Mr. Ming-Lin You Profile

Ming-Lin You

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Proceedings Article | 10 May 2019 Paper

96-well capped gold nanoslits for backside-reflection plasmonic biosensing

Kuang-Li Lee, Po-Cheng Tsai, Meng-Lin You, Pei-Kuen Wei

Proceedings Volume 11007, 1100704 (2019) https://doi.org/10.1117/12.2518423

KEYWORDS: Gold, Reflection, Nanostructures, Refractive index, Plasmonics, Biosensing, Proteins, Interfaces, Water, Sensors

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A nanostructure-based plasmonic biochip with the same size as standard 96-well plates for backside reflection-type biosensing was proposed and validated through analyses of biological interactions. The capped gold nanoslit arrays were fabricated on a polycarbonate plastic film using a rapid hot embossing nanoimprint lithography process. The optical properties of capped gold nanoslits with different structure parameters in backside reflection geometry were studied; their refractive index (bulk) and surface (thickness) sensitivities were verified. By changing the cavity length, the coupling between a broadband cavity resonance and a narrowband surface plasmon resonance mode results in an asymmetric Fano resonance in the reflection spectra. The coupling mode is able to enhance the thickness sensitivity by a factor of 2.4 with wavelength interrogation. The bulk and thickness sensitivities were 454 nm/RIU and 1.14 nm/nm, respectively. The protein-protein interaction experiments verified the sensing capabilities and high sensitivity of the capped nanostructures; a limit of detection (LOD) of 2 ng/mL IgA was achieved. Such a multi-well plate with backside reflection-type geometry, decoupling the optical paths, allows for sensing with opaque, bubbly or highly scattering liquids and benefits multiple sensing applications in the biotechnology and agricultural products.

Proceedings Article | 28 April 2017 Paper

Micro-ellipsometry imaging of biostructures aided by 1D reflection grating

C. H. Chan, Y. D. Chen, M. Khaleel, M. L. You, P. K. Wei, Y. C. Chang

Proceedings Volume 10209, 102090X (2017) https://doi.org/10.1117/12.2266459

KEYWORDS: Ellipsometry, Sensors, Reflection, Objectives, Nanostructures, Imaging systems, Diffraction gratings, Diffraction, Plasmonics, Biosensing, Light scattering, Metals, Polymers, Reflectivity

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We performed experimental measurements and theoretical simulation based on an efficient half-space Green’s function method to investigate the diffraction patterns of light scattered from the biological structure on 1D reflection grating made of metal and polymer. The 1D grating provides higher-order reflected light, which can boost the image signal for off-specular reflection. This can facilitate the micro-ellipsometry imaging experiment when an incident angle of light is at a large angle, while the detection camera is placed at the upright position. The micro-ellipsometry images for s- and p-polarized reflectance and their phase difference (Rs, Rp, and Δ) was taken by a modified Optrel MULTISKOP system with rotating compensator configuration for various angles of incidence and wavelengths ranging from 450nm to 750nm. By using an 80X objective lens, the pixel size for our image is around 164nm. We can further increase the magnification and the numerical aperture by using a substrate collocated with a homemade acrylic resin lens, and the pixel size can be reduced to 50 nm. Based on the above, we study the optical properties of metallic/dielectric nanostructures and nearby biological systems including bacteria, and cancer cells via an imaging micro-ellipsometer combined with detailed theoretical modeling. By using specular and off-specular micro-ellipsometry imaging, we can achieve sufficient sensitivity to collect signals from a small area (around 10μm X 10μm and obtain a 3D image mapping of the morphology and dielectric properties of the biological system of interest.

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