Photoacoustic imaging offers high spatial resolution, imaging depth, and molecular information, emerging as a promising biomedical imaging modality. In particular, when using exogenous contrast, the advantages of photoacoustic imaging can be more effectively utilized in preclinical and clinical studies. We provide a novel approach to screen and identify efficient photoacoustic performance as contrast agents of the metals. To accomplish this, we introduce a novel figure of merit that quantifies the potential performance of contrast agents. As a result of the quantification, we discover that Ti nanodiscs outperform Pt nanodiscs in terms of photoacoustic ability, which shows a similar level to Au nanodiscs. We compare these results by performing a photoacoustic phantom imaging experiment. The photoacoustic performance of the three materials is compared by comparing the signal intensity of the materials measured on the photoacoustic image for various wavelengths. The imaging results further support our findings, demonstrating the superior performance of Ti nanodiscs as contrast agents.
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