doi:10.1117/12.2527067

11 July 2019 A new multichannel broadband NIRS system for quantitative monitoring of brain hemodynamics and metabolism during seizures

Isabel De Roever, Aikaterini Vezyroglou, Peter Hebden, Rachel Thornton, Alan Worley, Mariana Alves, Emma Dean, Gemma Bale, Paola Pinti, J. Helen Cross, Ilias Tachtsidis

Author Affiliations +

Proceedings Volume 11074, Diffuse Optical Spectroscopy and Imaging VII; 1107406 (2019) https://doi.org/10.1117/12.2527067
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

We present a newly developed multichannel broadband NIRS (or bNIRS) system that has the capacity to measure changes in light attenuation of 308 NIR wavelengths (610nm to 918nm) simultaneously over 16 different brain locations. To achieve this the instrument uses a lens based spectrometer with a front-illuminated CCD that has a sensor size of 26.8x26mm. This large CCD detector allows the simultaneous binning of 16 detector fibres. The software uses the UCLn algorithm to quantify the changes in oxy-, deoxy- haemoglobin concentration (HbO₂, HHb) and oxidised cytochrome-coxidase (oxCCO) simultaneously over 16 different brain locations with 1second sampling rate. We demonstrate the use of the instrument in quantifying brain tissue oxygenation and metabolic activity simultaneously with electrical changes as measured with EEG in children with seizures.

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Isabel De Roever, Aikaterini Vezyroglou, Peter Hebden, Rachel Thornton, Alan Worley, Mariana Alves, Emma Dean, Gemma Bale, Paola Pinti, J. Helen Cross, and Ilias Tachtsidis "A new multichannel broadband NIRS system for quantitative monitoring of brain hemodynamics and metabolism during seizures", Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 1107406 (11 July 2019); https://doi.org/10.1117/12.2527067

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KEYWORDS

Brain

Sensors

CCD image sensors

Near infrared spectroscopy

Head

Charge-coupled devices

Hemodynamics

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