Prof. Yang Yu Profile

Prof. Yang Yu

at Beijing Anzhen Hospital, Capital Medical Univ.

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SPIE Journal Paper | 27 January 2024 Open Access

Wide dynamic range measurement of blood flow in vivo using laser speckle contrast imaging

Hong Li Liu, Yuan Yuan, Li Han, Yong Bi, Wen Yuan Yu, Yang Yu

JBO, Vol. 29, Issue 01, 016009, (January 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.1.016009

KEYWORDS: Blood circulation, Laser speckle contrast imaging, Arteries, Speckle, In vivo imaging, Veins, Animals, Speckle pattern, Scattering, Biological imaging

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SignificanceLaser speckle contrast imaging (LSCI) is a real-time wide-field technique that is applied to visualize blood flow in biomedical applications. However, there is currently a lack of relevant research to demonstrate that it can measure velocities over a wide dynamic range (WDR), which is critical for monitoring much higher and more pulsatile blood flow in larger size myocardial vessels, such as the coronary artery bypass graft, and visualizing the spatio-temporal evolution of myocardial blood flow perfusion in cardiac surgery.AimWe aim to demonstrate that the LSCI technique enables measuring velocities over a WDR from phantom experiments to animal experiments. In addition, LSCI is preliminarily applied to imaging myocardial blood flow distribution in vivo on rabbits.ApproachPhantom and animal experiments are performed to verify that the LSCI method has the ability to measure blood velocities over a wide range. Our method is also validated by transit time flow measurement, which is the gold standard for blood flow measurement in cardiac surgery.ResultsOur method is demonstrated to measure the blood flow over a wide range from 0.2 to 635 mm/s. To validate the phantom results, the varying blood flow rate from 0 to 320 mm/s is detected in the rat carotid artery. Additionally, our technique also obtains blood flow maps of different myocardial vessels, such as superficial large/small veins, veins surrounded by fat, and myocardial deeper arteriole.ConclusionsOur study has the potential to visualize the spatio-temporal evolution of myocardial perfusion in coronary artery bypass grafting, which would be of great benefit for future research in the life sciences and clinical medicine.

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