Dr. David O. Otuya Profile

Dr. David O. Otuya

Research Fellow at Massachusetts General Hospital

SPIE Involvement:

Author | Career Lab Leader

Publications (16)

Proceedings Article | 17 March 2023 Presentation

Presentation

A portable and minimally invasive human nasal potential difference (NPD) measurement system

David Otuya, Kadambari Vijaykumar, Sophia Zoghbi, Nicolas Dechene, Emily Ryan, Sarah Silva, Heather Harthone, Catriona Grant, Steven Rowe, Marty Solomon, Guillermo Tearney

Proceedings Volume PC12356, PC1235604 (2023) https://doi.org/10.1117/12.2650620

KEYWORDS: Electrodes, Optical coherence tomography, Modulation, Ion channels, Cystic fibrosis, Bridges, Visualization, Tolerancing, Resistance, Proteins

Read Abstract +

Proceedings Article | 17 March 2023 Presentation

Presentation

A minimally invasive tethered capsule endomicroscopy and biopsy platform

Andrew Thrapp, Rachel Shore, Tyler Rhim, David Otuya, Tara Lignelli, Matt Beatty, Rachel Smith, Gary Tearney

Proceedings Volume PC12356, PC123560I (2023) https://doi.org/10.1117/12.2650048

KEYWORDS: Biopsy, Tissues, Optical coherence tomography, Endomicroscopy, In vivo imaging, Cancer, Esophagus, Video, Target acquisition, Statistical analysis

Read Abstract +

Proceedings Article | 17 March 2023 Presentation

Presentation

Unsedated transnasal optical coherence tomography imaging in healthy pregnant women

Evangelia Gavgiotakis, David Otuya, Rachel Shore, Alissa Cirio, Tyler Rihm, Alexander Krall, Peter Choy, Sarah Giddings, Anita Chung, Catriona Grant, Paola Leon Alarcon, Ara Bablouzian, Matthew Beatty, Guillermo Tearney

Proceedings Volume PC12356, PC1235606 (2023) https://doi.org/10.1117/12.2652751

KEYWORDS: Optical coherence tomography, Coherence imaging, Optical imaging, Visualization, Stomach, Esophagus, Tissues, Safety, Polyurethane, Nose

Read Abstract +

Proceedings Article | 9 March 2023 Presentation

Presentation

Self-propelled retrograde tethered capsule endomicroscopy (R-TCE) in the colon

Du-Ri Song, Tara Lignelli, Mikayla Tinus, Evan Sevieri, Patricia Grahmann, John McDaniel, Alissa Cirio, Paola Alarcon, Seamus Winters, Hamed Khalili, Abigail Gregg, David Otuya, Jing Dong, Adam Mauskapf, Joseph Gardecki, Andrew Thrapp, Guillermo Tearney

Proceedings Volume PC12367, PC1236702 (2023) https://doi.org/10.1117/12.2652740

KEYWORDS: Colon, Endomicroscopy, Optical coherence tomography, Imaging devices, Image segmentation, 3D image processing, X-rays, X-ray imaging, Visualization, Stereoscopy

Read Abstract +

Proceedings Article | 7 March 2022 Presentation

Presentation

3D printed micro-optics for astigmatism correction in catheter-based endoscopic imaging

Evangelia Gavgiotaki, Radhika Poduval, David Otuya, Alissa Cirio, Shoumik Lodh, Tyler Rihm, Rachel Shore, Peter Choy, Sarah Silva, Alexander Krall, Paola Leon Alarcon, Patricia Grahmann, Osman Ahsen, Guillermo Tearney

Proceedings Volume PC11937, PC1193701 (2022) https://doi.org/10.1117/12.2607309

KEYWORDS: Monochromatic aberrations, Micro optics, Optical coherence tomography, Endoscopy, 3D image processing, Stereoscopy, Lenses, Image quality standards, Zemax, Optics manufacturing

Read Abstract +

Proceedings Article | 7 March 2022 Presentation

Presentation

Safety study of tethered capsule endomicroscopy (TCE) pull back through long segments of the small intestine

Du-Ri Song, Mikayla Tinus, Patricia Grahmann, Jing Dong, Abigail Gregg, David Otuya, Tara Lignelli, Evan Sevieri, Joseph Gardecki, Guillermo Tearney

Proceedings Volume PC11937, PC119370O (2022) https://doi.org/10.1117/12.2612623

KEYWORDS: Intestine, Safety, Endomicroscopy, Image segmentation, In vivo imaging, Abdomen

Read Abstract +

Proceedings Article | 7 March 2022 Presentation

Presentation

OCT image guidance for gastrointestinal endoscopic cryobiopsy

Radhika Poduval, David Otuya, Shoumik Lodh, Seth Judson, Darina Postupaka, Abigail Gregg, Guillermo Tearney

Proceedings Volume PC11937, PC119370I (2022) https://doi.org/10.1117/12.2612714

KEYWORDS: Optical coherence tomography, Tissues, Endoscopy, Biopsy, Visualization, Tissue optics, Image segmentation

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Non-invasive tethered capsule endomicroscopy imaging biomarkers for the diagnosis of the celiac disease from unsedated patients

Girish G. N., Paola A. Leon Alarcon, Amilcar Barrios, David O. Otuya, Jing Dong, Sarah Giddings, Nitasha Mudalaje, Catriona Grant, Joseph Gardecki, Norman Nishioka, Christopher Damman, Guillermo Tearney

Proceedings Volume 11620, 1162003 (2021) https://doi.org/10.1117/12.2584550

Read Abstract +

Proceedings Article | 5 March 2021 Poster + Presentation

Poster + Presentation

Tethered capsule endomicroscopy-guided sampling of pancreatic fluid

Victoria Gonzalez-Canalle, David Otuya, Joseph Gardecki, Jing Dong, Guillermo Tearney

Proceedings Volume 11620, 116200G (2021) https://doi.org/10.1117/12.2583650

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Location-aware optical coherent tomography (OCT) tethered capsule endomicroscopy (TCE) of the small intestine

Du-Ri Song, David Odeke Otuya, Markus Herrmann, Camille Cunin, Patricia Grahmann, Mikayla Farham Tinus, Sarah Lynn Giddings, Guillermo Tearney

Proceedings Volume 11620, 1162006 (2021) https://doi.org/10.1117/12.2582910

KEYWORDS: Optical coherence tomography, Intestine, Endomicroscopy, Tomography, Data modeling, Machine learning, Imaging devices, Algorithm development, Pathology, Inflammation

Read Abstract +

SPIE Journal Paper | 10 February 2021 Open Access

Open Access

Improved sensitivity roll-off in dual reference, buffered spectral-domain optical coherence tomography

David Otuya, Yogesh Verma, Romain Luu, Hamid Farrokhi, Guillermo Tearney

JBO, Vol. 26, Issue 02, 025001, (February 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.2.025001

KEYWORDS: Interferometers, Optical coherence tomography, Imaging systems, In vivo imaging, Colon, Spectroscopy, Tissues, Ranging, Range imaging, Tissue optics

Read Abstract +

Proceedings Article | 4 March 2019 Presentation

Presentation

Minimally invasive trans-nasal biopsy of the small intestine (Conference Presentation)

David Otuya, Hamid Farrokhi, Jing Dong, Rachel Shore, Mason Schellenberg, Sarah Giddings, Nitasha Mudalaje, Catriona Grant, Aaron Baillargeon, Joseph Gardecki, Norman Nishioka, Christopher Damman, Guillermo Tearney

Proceedings Volume 10854, 108540M (2019) https://doi.org/10.1117/12.2510447

KEYWORDS: Biopsy, Intestine, Endoscopy, Optical coherence tomography, Metals, Absorption, Diagnostics, Gold, In vivo imaging, Tissues

Read Abstract +

Proceedings Article | 4 March 2019 Presentation

Presentation

Transnasal introduction catheter, a new platform for imaging and biopsying the gastrointestinal (GI) tract (Conference Presentation)

Hamid Farrokhi, Jing Dong, David Otuya, Yogesh Verma, Sarah Zemlok, Aditya Kumar, Rachel Shore, Sarah L. Giddings, Nitasha G. Bhat, Omair Shakil, Catriona Grant, Norman Nishioka, Mireille Rosenberg, Christopher Damman, Guillermo Tearney

Proceedings Volume 10854, 108540L (2019) https://doi.org/10.1117/12.2510381

KEYWORDS: Endoscopy, Biopsy, Optical coherence tomography, Stomach, Endomicroscopy, Tissues, Visualization, Francium, Real time imaging, Liquids

Read Abstract +

Proceedings Article | 4 March 2019 Presentation

Presentation

Duodenal imaging by tethered capsule OCT endomicroscopy in adolescents with environmental enteric dysfunction (Conference Presentation)

Jing Dong, Kamran Sadiq, Catriona Grant, Omair Shakil, David Otuya, Hamid Farrokhi, Anna Gao, Nitasha Bhat, Sarah Giddings, Kumail Ahmed, Seema Rani, Mireille Rosenberg, Alessio Fasano, Christopher Damman, Asad Ali, Guillermo Tearney

Proceedings Volume 10854, 1085408 (2019) https://doi.org/10.1117/12.2513965

KEYWORDS: Optical coherence tomography, Endomicroscopy, Intestine, Endoscopy, Inflammation, Biopsy, 3D image processing, Visualization, Control systems

Read Abstract +

Environmental Enteric Dysfunction (EED) is a poorly understood condition of the small intestine that is prevalent in regions of the world with inadequate sanitation and hygiene. EED affects 25% of all children globally and causes over a million deaths each year. The condition is associated with increased intestinal permeability, bacterial translocation, inflammation and villous blunting. The loss of absorptive area and intestinal function leads to nutrient malabsorption, with long term outcomes characterized by stunted growth and neurocognitive development. Currently, the only way to directly evaluate the morphology of the intestine is endoscopy with mucosal biopsy. Yet because EED is endemic in low and middle-income countries, endoscopy is untenable for studying EED. As a result, the diagnosis of EED and the assessment of the efficacy of EED interventions is hampered by an inability to evaluate the intestinal mucosa. Our lab has previously developed a technology termed tethered capsule OCT endomicroscopy (TCE). The method involves swallowing an optomechanically-engineered pill that generates 3D images of the GI tract as it traverses the lumen of the organ via peristalsis, assisted by gravity. In order to study the potential of using TCE to investigate EED, we initiated and conducted a TCE study in adolescents at Aga Khan Medical Center in Pakistan. To make swallowing easier, the tethered capsule’s size was reduced from 11x25 mm to 8x22 mm. Villous morphologic visualization was enhanced by building a notch (x mm deep, y mm wide) in the capsule’s imaging window. To date, 26 Pakistani subjects with ages ranging from 14 to 18 y/o (16.4 +/- 1.0) have been enrolled and imaged. A total of 19 subjects were able to swallow the capsule. Of those, 9 successfully passed through the pylorus, allowing successful microscopic imaging of the entire duodenum. There were no adverse events in any of the cases. Maximum villous height and width were measured from 3 randomly chosen, representative frames from each Pakistan subject as well as a matching number from US controls. Preliminary results, comparing Pakistani vs US villous morphology, indicated that subjects from Pakistan have shorter (628.6 +/- 22.0 um and 492.3 +/- 13.2 um, respectively, p< 0.0001) and wider duodenal villi (244.9 +/- 8.8 um and 293.4 +/- 13.2 um, respectively, p< 0.0001). These findings suggest that OCT TCE of the duodenum may be a useful tool for evaluating villous morphology in EED.

Proceedings Article | 14 March 2018 Presentation

Presentation

Trans-nasal OCT imaging of the small intestine (Conference Presentation)

David Otuya, Yogesh Verma, Jing Dong, Hamid Farrokhi, Sarah Giddings, Nitasha G. Bhat, Omair Shakil, Catriona Grant, Guillermo Tearney

Proceedings Volume 10470, 104700Z (2018) https://doi.org/10.1117/12.2290732

KEYWORDS: Optical coherence tomography, Intestine, Coherence imaging, Francium, Imaging devices

Read Abstract +

Proceedings Article | 19 April 2017 Presentation

Presentation

Feasibility study of Tethered Capsule Endomicroscopy (TCE) deployment in the small intestine (Conference Presentation)

David Otuya, Yogesh Verma, Jing Dong, Michalina Gora, Guillermo Tearney

Proceedings Volume 10040, 100400C (2017) https://doi.org/10.1117/12.2253404

KEYWORDS: Current controlled current source, Endoscopy, Endomicroscopy, Intestine, Esophagus, Microscopy

Read Abstract +

Showing 5 of 16 publications

SIGN IN TO:

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Advertisement

Advertisement