Dr. Hans-Peter F. Brecht Profile

Dr. Hans-Peter F. Brecht

COO at PhotoSound Technologies, Inc.

SPIE Involvement:

Author

Publications (32)

Proceedings Article | 12 March 2024 Presentation + Paper

Presentation + Paper

High-throughput photoacoustic tomography by integrated robotics and automation

Nathanael Marshall, Hans-Peter Brecht, Weylan Thompson, Dylan Lawrence, Vanessa Marshall, Samuel Toler, Stanislav Emelianov, Anthony Yu, Mark Anastasio, Umberto Villa, Joshua Maxwell, Sergey Ermilov

Proceedings Volume 12842, 128420I (2024) https://doi.org/10.1117/12.3005569

KEYWORDS: Imaging systems, Animals, Photoacoustic spectroscopy, Control systems, Spatial resolution, Animal model studies, Robotics, Acquisition tracking and pointing, Automation, Laser safety

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SPIE Journal Paper | 7 March 2023 Open Access

Open Access

Characterizing a photoacoustic and fluorescence imaging platform for preclinical murine longitudinal studies

Weylan R. Thompson, Hans-Peter F. Brecht, Vassili Ivanov, Anthony M. Yu, Diego S. Dumani, Dylan J. Lawrence, Stanislav Y. Emelianov, Sergey A. Ermilov

JBO, Vol. 28, Issue 03, 036001, (March 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.3.036001

KEYWORDS: Spatial resolution, Imaging systems, Photoacoustic spectroscopy, In vivo imaging, Acquisition tracking and pointing, Fluorescence imaging, Vacuum chambers, Biological imaging, Cameras, Reconstruction algorithms

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Proceedings Article | 3 March 2022 Presentation + Paper

Presentation + Paper

A combined ultrasound and photoacoustic imaging platform for clinical research applications

Weylan Thompson, Hans-Peter Brecht, Sergey Ermilov, Vassili Ivanov

Proceedings Volume 11960, 119600K (2022) https://doi.org/10.1117/12.2610099

KEYWORDS: Spatial resolution, Imaging systems, Ultrasonography, Photoacoustic imaging, In vivo imaging, Signal detection, Video, Functional imaging, Doppler effect, Data acquisition

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Proceedings Article | 17 February 2020 Paper

Paper

Massive parallel ultrasound and photoacoustic PC-based system

Weylan Thompson, Hans Peter Brecht, Sergey Ermilov, Vassili Ivanov

Proceedings Volume 11240, 112404H (2020) https://doi.org/10.1117/12.2547377

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Interfaces, Field programmable gate arrays, Data acquisition, Connectors, Visualization, Phased arrays

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Proceedings Article | 19 March 2019 Paper

Paper

Preclinical small animal imaging platform providing co-registered 3D maps of photoacoustic response and fluorescence

Diego Dumani, Anthony Yu, Weylan Thompson, Hans-Peter Brecht, Vassili Ivanov, Mark Anastasio, Jason Cook, Sergey Ermilov, Stanislav Emelianov

Proceedings Volume 10878, 108784Y (2019) https://doi.org/10.1117/12.2514489

KEYWORDS: Skin, Luminescence, Photoacoustic spectroscopy, Tissues, 3D image processing, Animal model studies, Preclinical imaging, Spatial resolution, In vivo imaging, Acquisition tracking and pointing

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Proceedings Article | 27 February 2019 Paper

Paper

Real-time photoacoustic data acquisition with a thousand parallel channels at hundreds frames per second

Vassili Ivanov, Hans Brecht, Sergey Ermilov

Proceedings Volume 10878, 108784Z (2019) https://doi.org/10.1117/12.2514488

KEYWORDS: Data acquisition, Clocks, Capacitance, Interfaces, Electromagnetic coupling, Amplifiers, Connectors, Field effect transistors, Signal to noise ratio, Human-machine interfaces

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Proceedings Article | 16 March 2018 Presentation + Paper

Presentation + Paper

A 3D imaging system integrating photoacoustic and fluorescence orthogonal projections for anatomical, functional and molecular assessment of rodent models

Hans P. Brecht, Vassili Ivanov, Diego Dumani, Stanislav Emelianov, Mark Anastasio, Sergey Ermilov

Proceedings Volume 10494, 1049411 (2018) https://doi.org/10.1117/12.2290880

KEYWORDS: Imaging systems, Tissue optics, 3D image processing, In vivo imaging, Image resolution, Data acquisition

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Proceedings Article | 28 February 2018 Presentation + Paper

Presentation + Paper

Co-registered photoacoustic and fluorescent imaging of a switchable nanoprobe based on J-aggregates of indocyanine green

Diego Dumani, Hans-Peter Brecht, Vassili Ivanov, Ryan Deschner, Justin Harris, Kimberly Homan, Jason Cook, Stanislav Emelianov, Sergey Ermilov

Proceedings Volume 10494, 104942W (2018) https://doi.org/10.1117/12.2291262

KEYWORDS: Nanoprobes, Luminescence, Photoacoustic spectroscopy, Molecular imaging, Photoacoustic imaging, Indocyanine green, Preclinical imaging, 3D image processing, Photoacoustic tomography, Cancer

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Proceedings Article | 29 March 2016 Paper

Paper

Advanced laser system for 3D optoacoustic tomography of the breast

Marc Klosner, Gary Chan, Chunbai Wu, Donald Heller, Richard Su, Sergey Ermilov, Hans Peter Brecht, Vassili Ivanov, Pratik Talole, Yang Lou, Mark Anastasio, Alexander Oraevsky

Proceedings Volume 9708, 97085B (2016) https://doi.org/10.1117/12.2209398

KEYWORDS: Breast, Laser systems engineering, Absorption, Imaging systems, Pulsed laser operation, Alexandrite lasers, Tissues, Blood, Breast imaging, Optical parametric oscillators

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Proceedings Article | 15 June 2011 Paper

Paper

Optoacoustic tomography in preclinical research: in vivo distribution of highly purified PEG-coated gold nanorods

Richard Su, Anton Liopo, Hans-Peter Brecht, Sergey Ermilov, Kirill Larin, Alexander Oraevsky

Proceedings Volume 8089, 808902 (2011) https://doi.org/10.1117/12.889757

KEYWORDS: Liver, Gold, Absorption, Toxicity, Tomography, In vivo imaging, 3D image processing, Tissues, Kidney, Nanorods

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Proceedings Article | 11 April 2011 Paper

Paper

Image processing and analysis in a dual-modality optoacoustic/ultrasonic system for breast cancer diagnosis

Vyacheslav Nadvoretskiy, Sergey Ermilov, Hans-Peter Brecht, Richard Su, Alexander Oraevsky

Proceedings Volume 7899, 789909 (2011) https://doi.org/10.1117/12.877389

KEYWORDS: Tumors, Image analysis, Image filtering, Imaging systems, Breast, Image processing, Breast cancer, Image enhancement, Tissues, Ultrasonography

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Proceedings Article | 11 April 2011 Paper

Paper

Optoacoustic imaging system with improved collection efficiency

Dmitri Tsyboulski, André Conjusteau, Sergey Ermilov, Hans-Peter Brecht, Anton Liopo, Richard Su, Vyacheslav Nadvoretsky, Alexander Oraevsky

Proceedings Volume 7899, 78991D (2011) https://doi.org/10.1117/12.877723

KEYWORDS: Transducers, Ultrasonography, Wavefronts, Microscopy, Reflectors, Mirrors, Acoustics, Signal attenuation, Imaging systems, Spherical lenses

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Proceedings Article | 28 February 2011 Paper

Paper

Gold nanorod distribution in mouse tissues after intravenous injection monitored with optoacoustic tomography

Richard Su, Anton Liopo, Hans-Peter Brecht, Sergey Ermilov, Alexander Oraevsky

Proceedings Volume 7899, 78994B (2011) https://doi.org/10.1117/12.878794

KEYWORDS: Liver, Kidney, Gold, Spleen, Tissues, Nanoparticles, Tomography, In vivo imaging, Silver, Nanorods

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SPIE Journal Paper | 1 March 2010 Open Access

Open Access

Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature

Matthew Fronheiser, Sergey Ermilov, Hans-Peter Brecht, André Conjusteau, Richard Su, Ketan Mehta, Alexander Oraevsky

JBO, Vol. 15, Issue 02, 021305, (March 2010) https://doi.org/10.1117/12.10.1117/1.3370336

KEYWORDS: Arteries, Veins, Blood vessels, Visualization, Imaging systems, Video, Ultrasonography, Real time imaging, Skin, Blood circulation

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SPIE Journal Paper | 1 March 2010 Open Access

Open Access

Optoacoustic imaging of the prostate: development toward image-guided biopsy

Mohammad Yaseen, Sergey Ermilov, Hans-Peter Brecht, Richard Su, André Conjusteau, Matthew Fronheiser, Brent Bell, Massoud Motamedi, Alexander Oraevsky

JBO, Vol. 15, Issue 02, 021310, (March 2010) https://doi.org/10.1117/12.10.1117/1.3333548

KEYWORDS: Prostate, Tissues, Acoustics, Tissue optics, Signal detection, Biopsy, In vivo imaging, Imaging systems, Tumors, Signal processing

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SPIE Journal Paper | 1 March 2010 Open Access

Open Access

Feasibility of optoacoustic visualization of high-intensity focused ultrasound-induced thermal lesions in live tissue

Parag Chitnis, Hans-Peter Brecht, Richard Su, Alexander Oraevsky

JBO, Vol. 15, Issue 02, 021313, (March 2010) https://doi.org/10.1117/12.10.1117/1.3339977

KEYWORDS: Tissue optics, Tissues, Transducers, Absorption, In vivo imaging, Visualization, Thermography, Imaging systems, Ultrasonography, Blood

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Proceedings Article | 26 February 2010 Paper

Paper

In vivo 3D visualization of peripheral circulatory system using linear optoacoustic array

Sergey Ermilov, Hans-Peter Brecht, Matthew Fronheiser, Vyacheslav Nadvoretsky, Richard Su, Andre Conjusteau, Alexander Oraevsky

Proceedings Volume 7564, 756422 (2010) https://doi.org/10.1117/12.847933

KEYWORDS: Blood vessels, Arteries, Computer simulations, Veins, Absorption, Skin, 3D image processing, Blood, In vivo imaging, Laser beam diagnostics

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Proceedings Article | 24 February 2010 Paper

Paper

Toward functional imaging using the optoacoustic 3D whole-body tomography system

R. Su, H.-P. Brecht, S. Ermilov, V. Nadvoretsky, A. Conjusteau, A. Oraevsky

Proceedings Volume 7564, 756423 (2010) https://doi.org/10.1117/12.847044

KEYWORDS: Absorption, Nickel, Tomography, Imaging systems, 3D image processing, Scattering, Signal processing, Wavelets, Functional imaging, Filtering (signal processing)

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Proceedings Article | 24 February 2010 Paper

Paper

Optoacoustic imaging of HIFU-induced thermal lesions in tissue

Parag Chitnis, Hans-Peter Brecht, Richard Su, Alexander Oraevsky

Proceedings Volume 7564, 75643I (2010) https://doi.org/10.1117/12.847114

KEYWORDS: Tissues, Tissue optics, In vivo imaging, Absorption, Transducers, Ultrasonography, Tumors, Visualization, Blood, Liver

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Proceedings Article | 24 February 2010 Paper

Paper

Real-time optoacoustic imaging of breast cancer using an interleaved two laser imaging system coregistered with ultrasound

Sergey Ermilov, Matthew Fronheiser, Vyacheslav Nadvoretsky, Hans-Peter Brecht, Richard Su, André Conjusteau, Ketan Mehta, Pamela Otto, Alexander Oraevsky

Proceedings Volume 7564, 75641W (2010) https://doi.org/10.1117/12.847946

KEYWORDS: Tumors, Breast, Breast cancer, Ultrasonics, Imaging systems, Ultrasonography, Blood vessels, Mammography, Deconvolution, Visualization

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Proceedings Article | 24 February 2010 Paper

Paper

Compensation for transducer effects in optoacoustic tomography

Kun Wang, Mark Anastasio, Sergey Ermilov, Hans-Peter Brecht, Richard Su, Alexander Oraevsky

Proceedings Volume 7564, 75640P (2010) https://doi.org/10.1117/12.842459

KEYWORDS: Transducers, Reconstruction algorithms, Tomography, Image restoration, 3D modeling, Ultrasonography, Image resolution, Data modeling, Optical tomography, Optical imaging

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Proceedings Article | 24 February 2010 Paper

Paper

Effects of optical energy distribution on the generation of acoustic plane waves

André Conjusteau, Sergey Ermilov, Hans-Peter Brecht, Alexander Oraevsky

Proceedings Volume 7564, 75641L (2010) https://doi.org/10.1117/12.846992

KEYWORDS: Acoustics, Pulsed laser operation, Sensors, Transducers, Signal detection, Signal attenuation, Ultrasonics, Wavefronts, Laser energy, Absorption

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SPIE Journal Paper | 1 November 2009 Open Access

Open Access

Whole-body three-dimensional optoacoustic tomography system for small animals

Hans-Peter Brecht, Richard Su, Matthew Fronheiser, Sergey Ermilov, André Conjusteau, Alexander Oraevsky

JBO, Vol. 14, Issue 06, 064007, (November 2009) https://doi.org/10.1117/12.10.1117/1.3259361

KEYWORDS: Tomography, Transducers, 3D image processing, Imaging systems, Opacity, Visualization, Video, Veins, Tissue optics, Kidney

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Proceedings Article | 25 February 2009 Paper

Paper

Detection of gold-nanorod targeted pathogens using optical and piezoelectric optoacoustic sensors: comparative study

André Conjusteau, Saher Maswadi, Sergey Ermilov, Hans-Peter Brecht, Norman Barsalou, Randolph Glickman, Alexander Oraevsky

Proceedings Volume 7177, 71771P (2009) https://doi.org/10.1117/12.813434

KEYWORDS: Transducers, Acoustics, Sensors, Laser beam diagnostics, Gold, Signal detection, Signal generators, Target detection, Pathogens, Nanorods

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Proceedings Article | 25 February 2009 Paper

Paper

Characterization of optoacoustic transducers through the analysis of angular-dependent frequency response

André Conjusteau, Sergey Ermilov, Richard Su, Hans-Peter Brecht, Matthew Fronheiser, Alexander Oraevsky

Proceedings Volume 7177, 71770U (2009) https://doi.org/10.1117/12.812339

KEYWORDS: Transducers, Acoustics, Sensors, Calibration, Wavefronts, Ultrasonography, Signal attenuation, Pulsed laser operation, Image restoration, Signal to noise ratio

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Proceedings Article | 25 February 2009 Paper

Paper

Optoacoustic 3D whole-body tomography: experiments in nude mice

Hans-Peter Brecht, Richard Su, Matt Fronheiser, Sergey Ermilov, André Conjusteau, Anton Liopo, Massoud Motamedi, Alexander Oraevsky

Proceedings Volume 7177, 71770E (2009) https://doi.org/10.1117/12.812319

KEYWORDS: Blood vessels, Linear filtering, Wavelets, Tomography, Electronic filtering, Transducers, Imaging systems, Tissue optics, 3D image processing, Alexandrite lasers

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Proceedings Article | 25 February 2009 Paper

Paper

Development of laser optoacoustic and ultrasonic imaging system for breast cancer utilizing handheld array probes

Sergey Ermilov, Matthew Fronheiser, Hans-Peter Brecht, Richard Su, André Conjusteau, Ketan Mehta, Pamela Otto, Alexander Oraevsky

Proceedings Volume 7177, 717703 (2009) https://doi.org/10.1117/12.812192

KEYWORDS: Breast, Transducers, Tumors, Acoustics, Ultrasonics, Imaging systems, 3D modeling, Signal processing, Visualization, Tissue optics

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We describe two laser optoacoustic imaging systems for breast cancer detection based on arrays of acoustic detectors operated manually in a way similar to standard ultrasonic breast imaging. The systems have the advantages of standard light illumination (regardless of the interrogated part of the breast), the ability to visualize any part of the breast, and convenience in operation. The first system could work in both ultrasonic and optoacoustic mode, and was developed based on a linear ultrasonic breast imaging probe with two parallel rectangular optical bundles. We used it in a pilot clinical study to provide for the first time demonstration that the boundaries of the tumors visualized on the optoacoustic and ultrasonic images matched. Such correlation of coregistered images proves that the objects on both images represented indeed the same tumor. In the optoacoustic mode we were also able to visualize blood vessels located in the neighborhood of the tumor. The second system was proposed as a circular array of acoustic transducers with an axisymmetric laser beam in the center. It was capable of 3D optoacoustic imaging with minimized optoacoustic artifacts caused by the distribution of the absorbed optical energy within the breast tissue. The distribution of optical energy absorbed in the bulk tissue of the breast was removed from the image by implementing the principal component analysis on the measured signals. The computer models for optoacoustic imaging using these two handheld probes were developed. The models included three steps: (1) Monte Carlo simulations of the light distribution within the breast tissue, (2) generation of optoacoustic signals by convolving N-shaped pressure signals from spherical voxels with the shape of individual transducers, and (3) back-projecting processed optoacoustic signals onto spherical surfaces for image reconstruction. Using the developed models we demonstrated the importance of the included spatial impulse response of the optoacoustic imaging system.

Proceedings Article | 28 February 2008 Paper

Paper

Hybrid optoacoustic and ultrasonic imaging system for detection of prostate malignancies

Mohammad Yaseen, H. P.-F. Brecht, Sergey Ermilov, Reda Gharieb, Andre Conjusteau, Alexander Oraevsky

Proceedings Volume 6856, 68560T (2008) https://doi.org/10.1117/12.769881

KEYWORDS: Prostate, Tissues, Tumors, Signal detection, Ultrasonography, Transducers, Signal processing, Imaging systems, Ultrasonics, Absorption

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Proceedings Article | 12 March 2007 Paper

Paper

Optoacoustic imaging of blood vessels

I. Patrikeev, H. Brecht, Y. Petrov, I. Petrova, D. Prough, R. Esenaliev

Proceedings Volume 6513, 65130R (2007) https://doi.org/10.1117/12.711176

KEYWORDS: Blood vessels, Monte Carlo methods, Blood, Transducers, Ultrasonography, Veins, Absorption, Arteries, Visualization, Tissues

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Proceedings Article | 13 February 2007 Paper

Paper

Wavelet differentiation of optoacoustic signals for monitoring of total hemoglobin concentration and oxygen saturation level in small blood vessels

I. Patrikeev, H.-P. Brecht, Y. Petrov, I. Petrova, D. Prough, R. Esenaliev

Proceedings Volume 6437, 643717 (2007) https://doi.org/10.1117/12.714185

KEYWORDS: Signal to noise ratio, Wavelets, Blood vessels, Oxygen, Monte Carlo methods, Signal processing, Smoothing, Blood, Arteries, Skin

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Proceedings Article | 13 February 2007 Paper

Paper

Scanning system for noninvasive optoacoustic monitoring of blood oxygenation in the internal jugular vein

H.-P. Brecht, D. Prough, Y. Petrov, I. Patrikeev, R. Esenaliev

Proceedings Volume 6437, 643704 (2007) https://doi.org/10.1117/12.714129

KEYWORDS: Blood, Blood vessels, Veins, Signal processing, Traumatic brain injury, LabVIEW, Signal detection, Absorption, Optical properties, Hypoxia

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Proceedings Article | 10 May 2001 Paper

Paper

Dynamic tether force measurements of the outer hair cells plasma membrane with optical tweezers

Bahman Anvari, Zhiwei Li, Masayoshi Takashima, Peter Brecht, Jorge Torres, William Brownell

Proceedings Volume 4260, (2001) https://doi.org/10.1117/12.426765

KEYWORDS: Magnetism, Microscopes, Objectives, Calibration, Optical tweezers, Plasma, 3D image processing, Cytoskeletons, Transducers, Image resolution

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Showing 5 of 32 publications

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