NPH Letters

Action potential block in neurons by infrared light

[+] Author Affiliations
Alex J. Walsh

National Research Council, JBSA Fort Sam Houston, Texas 78234, United States

Air Force Research Laboratory, Bioeffects Division, JBSA Fort Sam Houston, Texas 78234, United States

Gleb P. Tolstykh

General Dynamics Information Technology, JBSA Fort Sam Houston, Texas 78234, United States

Stacey Martens, Bennett L. Ibey, Hope T. Beier

Air Force Research Laboratory, Bioeffects Division, JBSA Fort Sam Houston, Texas 78234, United States

Neurophoton. 3(4), 040501 (Dec 01, 2016). doi:10.1117/1.NPh.3.4.040501
History: Received July 1, 2016; Accepted November 8, 2016
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Abstract.  Short infrared laser pulses (SILP) have many physiological effects on cells, including the ability to stimulate action potentials (APs) in neurons. Here, we show that SILPs can also reversibly block APs. Reversible AP block in hippocampal neurons was observed following SILP (0.26 to 0.96  J/cm2; 1.37 to 5.01 ms; 1869 nm) with the block persisting for more than 1 s with exposures greater than 0.69  J/cm2. AP block was sustained for 30 s with SILPs pulsed at 1 to 7 Hz. Full recovery of neuronal activity was observed 5 to 30 s post SILP exposure. These results indicate that SILP can be used for noncontact, reversible AP block. Due to the high spatial precision and noncontact manner of infrared light delivery, AP block by SILP (infrared neural inhibition) has the potential to transform medical care for sustained pain inhibition and suppression of unwanted nerve activity.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Alex J. Walsh ; Gleb P. Tolstykh ; Stacey Martens ; Bennett L. Ibey and Hope T. Beier
"Action potential block in neurons by infrared light", Neurophoton. 3(4), 040501 (Dec 01, 2016). ; http://dx.doi.org/10.1117/1.NPh.3.4.040501


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