Dr. Robert C. Atwood Profile

Dr. Robert C. Atwood

at Diamond Light Source Ltd

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Author

Publications (3)

Proceedings Article | 24 October 2024 Paper

Three-dimensional hard x-ray micro-tomographic imaging of the human palatal anatomy and gracilis muscle

Daphne Schönegg, Hans Deyhle, Georg Schulz, Christine Tanner, Sharif Ahmed, Robert Atwood, Andreas Mueller, Magdalena Müller-Gerbl, Szilvia Mezey, Richard Lieber, Ali Khounsary, Bert Müller

Proceedings Volume 13152, 1315229 (2024) https://doi.org/10.1117/12.3035601

KEYWORDS: Muscles, Anatomy, Head, Visualization, Tissues, Image segmentation, Biological imaging, Computed tomography, Synchrotron radiation imaging

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Palatoplasty in infants with cleft palate aims to reconstruct the intricate three-dimensional anatomy and restore the velopharyngeal function, which is essential for swallowing, speech, and ventilation of the middle ear through the opening of the Eustachian tube. The non-destructive analysis of the microarchitecture around the pterygoid hamulus using hard x-rays should enhance the existing knowledge from dissection and histological studies. Specifically, the micro-anatomical relationship between the palatine aponeurosis, the tendon of the tensor veli palatini muscle, and the pterygoid hamulus must be characterized to understand their structural relationship and functional implications. At the cellular level, the arrangement of fibers within muscle fascicles needs to be clarified. The right half of a historical plastinated infant cadaveric head was examined with two laboratory-based micro computed tomography (μCT) systems: phoenix|xray nanotom^® m for imaging of the entire specimen with a pixel size of 55μm; and Zeiss Xradia 610 Versa for local tomography with a pixel size of 3.4μm. Using synchrotron radiation-based microtomography, additional measurements were performed with a pixel size of 3.24μm. The resulting images were rigidly registered and analyzed. Automated threshold-based segmentation of bones and manual segmentation of muscles, tendons, and aponeurosis, were performed to visualize their topographic relationships in three dimensions. An unstained segment of a human gracilis muscle was examined using the Exciscope Polaris with a pixel size of 0.35μm, and the fiber architecture was visually inspected. Laboratory-based x-ray μCT systems are suitable for virtual-histology examination of soft tissues and visualization of subcellular structures therein. Synchrotron radiation-based μCT with phase retrieval provided additional contrast within the plastinated soft tissues. The findings of this study support the hypothesis that the palatal muscles form a complex muscle sling around the pterygoid hamulus, underscoring the importance of preserving this bony protuberance during cleft palate repair.

Proceedings Article | 14 October 2022 Open Access

Practical implementations of speckle-based phase-retrieval methods in Python and GPU for tomography

Nghia Vo, Hongchang Wang, Lingfei Hu, Tunhe Zhou, Marie-Christine Zdora, Hans Deyhle, Robert Atwood, Michael Drakopoulos

Proceedings Volume 12242, 122420E (2022) https://doi.org/10.1117/12.2636834

KEYWORDS: Speckle analysis, Phase contrast, Open source software, Tomography, X-ray imaging, Image processing

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Proceedings Article | 10 September 2019 Open Access

Preprocessing techniques for removing artifacts in synchrotron-based tomographic images

Nghia Vo, Robert Atwood, Michael Drakopoulos

Proceedings Volume 11113, 111131I (2019) https://doi.org/10.1117/12.2530324

KEYWORDS: Tomography, Algorithm development, Sensors, Detection and tracking algorithms, Distortion, Cameras, Imaging systems, Scattering, Scintillation, Photons

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