Currently employed as a scientist at the UK Health Security Agency, he previously served as a Research Associate at the University of Edinburgh. Before that, he worked as a Postgraduate Researcher at the Applied Optics and Photonics Division of Heriot-Watt University, Edinburgh, UK, where he was honoured with the James Watt Scholarship. His primary focus was on developing an innovative laser tool for early-stage cancer surgeries in the colon and lungs. Notably, bowel and lung cancers are among the most prevalent types in the UK, ranking third and fourth, respectively, according to the Cancer Research Foundation UK. The surgical advancements he pursued involved leveraging high peak power operations of ultrafast lasers on tissue surfaces.

Syam Mohan P.M. earned an MSc degree in Electronics in 2008 and an M.Tech degree in Optoelectronics and Optical Communication in 2011 from Mahatma Gandhi University and the University of Kerala, India, respectively. His M.Tech project, conducted at the Central Glass and Ceramic Research Institute (CGCRI) in Kolkata, India, focused on fiber optic chemical sensors.

Between 2011 and 2014, he served as an Optics Engineer at Vinvish Technologies Pvt. Ltd. in India, which was the Development Centre for Nuphoton Technologies USA. In this role, he contributed to the design and development of photodynamic therapy lasers, supercontinuum lasers, and confocal microscopes, collaborating with esteemed institutions such as CSIR-CGCRI Kolkata, DBT Govt. of India, RCC Trivandrum, and ICMR India.

Subsequently, he joined the National Centre for Laser Applications (NCLA-NUIG) in Galway, Ireland, as a Researcher in Laser Technology from 2014 to 2015. His work here encompassed diverse areas such as bio-photonics (including projects like "Anti-biofilm technology for indwelling catheters using UV light" in collaboration with Teleflex Medical USA and "Ultrafast laser processing of FFR catheter tip" in collaboration with Medtronic.