Dr. Jean-Luc Ravanat Profile

Dr. Jean-Luc Ravanat

at CEA-INAC

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 14 August 2019 Presentation

Radioluminescent nanomaterials to induce deep-tissue PDT: towards a complete description of the therapeutic contributions (Conference Presentation)

Anne-Laure Bulin, Frédéric Chaput, Mans Broekgaarden, Lucie Sancey, Jean-Luc Ravanat, Tayyaba Hasan, Hélène Elleaume

Proceedings Volume 11070, 110705F (2019) https://doi.org/10.1117/12.2525832

KEYWORDS: Photodynamic therapy, Nanomaterials, Radiotherapy, Tissue optics, Radiation effects, 3D modeling, Radio optics, X-rays, Synchrotron radiation, Tissues

Read Abstract +

Photodynamic therapy (PDT) is intrinsically restricted by the low penetration depth of light in tissue and is therefore mostly used to treat superficial or optical-fiber accessible lesions. An elegant non-invasive approach to overcome this limitation is to conjugate the photosensitizers to radioluminescent nanomaterials, also called nanoscintillators, and to activate these with radiation therapy. Upon X-ray irradiation, nanoscintillators are “switched on” and emit light that can subsequently excite the photosensitizer and induce PDT. As X-rays penetrate deeply in tissues, radioluminescence can activate PDT non-invasively at depth and without being restricted by large tumor volumes and optical shielding by blood vessels. The feasibility of exciting photosensitizers using nanoscintillators has been demonstrated, but the effects of this complex concept may stem from several therapeutic contributions that remain under-investigated. In this presentation, we report on the investigation of two confirmed contributions: 1) a potential synergy between low dose PDT and radiation therapy, and 2) a radiation dose enhancement effect stemming from increased radiation absorption by nanoscintillators composed of high-Z elements. The combination between low dose PDT and radiation therapy was assessed on heterocellular spheroid models of pancreatic cancer. The ability of nanoscintillators to induce radiation dose enhancement was experimentally assessed on 3D models of glioma, using synchrotron radiation to deliver radiation therapy. For this research, synchrotron radiation offers the unique opportunity to monochromatize the beam and tune its energy to an optimal value.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years