Prof. Meng-Tsan Tsai Profile

Prof. Meng-Tsan Tsai

Professor at Chang Gung Univ

SPIE Involvement:

Author

Publications (37)

Proceedings Article | 20 September 2023 Paper

Feature identification of skin diseases and laser therapy with a portable optical coherence imaging system

Chien-Yu Lin, Chau Yee Ng, Meng-Tsan Tsai

Proceedings Volume 12608, 1260810 (2023) https://doi.org/10.1117/12.3007921

KEYWORDS: Skin, Optical coherence tomography, Laser therapeutics, Diseases and disorders, Portability, In vivo imaging, Imaging systems, Image segmentation, Picosecond phenomena, Optical coherence

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Proceedings Article | 11 August 2023 Paper

In vivo skin imaging and laser therapy observation with ultrahigh-resolution optical coherence tomography

Tai-Ang Wang, Yin-Shen Cheng, Hsiang-Chieh Lee, Chau Yee Ng, Meng-Tsan Tsai

Proceedings Volume 12632, 1263225 (2023) https://doi.org/10.1117/12.2670560

KEYWORDS: Laser therapeutics, Skin, In vivo imaging, Optical coherence tomography, Tissues, Laser microstructuring, Diseases and disorders, Dermatology, Quantitative analysis, Laser soldering

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Proceedings Article | 11 August 2023 Paper

Ex vivo study of photothermolysis induced by laser therapy with dynamic optical coherence tomography

Yin-Shen Cheng, Tai-Ang Wang, Hsiang-Chieh Lee, Meng-Tsan Tsai

Proceedings Volume 12632, 1263221 (2023) https://doi.org/10.1117/12.2674964

KEYWORDS: Optical coherence tomography, Tissues, Laser therapeutics, Laser ablation, Fiber lasers, Signal processing, Raman spectroscopy, Photothermal effect, Tissue optics, Data processing

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Proceedings Article | 17 March 2023 Presentation

In vivo study of skin photodamage induced by a picosecond laser with a portable ultrahigh-resolution optical coherence tomography

Yin-Shen Cheng, Tai-Ang Wang, Hsiang-Chieh Lee, Chau Yee Ng, Meng-Tsan Tsai

Proceedings Volume PC12352, PC123520E (2023) https://doi.org/10.1117/12.2649521

KEYWORDS: Optical coherence tomography, Picosecond phenomena, Skin, In vivo imaging, Imaging systems, Laser optics, Tissue optics, System identification, Spectral resolution, Light sources

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Proceedings Article | 16 March 2023 Presentation

Early detection of caries with ultrahigh-resolution optical coherence tomography (Conference Presentation)

Tai-Ang Wang, Hsiang-Chieh Lee, Yen-Li Wang, Meng-Tsan Tsai

Proceedings Volume PC12391, PC1239112 (2023) https://doi.org/10.1117/12.2649102

KEYWORDS: Optical coherence tomography, Dental caries, Calculus, Visualization, Image resolution, Stereoscopy, Radiography, Diagnostics

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Proceedings Article | 14 March 2023 Presentation + Paper

Development of an automatic algorithm enabling layer segmentation and optical characteristic analysis in skin optical coherence tomography imaging

Ting-Hao Chen, Yu-Hsuan Lee, Chau Yee Ng, Meng-Tsan Tsai, Cheng-Kuang Lee, Hsiang-Chieh Lee

Proceedings Volume 12352, 1235203 (2023) https://doi.org/10.1117/12.2649491

KEYWORDS: Skin, Optical coherence tomography, Algorithm development, Tissue optics, Signal attenuation, Interfaces, Coherence imaging, Image segmentation, Evolutionary algorithms, Tissues

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Proceedings Article | 7 March 2022 Presentation

Quantitative comparison of photothermal effects induced by pulsed lasers with optical coherence tomography

Tai-Ang Wang, Hsiang-Chieh Lee, Chau Yee Ng, Meng-Tsan Tsai

Proceedings Volume 11934, 119340C (2022) https://doi.org/10.1117/12.2609281

KEYWORDS: Optical coherence tomography, Pulsed laser operation, Photothermal effect, Skin, Laser optics, Laser therapeutics, Carbon dioxide lasers, Signal attenuation, Tissue optics, Spatial resolution

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Proceedings Article | 3 March 2022 Presentation + Paper

High-speed optical coherence tomography imaging with a tunable HCG-VCSEL light source at the 1060nm wavelength window

Ting-Yen Tsai, Ting-Hao Chen, Hung-Kai Chen, Chuan-Bor Chueh, Dalila Ellafi, Chris Chase, Hao-Chung Kuo, Meng-Tsan Tsai, Michael C. Y. Huang, Hsiang-Chieh Lee

Proceedings Volume 12020, 120200F (2022) https://doi.org/10.1117/12.2608803

KEYWORDS: Optical coherence tomography, Vertical cavity surface emitting lasers, Light sources, Microelectromechanical systems, Calibration, Imaging systems, Interferometers, Mirrors, Coherence imaging, Wavelength tuning

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Proceedings Article | 27 October 2021 Paper

High-speed and wide-field endoscopic optical coherence tomography imaging of the oral mucosa with a micromotor imaging catheter and polarization diversity detection

Ting-Yen Tsai, Chuan-Bor Chueh, Ting-Hao Chen, Meng-Shan Wu, Meng-Tsan Tsai, Hsiang-Chieh Lee

Proceedings Volume 11925, 1192516 (2021) https://doi.org/10.1117/12.2615841

KEYWORDS: Optical coherence tomography, Cancer, Endoscopy, Coherence imaging, Polarization, Imaging systems, Tissues, Optical imaging, Signal detection, Angiography

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Proceedings Article | 27 October 2021 Paper

Investigation of laser-indued thermal effect with laser speckle contrast imaging

Wei-En Sia, Cheng-Yu Lee, Tai-Ang Wang, Wen-Ru Chen, Feng-Yu Chang, Meng-Tsan Tsai

Proceedings Volume 11925, 119251M (2021) https://doi.org/10.1117/12.2615969

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Proceedings Article | 27 October 2021 Paper

OCT/OCTA-guided laser ablation for tumor treatment

Meng-Tsan Tsai, Hao-Wei Huang, Wen-Ju Chen, Tai-Ang Wang, Feng-Yu Chang

Proceedings Volume 11925, 1192503 (2021) https://doi.org/10.1117/12.2615400

KEYWORDS: Tumors, Laser ablation, Optical coherence tomography, Laser therapeutics, Semiconductor lasers, Laser tissue interaction, Continuous wave operation, Pulsed laser operation, Tissues, Skin

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Laser ablation has come an alternative solution for tumor treatment, and it can be used to remove or shrink tumor tissue. In the previous reports, the pulsed lasers are the most common laser as the light source of laser treatment due to the controllable thermal damage, but it is difficult to use continuous-wave (CW) lasers for tissue ablation because of unpredictable laser damage and thermal effect. Typically, the CW lasers are cost effective in comparison to the pulsed lasers. Additionally, it is also challenging to accurately identify the tumor region for laser therapy to avoid the extra damage on the surrounding tissue. To overcome the limitation of using CW lasers for tumor therapy and to identify the tumor region for laser therapy, an imaging method to monitor the thermal effect induced by the CW laser in real time and to distinguish the tumor region is required. In this study, we develop an optical coherence tomography (OCT)/optical coherence angiography (OCA)-guided laser treatment system with a CW laser diode which is significantly much cheaper than pulsed lasers. To investigate the laser-induced thermal damage, a method based on the analysis of the OCT backscattered intensity is proposed. Moreover, the thermal effect on the vessels of skin is also quantitatively investigated. However, to accurately identify the tumor region, OCT and OCA results could be effective indicators according to the difference of normal and tumor tissue in the backscattered intensity and the vascular distribution. The automatic and objective identification of tumor region can be achieved based on deep learning, enabling to discriminate the tumor tissue with a high sensitivity of 97 %. Finally, the integrated system and the proposed method are implemented for the treatment of skin tumor on the mouse model. The results illustrate that the OCT/OCA-guided laser ablation system can accurately and effectively remove tumor tissues with controllable photodamage. Moreover, the system cost may be significantly reduced by using the continuous wave laser diode.

Proceedings Article | 27 October 2021 Paper

Characterization of vitiligo with optical coherence tomography

Po-Hsu Su, Bo-Huei Huang, Chau Yee Ng, Feng-Yu Chang, Meng-Tsan Tsai

Proceedings Volume 11925, 119251N (2021) https://doi.org/10.1117/12.2615970

KEYWORDS: Optical coherence tomography, Skin, Tissue optics, Spectroscopy, Image resolution, Acoustics, Sun, Optical imaging, Light sources, Interferometers

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Proceedings Article | 27 October 2021 Paper

Graphics Processing Unit (GPU) accelerated microvascular imaging framework with optical coherence tomography (OCT) and OCT angiography techniques

Yu-Ling Chen, Ting-Hao Chen, Ting-Yen Tsai, Chuan-Bor Chueh, Yi-Chun Wu, Meng-Tsan Tsai, Cheng-Kuang Lee, Hsiang-Chieh Lee

Proceedings Volume 11925, 1192517 (2021) https://doi.org/10.1117/12.2615846

KEYWORDS: Optical coherence tomography, Graphics processing units, Angiography, Optical imaging, Biomedical optics, Image processing, Doppler tomography, Blood, Algorithm development, Visualization

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Proceedings Article | 5 March 2021 Presentation

Computational multi-directional optical coherence tomography for visualizing the microstructural directionality of the tissue

Daisuke Oida, Kensuke Oikawa, Tai-Ang Wang, Meng-Tsan Tsai, Shuichi Makita, Yoshiaki Yasuno

Proceedings Volume 11630, 116301C (2021) https://doi.org/10.1117/12.2577970

KEYWORDS: Optical coherence tomography, Signal processing, Visualization, Tissue optics, Tissues, Spatial frequencies, Turbulence, Statistical analysis, Breast

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Proceedings Article | 15 June 2020 Paper

Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring

Wen-Ju Chen, Feng-Yu Chang, Meng-Tsan Tsai

Proceedings Volume 11521, 1152106 (2020) https://doi.org/10.1117/12.2573215

KEYWORDS: Optical coherence tomography, Tissues, Laser therapeutics, Tumors, Laser tissue interaction, Semiconductor lasers, Skin, Continuous wave operation, Backscatter, Laser ablation

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Proceedings Article | 15 June 2020 Paper

Real-time functional optical coherence tomography imaging

Teng-Chieh Chang, Ting-Hao Chen, Ting-Yen Tsai, Chuan-Bor Chueh, Yin-Peng Huang, Meng-Tsan Tsai, Cheng-Kuang Lee, Hsiang-Chieh Lee

Proceedings Volume 11521, 115210D (2020) https://doi.org/10.1117/12.2573230

KEYWORDS: Optical coherence tomography, Imaging systems, Coherence imaging, Optical imaging, Graphics processing units, Image processing, Human-machine interfaces, Data processing, Biomedical optics, Parallel processing

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Proceedings Article | 6 March 2020 Presentation

Quantitative spectroscopic comparison of the optical properties of the mouse cochlear microstructures using optical coherence tomography at 1.3 µm and 1 µm wavelength regimes (Conference Presentation)

Ting-Yen Tsai, Ting Hao Chen, Hsin-Chien Chen, Hao Wang, Yin-Peng Huang, Teng-Chieh Chang, Yu-Wei Chang, Yi-Ping Hung, Meng-Tsan Tsai, Chih-Hung Wang, Hsiang-Chieh Lee

Proceedings Volume 11213, 1121304 (2020) https://doi.org/10.1117/12.2546252

KEYWORDS: Optical coherence tomography, Optical properties, Spectroscopy, Image resolution, Imaging systems, Spectroscopes, In vivo imaging, Ear, Vestibular system, Visualization

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Proceedings Article | 21 February 2020 Presentation + Paper

Virtual multi-directional optical coherence tomography

Daisuke Oida, Kensuke Oikawa, Tai-Ang Wang, Meng-Tsan Tsai, Shuichi Makita, Yoshiaki Yasuno

Proceedings Volume 11228, 112281G (2020) https://doi.org/10.1117/12.2548902

KEYWORDS: Optical coherence tomography, Visualization, Tissues, Tissue optics, Spatial frequencies, Optical coherence microscopy

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Proceedings Article | 19 July 2019 Paper

Characteristics of brain tumor with optical coherence tomography

Chia-Heng Wu, Wen-Ju Chen, Cihun-Siyong Alex Gong, Meng-Tsan Tsai

Proceedings Volume 11078, 110781Q (2019) https://doi.org/10.1117/12.2526570

KEYWORDS: Brain, Tumors, Optical coherence tomography, Tissues, Angiography, Surgery, Tissue optics, Algorithm development, Neuroimaging, In vivo imaging

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Proceedings Article | 24 April 2018 Paper

Development of dual-wavelength microscopic laser speckle contrast imaging system

Cheng-Yu Lee, Meng-Tsan Tsai

Proceedings Volume 10711, 107111G (2018) https://doi.org/10.1117/12.2317069

KEYWORDS: Speckle, Laser speckle contrast imaging, Imaging systems, CCD cameras, Light sources, Image analysis, Absorption, Analytical research, Image quality, Reflection

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Proceedings Article | 24 April 2018 Paper

Monitoring protein-related degeneration of Drosophila eyes with optical coherence tomography

Chia-Heng Wu, Cihun-Siyong Alex Gong, Min-Tsan Su, Meng-Tsan Tsai

Proceedings Volume 10711, 1071113 (2018) https://doi.org/10.1117/12.2319077

KEYWORDS: Optical coherence tomography, Eye, Eye models, Biomedical optics, Genetics, Biology, Heart, Alzheimer's disease, 3D microstructuring, Inspection

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Proceedings Article | 24 April 2018 Paper

Evaluation of photodamage with polarization-sensitive optical coherence tomography

Trung Nguyen Hoang, Cheng-Yu Lee, Meng-Tsan Tsai

Proceedings Volume 10711, 107110B (2018) https://doi.org/10.1117/12.2316799

KEYWORDS: Optical coherence tomography, Polarization, Tissues, Skin, Birefringence, Laser induced damage, Phase measurement

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Proceedings Article | 15 March 2018 Presentation

Evaluating cell death process with the M-mode scan of optical coherence tomography (Conference Presentation)

Shuai Chen, Yulu He, Cheng-Che Hsieh, Wei-Hsiang Hua, Meng-Chun Low, Yu-Hsuan Tsai, Cheng-Jin Cai, Meng-Tsan Tsai, Hsiang-Chieh Lee, Yean-Woei Kiang, Chih-Chung Yang

Proceedings Volume 10506, 1050606 (2018) https://doi.org/10.1117/12.2287682

KEYWORDS: Cell death, Optical coherence tomography, Bioalcohols, Microfluidics, Optical scanning systems, Calibration, Gold, Scattering, Signal to noise ratio, Flow cytometry

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Proceedings Article | 14 March 2018 Presentation

Investigating skin damage induced by UV light with optical coherence tomography (Conference Presentation)

Wen-Ju Chen, Wei-Chuan Chen, Cheng-Yu Lee, Chih-Hsun Yang, Meng-Tsan Tsai

Proceedings Volume 10467, 104670A (2018) https://doi.org/10.1117/12.2288714

KEYWORDS: Ultraviolet radiation, Skin, Optical coherence tomography, Sun, Diagnostics, Imaging systems, Genetics, Skin cancer, 3D image processing, 3D microstructuring

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Proceedings Article | 24 April 2017 Presentation

Observation of the death process of cancer cells killed through surface plasmon resonance of gold nanoring with optical coherence tomography (Conference Presentation)

Shih-Yang Chen, Yulu He, Cheng-Che Hsieh, Wei-Hsiang Hua, Meng Chun Low, Meng-Tsan Tsai, Yean-Woei Kiang, Chih-Chung Yang

Proceedings Volume 10078, 1007810 (2017) https://doi.org/10.1117/12.2249547

KEYWORDS: Gold, Optical coherence tomography, Continuous wave operation, Cancer, Surface plasmons, Photothermal effect, Oxygen, Femtosecond phenomena, Absorption, Optical scanning systems

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Proceedings Article | 18 April 2017 Paper

Contrast-enhanced optical coherence microangiography with acoustic-actuated microbubbles

Yu-Hsuan Liu, Jia-Wei Zhang, Chih-Kuang Yeh, Kuo-Chen Wei, Hao-Li Liu, Meng-Tsan Tsai

Proceedings Volume 10251, 102511F (2017) https://doi.org/10.1117/12.2269408

KEYWORDS: Coherence (optics), Optical coherence tomography, Ultrasonography, Angiography, Acoustics, Particles, Capillaries, Tissues, Biomedical optics, Image contrast enhancement

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Proceedings Article | 18 April 2017 Paper

Noninvasive imaging of oral mucosae with optical coherence tomography

Cheng-Yu Lee, Wei-Chuan Chen, Meng-Tsan Tsai

Proceedings Volume 10251, 102511E (2017) https://doi.org/10.1117/12.2269384

KEYWORDS: Optical coherence tomography, Angiography, Cancer, Imaging systems, In vivo imaging, Reflectivity, 3D image processing, Tissues, Visualization, 3D printing

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Proceedings Article | 18 April 2017 Paper

Study on laser-assisted drug delivery with optical coherence tomography

Wen-Guei Tsai, Ting-Yen Tsai, Chih-Hsun Yang, Meng-Tsan Tsai

Proceedings Volume 10251, 102510T (2017) https://doi.org/10.1117/12.2270936

KEYWORDS: Optical coherence tomography, Laser ablation, Gas lasers, Carbon monoxide, Diffusion, Liquids, In vivo imaging, Laser tissue interaction, Skin, Tissues

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Proceedings Article | 18 April 2017 Paper

Investigation of temporal effects on microcirculation induced by focused ultrasound

Yi-Xuan Liao, Hao-Li Liu, Meng-Tsan Tsai

Proceedings Volume 10251, 1025121 (2017) https://doi.org/10.1117/12.2273616

KEYWORDS: Skin, Algorithm development, Image processing, Speckle, Blood, Biomedical optics, Tissues, Acoustics, Ultrasonography, Microscopes

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Proceedings Article | 8 May 2014 Paper

A pseudo-spectrum reconstruction method for reducing saturation artifact in spectral-domain optical coherence tomography

Cheng-Kuang Lee, Meng-Tsan Tsai, Chiung-Ting Wu

Proceedings Volume 9129, 91290K (2014) https://doi.org/10.1117/12.2054721

KEYWORDS: Optical coherence tomography, Mirrors, Image processing, Fourier transforms, CCD cameras, Spectroscopy, Biomedical optics, Collimators, Roads, Objectives

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SPIE Journal Paper | 28 June 2013 Open Access

Quantitative observation of focused-ultrasound-induced vascular leakage and deformation via fluorescein angiography and optical coherence tomography

Meng-Tsan Tsai, Cheng-Kuang Lee, Kung-Min Lin, Yu-Xiang Lin, Tzu-Han Lin, Ting-Chia Chang, Jiann-Der Lee, Hao-Li Liu

JBO, Vol. 18, Issue 10, 101307, (June 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.10.101307

KEYWORDS: Optical coherence tomography, Blood vessels, Luminescence, Tissues, Ear, Imaging systems, Angiography, Ultrasonography, Acoustics, Fiber Bragg gratings

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SPIE Journal Paper | 1 September 2009 Open Access

Diagnosis of oral submucous fibrosis with optical coherence tomography

Cheng-Kuang Lee, Meng-Tsan Tsai, Hsiang-Chieh Lee, Hsin-Ming Chen, Chun-Ping Chiang, Yih-Ming Wang, Chih-Chung Yang

JBO, Vol. 14, Issue 05, 054008, (September 2009) https://doi.org/10.1117/12.10.1117/1.3233653

KEYWORDS: Optical coherence tomography, Collagen, Mouth, Tissues, Statistical analysis, Photomicroscopy, Photonics, Optoelectronics, Roads, Biopsy

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SPIE Journal Paper | 1 July 2009 Open Access

Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography

Meng-Tsan Tsai, Cheng-Kuang Lee, Hsiang-Chieh Lee, Hsin-Ming Chen, Chun-Ping Chiang, Yih-Ming Wang, Chih-Chung Yang

JBO, Vol. 14, Issue 04, 044028, (July 2009) https://doi.org/10.1117/12.10.1117/1.3200936

KEYWORDS: Optical coherence tomography, Cancer, Solids, Roads, Absorption, Photonics, Optoelectronics, Tissues, Optical scanning systems, Control systems

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SPIE Journal Paper | 1 July 2008 Open Access

Delineation of an oral cancer lesion with swept-source optical coherence tomography

Meng-Tsan Tsai, Hsiang-Chieh Lee, Chih-Wei Lu, Yih-Ming Wang, Cheng-Kuan Lee, Chi-Chung Yang, Chun-Ping Chiang

JBO, Vol. 13, Issue 04, 044012, (July 2008) https://doi.org/10.1117/12.10.1117/1.2960632

KEYWORDS: Optical coherence tomography, Cancer, Tissues, Imaging systems, Free space, Biopsy, Natural surfaces, Calibration, Biomedical optics, Signal detection

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SPIE Journal Paper | 1 November 2007 Open Access

Tissue birefringence of hypercholesterolemic rat liver measured with polarization-sensitive optical coherence tomography

Chau-Chung Wu, Yih-Ming Wang, Long-Sheng Lu, Chia-Wei Sun, Chih-Wei Lu, Meng-Tsan Tsai, Chih-Chung Yang

JBO, Vol. 12, Issue 06, 064022, (November 2007) https://doi.org/10.1117/12.10.1117/1.2812647

KEYWORDS: Liver, Birefringence, Tissue optics, Tissues, Optical coherence tomography, Collagen, Polarization, Beam splitters, Optical testing, In vitro testing

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SPIE Journal Paper | 1 September 2006 Open Access

Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser

Chia-Wei Sun, Yih-Ming Wang, Long-Sheng Lu, Chih-Wei Lu, I-Jen Hsu, Meng-Tsan Tsai, Chih-Chung Yang, Yean-Woei Kiang, Chau-Chung Wu

JBO, Vol. 11, Issue 05, 054016, (September 2006) https://doi.org/10.1117/12.10.1117/1.2363358

KEYWORDS: Polarization, Tissues, Heart, Optical coherence tomography, Birefringence, Tissue optics, Signal detection, Beam splitters, Light sources, Arteries

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Proceedings Article | 1 July 2004 Paper

Time-independent dispersion compensation in rapid-scanning optical coherence tomography

I-Jen Hsu, Chih-Wei Lu, Meng-Tsan Tsai, Chih Chung Yang

Proceedings Volume 5316, (2004) https://doi.org/10.1117/12.528561

KEYWORDS: Optical coherence tomography, Diffraction gratings, Prisms, Mirrors, Optical fibers, Lawrencium, Ray tracing, Numerical analysis, Light sources, Numerical simulations

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Showing 5 of 37 publications

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