DUV light is of great importance in applications, including nanolithography, material science, and biology. Metasurfaces, comprising well-engineered nanoresonators, promise to improve DUV technologies due to their capability to manipulate light at the nanoscale. We present metasurfaces showing high-quality-factor resonance (high-Q) in the DUV range. We combined low-loss dielectric materials, resonance mode associated with the quasi-bound state in the continuum, and various device schemes to realize the DUV high-Q metasurfaces. We demonstrate metasurfaces with functionalities including imaging-based biosensing and high-Q optical charity. Fabrication and characterization of the high-Q metasurface will be reported. This work provides a platform to advance DUV nanophotonics in sensing, quantum optics, and nonlinear optics.
We showcase plasmonic metasurfaces employing silicon (Si) nanostructures tailored for deep ultraviolet (DUV) spectroscopy. Si exhibits plasmonic resonance owing to the photon-doping effect originating from interband transitions in the DUV range. Through careful design adjustments, our metasurface achieves strong field enhancement at ~260nm. We investigate potential applications of the reported Si void metasurfaces for surface-enhanced spectroscopy by leveraging the unique properties of our Si metasurface. This study expands the range of materials employed in DUV nanophotonics, unlocking opportunities across diverse fields such as biomedical analysis and nonlinear optics.
Blood lactic acid concentration is an important indicator for physiological functions. To develop a rapid and sensitive
measurement technique for monitoring blood lactic acid may provide a useful tool in clinical diagnosis. We proposed to
develop a microdialysis surface-enhanced Raman spectroscopy (microdialysis-SERS) approach to filter/reduce
interference from other large metabolites in blood and enhance the detection sensitivity for blood lactic acid. In this
study, a microdialysis probe was constructed using 13 kDa cut-off dialysis membrane. The dialysate was mixed with 50
nm Ag colloidal nanoparticles automatically in a micro-fluid chamber for SERS detection under blood microdialysis of
Sprague-Dawley rat. The linear range of SERS-lactic acid measurement is 10-5~3x10-4 M with R2 value of 0.99. The
optimal mixing flow rate of nanoparticles is 18 μl/min under microdialysis at constant flow rate (2 μl/min). Real time
lactic acid monitoring in vivo also has been demonstrated using microdialysis-SERS system.
Highly sensitive measurement of biomolecules is very important in clinical diagnosis and biomedical sensing. Spectroscopic methods have played important roles in biomedical sensing system developments. Recent development in surface enhanced Raman scattering (SERS) method has greatly enhanced the weak Raman signals of biomolecules and has provided great potentials for real time measurement of biomolecules of body fluid. In addition, Raman measurement has the advantage of not requiring extrinsic fluorescent marker for labeling purpose. In this study, we have pioneered in the development of SERS spectroscopic measurement technique for serum lactic acid, which is one of the most important metabolic parameter in blood. We have fabricated Ag colloidal nanoparticles to enhance the weak Raman signal of lactic acid in serum. The diameter of the Ag nanoparticle is 20 nm, the nanoparticles concentration is 109particles/ml. We have observed the SERS characteristic peak of lactic acid at 1285~1480cm-1 under 632.8 nm HeNe laser excitation. We have demonstrated the measurement of the lactic acid in filtered serum in the physiological concentration range 5x10-3~22x10-3 mole/L, which is hundred times lower than the detectible range using traditional Raman approach. The serum samples with were measured in a specially designed reflector type sample holder to form a multiple reflection of excitation laser through the sample, between a reflector and a notch filter. In conclusion, this research demonstrates the feasibility of using Ag SERS technique for measuring the lactic acid at physical concentration and establishes the platform technique for human body fluid measurements.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.