Dr. Nikolaos C. Deliolanis Profile

Dr. Nikolaos C. Deliolanis

Group Leader at Univ of Heidelberg

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Proceedings Article | 14 June 2013 Paper

In vivo mouse imaging using frequency domain optoacoustic tomography

Stephan Kellnberger, Nikolaos Deliolanis, Daniel Queirós, George Sergiadis, Vasilis Ntziachristos

Proceedings Volume 8800, 88000A (2013) https://doi.org/10.1117/12.2032937

KEYWORDS: Tomography, In vivo imaging, Modulation, Signal detection, Scanners, Continuous wave operation, Photography, Absorption, Acoustics, Data acquisition

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SPIE Journal Paper | 2 May 2013 Open Access

Fluorescence background subtraction technique for hybrid fluorescence molecular tomography/x-ray computed tomography imaging of a mouse model of early stage lung cancer

Angelique Ale, Vladimir Ermolayev, Nikolaos Deliolanis, Vasilis Ntziachristos

JBO, Vol. 18, Issue 05, 056006, (May 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.5.056006

KEYWORDS: Luminescence, Data acquisition, Tumors, CCD cameras, Tissues, Sensors, Imaging systems, Lung cancer, In vivo imaging, Lung

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Proceedings Article | 23 February 2012 Paper

Real-time imaging of renal clearance using multispectral optoacoustic tomography

Stefan Morscher, Neal Burton, Adrian Taruttis, Nikolaos Deliolanis, Daniel Razansky, Vasilis Ntziachristos

Proceedings Volume 8223, 822330 (2012) https://doi.org/10.1117/12.907975

KEYWORDS: Tomography, Real time imaging, Kidney, Tissues, Ultrasonography, Absorption, Tissue optics, In vivo imaging, Luminescence, Transducers

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Proceedings Article | 20 June 2011 Paper

Spectral unmixing using component analysis in multispectral optoacoustic tomography

Stefan Morscher, Jürgen Glatz, Nikolaos Deliolanis, Andreas Buehler, Athanasios Sarantopoulos, Daniel Razansky, Vasilis Ntziachristos

Proceedings Volume 8089, 80890R (2011) https://doi.org/10.1117/12.889415

KEYWORDS: Absorption, Independent component analysis, Tomography, Tissue optics, Tissues, Principal component analysis, Luminescence, Photoacoustic spectroscopy, Blood, Photoacoustic tomography

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Proceedings Article | 28 February 2011 Paper

Blind spectral unmixing to identify molecular signatures of absorbers in multispectral optoacoustic tomography

Stefan Morscher, Juergen Glatz, Nikolaos Deliolanis, Andreas Buehler, Daniel Razansky, Vasilis Ntziachristos

Proceedings Volume 7899, 78993D (2011) https://doi.org/10.1117/12.875290

KEYWORDS: Absorption, Independent component analysis, Tissue optics, Tomography, Principal component analysis, Tissues, Luminescence, Biomedical optics, Photoacoustic spectroscopy, Ultrasonography

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Proceedings Article | 17 February 2011 Paper

Double-cladding-fiber-based detection system for intravascular mapping of fluorescent molecular probes

R. Nika Razansky, Amir Rozental, Mathias Mueller, Nikolaos Deliolanis, Farouc Jaffer, Alexander Koch, Vasilis Ntziachristos

Proceedings Volume 7894, 78940K (2011) https://doi.org/10.1117/12.874653

KEYWORDS: Sensors, Cladding, Luminescence, GRIN lenses, In vivo imaging, Fluorescence spectroscopy, Waveguides, Inflammation, Single mode fibers, Polishing

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Early detection of high-risk coronary atherosclerosis remains an unmet clinical challenge. We have previously demonstrated a near-infrared fluorescence catheter system for two-dimensional intravascular detection of fluorescence molecular probes [1]. In this work we improve the system performance by introducing a novel high resolution sensor. The main challenge of the intravascular sensor is to provide a highly focused spot at an application relevant distance on one hand and a highly efficient collection of emitted light on the other. We suggest employing a double cladding optical fiber (DCF) in combination with focusing optics to provide a sensor with both highly focused excitation light and highly efficient fluorescent light collection. The excitation laser is coupled into the single mode core of DCF and guided through a focusing element and a right angle prism. The resulting side-fired beam exhibits a small spot diameter (50 μm) throughout a distance of up to 2 mm from the sensor. This is the distance of interest for intravascular coronary imaging application, determined by an average human coronary artery diameter. At the blood vessel wall, an activatable fluorescence molecular probe is excited in the diseased lesions. Next light of slightly shifted wavelength emits only in the places of the inflammations, associated with dangerous plaques [2]. The emitted light is collected by the cladding of the DCF, with a large collection angle (NA=0.4). The doublecladding acts as multimodal fiber and guides the collected light to the photo detection elements. The sensor automatically rotates and pulled-back, while each scanned point is mapped according to the amount of detected fluorescent emission. The resulting map of fluorescence activity helps to associate the atherosclerotic plaques with the inflammation process. The presented detection system is a valuable tool in the intravascular plaque detection and can help to differentiate the atherosclerotic plaques based on their biological activity, identify the ones that prone to rupture and therefore require more medical attention.

SPIE Journal Paper | 1 May 2010 Open Access

Errata: In-vivo imaging of murine tumors using complete-angle projection fluorescence molecular tomography

Nikolaos Deliolanis, Joshua Dunham, Thomas Wurdinger, Jose-Luiz Figueiredo, Bakhos Tannous, Vasilis Ntziachristos

JBO, Vol. 15, Issue 03, 039801, (May 2010) https://doi.org/10.1117/12.10.1117/1.3449540

KEYWORDS: In vivo imaging, Tumors, Luminescence, Fluorescence tomography, Tomography, Molecular imaging, Medical research, Medical imaging

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Proceedings Article | 24 February 2010 Paper

Multiparametric optimization of multispectral optoacoustic tomography for deep tissue imaging

Jürgen Glatz, Nikolaos Deliolanis, Lu Ding, Adrian Taruttis, Amir Rosenthal, Ralf Schulz, Daniel Razansky, Vasilis Ntziachristos

Proceedings Volume 7564, 75642Z (2010) https://doi.org/10.1117/12.842101

KEYWORDS: Proteins, Fluorescent proteins, Tissue optics, Tissues, Tomography, Photoacoustic spectroscopy, Absorption, Light wave propagation, Green fluorescent protein, Deep tissue imaging

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SPIE Journal Paper | 1 May 2009 Open Access

In-vivo imaging of murine tumors using complete-angle projection fluorescence molecular tomography

Nikolaos Deliolanis, Joshua Dunham, Thomas Wurdinger, Jose-Luiz Figueiredo, Tannous Bakhos, Vasilis Ntziachristos

JBO, Vol. 14, Issue 03, 030509, (May 2009) https://doi.org/10.1117/12.10.1117/1.3149854

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SPIE Journal Paper | 1 July 2008 Open Access

Performance of the red-shifted fluorescent proteins in deep-tissue molecular imaging applications

Nikolaos Deliolanis, Randa Kasmieh, Thomas Wurdinger, Bakhos Tannous, Khalid Shah, Vasilis Ntziachristos

JBO, Vol. 13, Issue 04, 044008, (July 2008) https://doi.org/10.1117/12.10.1117/1.2967184

KEYWORDS: Luminescence, Green fluorescent protein, Tissue optics, Tissues, In vivo imaging, Fluorescent proteins, Proteins, Absorption, Signal attenuation, Tumors

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Proceedings Article | 12 July 2007 Paper

360° free space fluorescence molecular tomography using silhouette surface reconstruction

T. Lasser, N. Deliolanis, A. Soubret, J. Ripoll, V. Ntziachristos

Proceedings Volume 6629, 662910 (2007) https://doi.org/10.1117/12.729417

KEYWORDS: Luminescence, Natural surfaces, Fluorescence tomography, Tomography, 3D acquisition, 3D image processing, Tissue optics, In vivo imaging, Reconstruction algorithms, Free space

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Showing 5 of 11 publications

Conference Committee Involvement (2)

Molecular Imaging III

22 May 2011 | Munich, Germany

Laser Applications in Life Sciences

9 June 2010 | Oulu, Finland

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