Dr. Pablo A. Valdes Quevedo Profile

Dr. Pablo A. Valdes Quevedo

Assistant Professor of Neurosurgery at The Univ. of Texas Medical Branch

SPIE Involvement:

Author

SPIE Journal Paper | 13 November 2024 Open Access

Hyperspectral imaging in neurosurgery: a review of systems, computational methods, and clinical applications

Alankar Kotwal, Vishwanath Saragadam, Joshua Bernstock, Alfredo Sandoval, Ashok Veeraraghavan, Pablo Valdés

JBO, Vol. 30, Issue 02, 023512, (November 2024) https://doi.org/10.1117/12.10.1117/1.JBO.30.2.023512

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SignificanceAccurate identification between pathologic (e.g., tumors) and healthy brain tissue is a critical need in neurosurgery. However, conventional surgical adjuncts have significant limitations toward achieving this goal (e.g., image guidance based on pre-operative imaging becomes inaccurate up to 3 cm as surgery proceeds). Hyperspectral imaging (HSI) has emerged as a potential powerful surgical adjunct to enable surgeons to accurately distinguish pathologic from normal tissues.AimWe review HSI techniques in neurosurgery; categorize, explain, and summarize their technical and clinical details; and present some promising directions for future work.ApproachWe performed a literature search on HSI methods in neurosurgery focusing on their hardware and implementation details; classification, estimation, and band selection methods; publicly available labeled and unlabeled data; image processing and augmented reality visualization systems; and clinical study conclusions.ResultsWe present a detailed review of HSI results in neurosurgery with a discussion of over 25 imaging systems, 45 clinical studies, and 60 computational methods. We first provide a short overview of HSI and the main branches of neurosurgery. Then, we describe in detail the imaging systems, computational methods, and clinical results for HSI using reflectance or fluorescence. Clinical implementations of HSI yield promising results in estimating perfusion and mapping brain function, classifying tumors and healthy tissues (e.g., in fluorescence-guided tumor surgery, detecting infiltrating margins not visible with conventional systems), and detecting epileptogenic regions. Finally, we discuss the advantages and disadvantages of HSI approaches and interesting research directions as a means to encourage future development.ConclusionsWe describe a number of HSI applications across every major branch of neurosurgery. We believe these results demonstrate the potential of HSI as a powerful neurosurgical adjunct as more work continues to enable rapid acquisition with smaller footprints, greater spectral and spatial resolutions, and improved detection.

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Proceedings Article | 10 March 2015 Paper

Real-time quantitative fluorescence imaging using a single snapshot optical properties technique for neurosurgical guidance

Pablo Valdes, Joseph Angelo, Sylvain Gioux

Proceedings Volume 9305, 93050J (2015) https://doi.org/10.1117/12.2085051

KEYWORDS: Luminescence, Optical properties, Tissue optics, Imaging systems, Real time imaging, Absorption, Scattering, Tissues, Diffuse reflectance spectroscopy, Optical imaging

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SPIE Journal Paper | 4 February 2015 Open Access

Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance

Kolbein Kolste, Stephen Kanick, Pablo Valdés, Michael Jermyn, Brian Wilson, David Roberts, Keith Paulsen, Frederic Leblond

JBO, Vol. 20, Issue 02, 026002, (February 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.2.026002

KEYWORDS: Luminescence, Optical properties, Tissue optics, Error analysis, Tissues, Monte Carlo methods, Tumors, Brain, Scattering, Optical imaging

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Proceedings Article | 20 March 2014 Paper

Quantitative spectrally resolved intraoperative fluorescence imaging for neurosurgical guidance in brain tumor surgery: pre-clinical and clinical results

Pablo Valdés, Valerie Jacobs, Frederic Leblond, Brian Wilson, Keith Paulsen, David Roberts

Proceedings Volume 8928, 892809 (2014) https://doi.org/10.1117/12.2039090

KEYWORDS: Luminescence, Tumors, Imaging systems, Tissue optics, Microscopes, Surgery, Signal detection, Brain, Signal attenuation, Tissues

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SPIE Journal Paper | 4 May 2012 Open Access

Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models

Soren Konecky, Tyler Rice, Bruce Tromberg, Chris Owen, Pablo Valdes, David Roberts, Kolbein Kolste, Frederic Leblond, Keith Paulsen, Brian Wilson

JBO, Vol. 17, Issue 5, 056008, (May 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.5.056008

KEYWORDS: Luminescence, Tumors, Tomography, Tissue optics, Scattering, Skull, Tissues, In vivo imaging, Brain, Optical properties

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SPIE Journal Paper | 1 November 2011 Open Access

Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery

Pablo Valdes, Frederic Leblond, Keith Paulsen, Anthony Kim, Brian Wilson, Olga Conde, Brent Harris, David Roberts

JBO, Vol. 16, Issue 11, 116007, (November 2011) https://doi.org/10.1117/12.10.1117/1.3646916

KEYWORDS: Tumors, Luminescence, Tissue optics, Tissues, Diagnostics, Scattering, Algorithm development, Surgery, Absorption, Brain

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Proceedings Article | 18 February 2011 Paper

ALA-induced PpIX spectroscopy for brain tumor image-guided surgery

Pablo Valdes, Frederic Leblond, Anthony Kim, Brent Harris, Brian Wilson, Keith Paulsen, David Roberts

Proceedings Volume 7883, 78833P (2011) https://doi.org/10.1117/12.875016

KEYWORDS: Tumors, Luminescence, Tissues, Diagnostics, Brain, Tissue optics, Microscopes, Spectroscopy, Reflectivity, Surgery

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Proceedings Article | 18 February 2011 Paper

ALA-induced PpIX fluorescence in epileptogenic tissue

Jonathan Kleen, Pablo Valdes, Brent Harris, Gregory Holmes, Keith Paulsen, David Roberts

Proceedings Volume 7883, 78833S (2011) https://doi.org/10.1117/12.879864

KEYWORDS: Luminescence, Tissues, Epilepsy, Surgery, Brain, Animal model studies, Magnetic resonance imaging, Tumors, Visualization, Single photon emission computed tomography

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Proceedings Article | 24 February 2010 Paper

Graphical user interfaces for simulation of brain deformation in image-guided neurosurgery

Xiaoyao Fan, Songbai Ji, Pablo Valdes, David Roberts, Alex Hartov, Keith Paulsen

Proceedings Volume 7625, 762535 (2010) https://doi.org/10.1117/12.844036

KEYWORDS: Brain, Neuroimaging, Data modeling, Image segmentation, Image registration, Ultrasonography, Magnetic resonance imaging, Human-machine interfaces, Visualization, 3D image processing

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Proceedings Article | 13 March 2009 Paper

Brain tumor resection guided by fluorescence imaging and MRI image guidance

Pablo Valdes, Brent Harris, Frederic Leblond, Kathryn Fontaine, Songbai Ji, Brian Pogue, Alex Hartov, David Roberts, Keith Paulsen

Proceedings Volume 7261, 726103 (2009) https://doi.org/10.1117/12.813868

KEYWORDS: Magnetic resonance imaging, Luminescence, Tissues, Tumors, Microscopes, Brain, Gadolinium, Surgery, Image analysis, Image enhancement

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Proceedings Article | 24 February 2009 Paper

Brain tumor resection guided by fluorescence imaging

Frederic Leblond, Kathryn Fontaine, Pablo Valdes, Songbai Ji, Brian Pogue, Alex Hartov, David Roberts, Keith Paulsen

Proceedings Volume 7164, 71640M (2009) https://doi.org/10.1117/12.808928

KEYWORDS: Tumors, Luminescence, Surgery, Microscopes, Tissues, Brain, Magnetic resonance imaging, Navigation systems, Neuroimaging, Clinical trials

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Showing 5 of 11 publications

Conference Committee Involvement (3)

Clinical and Translational Neurophotonics

28 January 2017 | San Francisco, California, United States

Clinical and Translational Neurophotonics

13 February 2016 | San Francisco, California, United States

Optical Techniques in Neurosurgery, Brain Imaging, and Neurobiology

7 February 2015 | San Francisco, California, United States

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