The use of different 3D printing technologies for pharmaceutical manufacturing provides new opportunities for personalized medicine with adjusted doses in various shapes and structures. In this work, we present a novel manufacturing method of printing personalized dosage forms onto edible wafer papers as orodispersible thin films, targeting diseases such as types of cancer. Orodispersible films (ODFs) hold promise as a novel drug delivery method as they are easy to administer to young and older patients, bypass absorption by the digestive system and minimize the risk of partial loss of actives due to table crashing or imprecise liquid administration. LIFT technology could be used to “print” paclitaxel molecules on various surfaces that could be used as depot formulations. Laser-Induced Forward Transfer (LIFT) has been successfully applied in the nanosecond regime for the controlled transfer of paclitaxel solution onto the receiving substrates. Quantification studies of printed paclitaxel amount were determined by means of a Mass Spectrometry (MS)-based analytical technique. Furthermore, initial studies were performed where the printed paclitaxel wafer papers were used as orodispersible films (ODFs) on mice for oral mucosal drug delivery application, revealing encouraging results.
The use of different 3D printing technologies for pharmaceutical manufacturing provides new opportunities for personalized medicine and on-demand tailored drug products.In this work we present our recent achievements in developing a viable manufacturing process for printed personalized dosage forms of liquid-phase active substances (i.e. paclitaxel) in the nanosecond regime and the optimization of the printing process onto glass slide substrates via the Laser Induced Forward Transfer technique (LIFT). In the context of investigating the effectiveness of LIFT printing, the active pharmaceutical ingredient (API) quantification of the LIFT-printed paclitaxel films was confirmed using High-Performance Liquid Chromatography tandem Mass Spectrometry (HPLC-MS/MS) analysis.Initial experiments of APIs laser printing have shown good feasibility of this technique, highlighting LIFT as a promising method for pharmaceutical applications.
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