Action potential block in neurons by infrared light

Alex J. Walsh; Gleb P. Tolstykh; Stacey Martens; Bennett L. Ibey; Hope T. Beier

doi:10.1117/1.NPh.3.4.040501

1 December 2016 Action potential block in neurons by infrared light

Alex J. Walsh, Gleb P. Tolstykh, Stacey Martens, Bennett L. Ibey, Hope T. Beier

Author Affiliations +

Neurophotonics, Vol. 3, Issue 4, 040501 (December 2016). https://doi.org/10.1117/1.NPh.3.4.040501

Abstract

Short infrared laser pulses (SILP) have many physiological effects on cells, including the ability to stimulate action potentials (APs) in neurons. Here, we show that SILPs can also reversibly block APs. Reversible AP block in hippocampal neurons was observed following SILP (0.26 to 0.96 J/cm²; 1.37 to 5.01 ms; 1869 nm) with the block persisting for more than 1 s with exposures greater than 0.69 J/cm². AP block was sustained for 30 s with SILPs pulsed at 1 to 7 Hz. Full recovery of neuronal activity was observed 5 to 30 s post SILP exposure. These results indicate that SILP can be used for noncontact, reversible AP block. Due to the high spatial precision and noncontact manner of infrared light delivery, AP block by SILP (infrared neural inhibition) has the potential to transform medical care for sustained pain inhibition and suppression of unwanted nerve activity.

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Alex J. Walsh, Gleb P. Tolstykh, Stacey Martens, Bennett L. Ibey, and Hope T. Beier "Action potential block in neurons by infrared light," Neurophotonics 3(4), 040501 (1 December 2016). https://doi.org/10.1117/1.NPh.3.4.040501

Published: 1 December 2016

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KEYWORDS

Neurons

Infrared radiation

Luminescence

Thermography

Action potentials

Optogenetics

3D modeling

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