Dr. Diego Pugliese Profile

Dr. Diego Pugliese

at Politecnico di Torino

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Author

Publications (18)

Proceedings Article | 13 March 2024 Presentation

Bioresorbable multifunctional fiber-optic devices for theranostic and monitoring of tumor

Jawad Pandayil, Nadia Boetti, Lorenzo Cortese, Vamshi Damagatla, Davide Janner, Turgut Durduran, Antonio Pifferi, Diego Pugliese

Proceedings Volume PC12835, PC1283503 (2024) https://doi.org/10.1117/12.3002672

KEYWORDS: Fiber optics, Tumors, Tissues, Photodynamic therapy, Phosphates, Optical fibers, Calcium, Biomedical applications, Surgery, Spectroscopes

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Proceedings Article | 8 September 2023 Paper

Use of bioresorbable fibers for interstitial time-domain diffuse optical spectroscopy with fast-gating

Vamshi Damagatla, Nadia Boetti, Laura Di Sieno, Diego Pugliese, Davide Janner, Alberto Dalla Mora, Antonio Pifferi

Proceedings Volume 12628, 1262818 (2023) https://doi.org/10.1117/12.2670504

KEYWORDS: Absorption, Diffuse optical spectroscopy, Single photon avalanche diodes, Scattering, Liquids, Tissues, Optical fibers, Light scattering, Glasses, Water

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Proceedings Article | 11 August 2023 Paper

Towards a novel bi-functional bioresorbable micro-structured optical fiber for theranostic applications

Jawad Pandayil, Seyed Mussavi Rizi, Sharon Russo, Nadia Giovanna Boetti, Diego Pugliese, Davide Janner

Proceedings Volume 12627, 126271N (2023) https://doi.org/10.1117/12.2670867

KEYWORDS: Optical fibers, Phosphates, Multicore fiber, Glasses, Biomedical applications, Structured optical fibers, Biomedical optics, Thermography, Optical transmission, Optical properties

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Proceedings Article | 30 May 2023 Presentation

Dy3+-doped phosphate glass optical fibers for 577 nm wavelength fiber lasers (Conference Presentation)

Diego Pugliese, Martha Segura, Nadia Giovanna Boetti, Joris Lousteau, Guido Perrone, Davide Janner, Sami Slimi, Pavel Loiko, Mailyn Ceballos, Xavier Mateos

Proceedings Volume 12573, 125730A (2023) https://doi.org/10.1117/12.2665269

KEYWORDS: Glasses, Phosphates, Optical fibers, Fiber lasers, Lasers, Diodes, Visualization, Visible radiation, Semiconductor lasers, Second-harmonic generation

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Proceedings Article | 6 March 2023 Presentation + Paper

Toward the development of direct emission yellow fiber lasers for biomedical applications

Valentina Serafini, Diego Pugliese, Aurora Bellone, Joris Lousteau, F. Khozeymeh Sarbishe, Federica Poli, Annamaria Cucinotta, Guido Perrone

Proceedings Volume 12372, 1237202 (2023) https://doi.org/10.1117/12.2650702

KEYWORDS: Fiber lasers, Glasses, Phosphates, Dysprosium, Laser development

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Proceedings Article | 25 May 2022 Presentation

High concentration Er-doped phosphate glass optical fibers for single-frequency fiber amplifiers

Nadia Giovanna Boetti, Phillip Booker, Diego Pugliese, Joris Lousteau, Alberto Rovera, Peter Wessels, Jörg Neumann, D. Kracht, Davide Janner, Daniel Milanese

Proceedings Volume PC12140, PC1214002 (2022) https://doi.org/10.1117/12.2624407

KEYWORDS: Glasses, Fiber amplifiers, Optical fibers, Ions, Silica, Fiber lasers, Cladding, Semiconductor lasers, Optics manufacturing, Laser sources

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The continuous improvement of interferometric gravitational-wave detectors (GWDs) and the preparations for next generation of GWDs set highly demanding requirements on their laser sources. A promising candidate to fulfill the challenging requirements of GWD laser sources is the hybrid master-oscillator power fiber amplifier (MOPFA) configuration. The implementation of a MOPFA relies principally on commercial silica glass-based optical fiber technology, which has been key in the successful development of high-power fiber amplifiers but that poses also a limitation to power scaling of these devices. It is well known that erbium (Er) ions tend to cluster in silica glass leading to ion-ion interactions and degradation of performance. The limited concentration of RE ions per unit length implies a limited optical gain per unit length and thus the requirement for long amplifying fiber lengths that enforce deleterious nonlinear effects, foremost stimulated Brillouin scattering (SBS). Numerous SBS suppression techniques have been proposed, alongside investigation of specialty optical fibers. One of the most promising solutions is the use of highly doped optical fibers based on multicomponent phosphate glass that allows the fabrication of ultra-compact active devices with minimized nonlinearities. To realize compact optical fiber amplifiers operating at 1.5 µm, a series of highly Er3+-doped custom phosphate glass compositions was designed and fabricated to be used as active materials for the core of the fiber amplifiers. Suitable cladding compositions were explored. Core and cladding glasses were synthesized by melt-quenching method. The core glass was cast into a cylindrical mold to form a rod, whereas the cladding tube was fabricated by extrusion technique. Phosphate fibers were then manufactured by drawing the preform assembled by rod-in-tube technique. Preliminary results of the application of the Er3+-doped phosphate fiber as laser active medium in a fully monolithic single-mode single-frequency core-pumped MOPFA setup resonantly pumped at around 1480 nm are presented.

Proceedings Article | 18 April 2021 Presentation

Highly doped multicomponent phosphate glass fibers for compact pulsed optical amplifiers

Nadia Giovanna Boetti, Diego Pugliese, Omri Moschovits, Enkeleda Balliu, Joris Lousteau, Duccio Gallichi-Nottiani, Davide Janner, Amiel Ishaaya, Magnus Engholm, Daniel Milanese

Proceedings Volume 11773, 117730N (2021) https://doi.org/10.1117/12.2590840

KEYWORDS: Glasses, Optical fibers, Optical amplifiers, Fiber amplifiers, Cladding, Oscillators, Optics manufacturing, LIDAR, Ions, Fiber lasers

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Proceedings Article | 1 April 2020 Presentation

Bioresorbable phosphate glass microstructured optical fiber for simultaneous light and drug delivery (Conference Presentation)

Diego Pugliese, Duccio Gallichi-Nottiani, Nadia Giovanna Boetti, Ondrej Podrazký, Pavel Peterka, Daniel Milanese, Davide Luca Janner

Proceedings Volume 11355, 113550J (2020) https://doi.org/10.1117/12.2556479

KEYWORDS: Optical fibers, Glasses, Structured optical fibers, In vivo imaging, Biomedical optics, Diagnostics, Capillaries, Optical properties, In vitro testing, Fabrication

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Proceedings Article | 1 April 2020 Presentation

Toward the fabrication of directly extruded microstructured bioresorbable phosphate glass optical fibre preforms (Conference Presentation)

Duccio Gallichi-Nottiani, Diego Pugliese, Nadia Boetti, Daniel Milanese, Davide Janner

Proceedings Volume 11357, 113571N (2020) https://doi.org/10.1117/12.2556381

KEYWORDS: Glasses, Optical fibers, Fabrication, Transmittance, Shape analysis, Photonic crystal fibers, Fiber optics sensors, Sensors, Optical properties, Silica

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Proceedings Article | 1 April 2020 Presentation

A SERS affinity bioassay based on ion-exchanged glass microrods (Conference Presentation)

Simone Berneschi, Cristiano D'Andrea, Ambra Giannetti, Marella De Angelis, Martina Banchelli, Andrea Barucci, Nadia Giovanna Boetti, Stefano Pelli, Francesco Baldini, Roberto Pini, Davide Janner, Diego Pugliese, Daniel Milanese, Paolo Matteini

Proceedings Volume 11361, 113610V (2020) https://doi.org/10.1117/12.2555817

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The well-known enhancement effect of surface-enhanced Raman spectroscopy (SERS) is associated with the presence of metallic nanostructures at the substrate surface. Different bottom-up and top-down processes have been proposed to impart the substrate with such a nanostructured layer. The former approaches are low cost but may suffer from reusability and stability. The latter strategies are expensive, time consuming and require special equipment that complicate the fabrication process. Here, we present the possibility to obtain stable and reusable SERS substrates by a low-cost silver-sodium ion-exchange process in soda-lime glass microrods. The microrods were obtained by cutting the tip of the ion-exchanged soda-lime fiber, resulting in disks of about few millimeters in length and one hundred microns in diameter. A thermal annealing post-process was applied to trigger the reduction of Ag+ ions into nanoparticles (AgNPs) within the ion-exchanged glass microrods. Afterwards, ion-exchange and thermal treatments were carefully tuned to assure the presence of silver NPs exposed on the surface of the microrods, without using any chemical etching. An AFM analysis confirmed the presence of AgNPs with size of tens of nm on the surface of the fiber probe. A SERS affinity bioassay was developed on the probe with the final aim of detecting microRNA fragments acting as biomarkers of different diseases. Specifically a DNA hybridization assay was built up by anchoring a molecular beacon containing a Raman tag on the Ag surface via thiol chemistry. Initial SERS experiments confirmed the presence of the beacon on the NPs embedded on the microrods surface, as monitored by detecting main spectral bands ascribed to the oligonucleotide chain. Finally, the ability of the platform to interact with the target microRNA sequence was assessed. The analysis was repeated on a number of miRNA sequences differing from the target to evaluate the specificity of the proposed assay.

Proceedings Article | 22 July 2019 Paper

Multimaterial bioresorbable optical fibers for theranostics

Daniel Milanese, Diego Pugliese, Nadia Boetti, Stavros Pissadakis, Maria Konstantaki, Pavel Peterka, Laura Di Sieno, Duccio Gallichi-Nottiani, Joris Lousteau, Davide Janner

Proceedings Volume 11075, 110750S (2019) https://doi.org/10.1117/12.2527679

KEYWORDS: Optical fibers, Glasses, Fiber Bragg gratings, Sensors, Diffuse optical imaging, Biomedical optics, Breast, Single mode fibers, Temperature sensors, Oxides

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Proceedings Article | 16 April 2019 Paper

High-power laser tests of phosphate glass-based bioresorbable optical fibers transmission

Pavel Peterka, Michael Písařík, Hana Turčičová, Jitka Černohorská, Ondřej Podrazký, Pavel Honzátko, Petr Vařák, Diego Pugliese, Nadia Boetti, Duccio Gallichi-Nottiani, Davide Janner, Daniel Milanese

Proceedings Volume 11029, 1102911 (2019) https://doi.org/10.1117/12.2523188

KEYWORDS: Optical fibers, Fiber lasers, Continuous wave operation, High power lasers, Silica, Sensors, Pulsed laser operation, Optical testing, Structured optical fibers

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Proceedings Article | 5 March 2019 Presentation

Yb/Er phosphate optical glasses and fibers for eye-safe compact optical amplifiers in LIDARs (Conference Presentation)

Nadia Boetti, Diego Pugliese, Duccio Gallichi Nottiani, Davide Janner, Federico Leone, Gabriele Coppola, Gabriele Tombesi, Chiara Novara, Daniel Milanese

Proceedings Volume 10914, 1091414 (2019) https://doi.org/10.1117/12.2509892

KEYWORDS: Glasses, Optical amplifiers, LIDAR, Optical fibers, Waveguides, Cladding, Environmental monitoring, Surveillance, Ions, Nonlinear optics

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Proceedings Article | 1 March 2019 Presentation + Paper

Bioresorbable fibers for time-domain diffuse optical measurements: a step toward next generation optical implantable devices

Laura Di Sieno, Nadia Boetti, Alberto Dalla Mora, Diego Pugliese, Andrea Farina, Sanathana Konugolu Venkata Sekar, Edoardo Ceci-Ginistrelli, Davide Janner, Antonio Pifferi, Daniel Milanese

Proceedings Volume 10874, 1087409 (2019) https://doi.org/10.1117/12.2509501

KEYWORDS: Optical fibers, Photons, Scattering, Absorption, Sensors, Tissues, Breast, Optical testing, Signal attenuation, Optical properties

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Proceedings Article | 23 May 2018 Presentation

Resorbable phosphate glass optical and hollow fibers for biomedicine (Conference Presentation)

Daniel Milanese, Edoardo Ceci-Ginistrelli, Diego Pugliese, Nadia Boetti, Cecilia Bertiond, Mauro Tortello, Vincenzo Sglavo, Nadia Barbero, Sonja Visentin, Duccio Gallichi-Nottiani, Claudia Barolo, Davide Janner

Proceedings Volume 10681, 106810R (2018) https://doi.org/10.1117/12.2316417

KEYWORDS: Optical fibers, Glasses, Biomedical optics, Tissue optics, Photodynamic therapy, Tissues, Silicates, Optical engineering, Transparency, Cladding

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Optical fibers have been employed for several years in biomedicine and mainly used for light delivery and collection with high efficiency and selectivity. So far most of the research effort has been devoted to the optical configurations and the functions of the fibers rather than on the materials employed. Indeed, this aspect has been mainly considered to assure biocompatibility with tissues and non-toxic behavior limiting the choice mostly to silicate fibers. We report on the recent advances in engineering inorganic glass optical and hollow fibers fabricated with optical glasses which are also resorbable in body fluids. Suitable phosphate glass compositions were designed to combine resorbability and optical transparency. Glasses were fabricated by melt-quenching inside a chamber furnace under a flux of dried air and cast into preheated brass molds. The fibers were obtained by preform drawing, with the core rod fabricated by melt quenching whilst the cladding tube by rotational casting. Extrusion techniques were also applied to obtain more complex cross sections with increased functionalities. Glasses and fibers were characterized in their physical and optical properties. The materials showed high stability toward crystallization and a wide optical transmission window, ranging from the ultraviolet to the near infrared wavelength regions. Hollow fibers were employed to demonstrate multifunctional fiber probes, able to provide drug delivery and light excitation in the prospect of developing resorbable endoscopes for intravital monitoring and therapy, such as photodynamic therapy. Optimization of drug delivery was carried out using functionalization procedures on the surface of both bulk glasses and hollow fibers, aiming to modify the release kinetics: a silanization protocol was developed and successfully tested using different organic compounds. The modification of the surface roughness was monitored using atomic force microscopy, while surface energy changes verified using contact angle measurements. The possibility of performing drug excitation was assessed by guiding light through the capillary using optical beams produced by different wavelength sources covering the visible spectrum. Finally, mechanical characterization of the prepared optical fibers and hollow fibers was carried out to measure the elastic moduli, the tensile strength and the minimum radius of curvature attainable. The overall results allowed to demonstrate the reliability of the proposed optical fibers and hollow fibers for biomedical applications.

Proceedings Article | 13 February 2018 Presentation + Paper

Biomedical and sensing applications of a multi-mode biodegradable phosphate-based optical fiber

Ondřej Podrazky, Pavel Peterka, Soňa Vytykáčová, Jana Proboštová, Martin Kuneš, Oleksiy Lyutakov, Edoardo Ceci-Ginistrelli, Diego Pugliese, Nadia Boetti, Davide Janner, Daniel Milanese

Proceedings Volume 10488, 104880H (2018) https://doi.org/10.1117/12.2285148

KEYWORDS: Optical fibers, Glasses, In vivo imaging, Silica, Tissues, Biomedical optics, In vitro testing, Sensors, Blood, Biosensing

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Proceedings Article | 28 July 2017 Paper

Hollow resorbable fiber for combined light and drug delivery: fiber development and analysis of release kinetics

Edoardo Ceci-Ginistrelli, Cecilia Bertiond, Davide Janner, Diego Pugliese, Nadia Barbero, Nadia Boetti, Sonja Visentin, Claudia Barolo, Daniel Milanese

Proceedings Volume 10413, 104130G (2017) https://doi.org/10.1117/12.2284313

KEYWORDS: Photodynamic therapy

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Proceedings Article | 28 July 2017 Paper

Time-domain diffuse optics using bioresorbable fibers: a proof-of-principle study

Laura Di Sieno, Nadia Boetti, Alberto Dalla Mora, Diego Pugliese, Andrea Farina, Sanathana Konugolu Venkata Sekar, Edoardo Ceci-Ginistrelli, Davide Janner, Antonio Pifferi, Daniel Milanese

Proceedings Volume 10413, 104130E (2017) https://doi.org/10.1117/12.2290147

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