Mr. Divyesh Sharma Profile

Divyesh Sharma

Research Assistant at USFDA

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 23 March 2005 Paper

Evaluation of a fiber-optic-based system for optical property measurement in highly attenuating turbid media

Thomas Pfefer, Divyesh Sharma, Anant Agrawal, L. Stephanie Matchette

Proceedings Volume 5691, (2005) https://doi.org/10.1117/12.591101

KEYWORDS: Optical properties, Reflectivity, Data modeling, Tissue optics, Calibration, Tissues, Fiber optics, Diffuse reflectance spectroscopy, Optical testing, Monte Carlo methods

Read Abstract +

Fluorescence- and reflectance-based imaging techniques have a strong potential to improve clinical detection of pathologies such as cervical neoplasia. However, quantitative understanding of data collected by these approaches necessitates information on tissue optical properties in vivo. At present, there is minimal in vivo data on the optical properties of many tissues in the wavelength range that is most relevant -- the ultraviolet A to visible. We report here on the development and evaluation of a second-generation diffuse reflectance system for measurement of tissue optical properties using a linear-array fiber optic probe with maximum separation distance of 2.5 mm. Improvements over the prior system include the implementation of an imaging spectrograph, a high sensitivity CCD camera and in-line neutral density filters to maximize dynamic range and signal to noise ratio. Absolute measurements of tissue reflectance were enabled through calibration of the reflectance system. Multivariate calibration models for optical property prediction were generated using a neural network algorithm and reflectance distributions calculated by a Monte Carlo model. Spatially-resolved reflectance data sets were measured in well--characterized tissue phantoms at 405 nm for absorption coefficients (μ_a) from 1 to 25 cm^-1 and reduced scattering coefficients (μ_s') from 5 to 25 cm^-1. These models were used to estimate the optical properties of tissue phantoms from reflectance measurements. By comparing predicted and known optical properties, the average percent error for μ_a and μ_s' was found to be ± 3.2% and ±5.6%, respectively. These results indicate a level of accuracy that is more than twice that of our prior approach.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years