Mapping local and global interactions between parvalbumin inhibitory neurons and excitatory neurons over the cortex in awake mice

Xiaodan Wang; Annie R. Bice; Adam Q. Bauer

doi:10.1117/12.2650521

17 March 2023 Mapping local and global interactions between parvalbumin inhibitory neurons and excitatory neurons over the cortex in awake mice

Xiaodan Wang, Annie R. Bice, Adam Q. Bauer

Author Affiliations +

Proceedings Volume PC12366, Optogenetics and Optical Manipulation 2023; PC1236605 (2023) https://doi.org/10.1117/12.2650521
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Parvalbumin interneurons (PV-INs) are the largest subpopulation of GABAergic neurons. Recent evidence suggests transcallosal projections of PV-INs within primary motor, visual and auditory cortices. Whether transcallosal PV-INs feature prominently, and the extent to which their local influence affects global excitatory activity is unknown. We created a novel imaging system and mouse line for all-optical neuronal probing and readout to map local and global interactions between excitatory neurons and PV-INs over the cortex in awake mice. PV-INs extend inhibitory influences spanning several mm over the cortex and into more distant, ipsilateral regions. Further, we show region-specific interhemispheric inhibitory influences of PV-INs.

Conference Presentation

Citation Download Citation

Xiaodan Wang, Annie R. Bice, and Adam Q. Bauer "Mapping local and global interactions between parvalbumin inhibitory neurons and excitatory neurons over the cortex in awake mice", Proc. SPIE PC12366, Optogenetics and Optical Manipulation 2023, PC1236605 (17 March 2023); https://doi.org/10.1117/12.2650521

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