Predicting recurrence risks in lung cancer patients using multimodal radiomics and random survival forests

Jaryd R. Christie; Omar Daher; Mohamed Abdelrazek; Perrin E. Romine; Richard A. Malthaner; Mehdi Qiabi; Rahul Nayak; Sandy Napel; Viswam S. Nair; Sarah A. Mattonen

doi:10.1117/1.JMI.9.6.066001

8 November 2022 Predicting recurrence risks in lung cancer patients using multimodal radiomics and random survival forests

Jaryd R. Christie, Omar Daher, Mohamed Abdelrazek, Perrin E. Romine, Richard A. Malthaner, Mehdi Qiabi, Rahul Nayak, Sandy Napel, Viswam S. Nair, Sarah A. Mattonen

Author Affiliations +

Journal of Medical Imaging, Vol. 9, Issue 6, 066001 (November 2022). https://doi.org/10.1117/1.JMI.9.6.066001

Abstract

Purpose

We developed a model integrating multimodal quantitative imaging features from tumor and nontumor regions, qualitative features, and clinical data to improve the risk stratification of patients with resectable non-small cell lung cancer (NSCLC).

Approach

We retrospectively analyzed 135 patients [mean age, 69 years (43 to 87, range); 100 male patients and 35 female patients] with NSCLC who underwent upfront surgical resection between 2008 and 2012. The tumor and peritumoral regions on both preoperative CT and FDG PET-CT and the vertebral bodies L3 to L5 on FDG PET were segmented to assess the tumor and bone marrow uptake, respectively. Radiomic features were extracted and combined with clinical and CT qualitative features. A random survival forest model was developed using the top-performing features to predict the time to recurrence/progression in the training cohort (n = 101), validated in the testing cohort (n = 34) using the concordance, and compared with a stage-only model. Patients were stratified into high- and low-risks of recurrence/progression using Kaplan–Meier analysis.

Results

The model, consisting of stage, three wavelet texture features, and three wavelet first-order features, achieved a concordance of 0.78 and 0.76 in the training and testing cohorts, respectively, significantly outperforming the baseline stage-only model results of 0.67 (p < 0.005) and 0.60 (p = 0.008), respectively. Patients at high- and low-risks of recurrence/progression were significantly stratified in both the training (p < 0.005) and the testing (p = 0.03) cohorts.

Conclusions

Our radiomic model, consisting of stage and tumor, peritumoral, and bone marrow features from CT and FDG PET-CT significantly stratified patients into low- and high-risk of recurrence/progression.

Citation Download Citation

Jaryd R. Christie, Omar Daher, Mohamed Abdelrazek, Perrin E. Romine, Richard A. Malthaner, Mehdi Qiabi, Rahul Nayak, Sandy Napel, Viswam S. Nair, and Sarah A. Mattonen "Predicting recurrence risks in lung cancer patients using multimodal radiomics and random survival forests," Journal of Medical Imaging 9(6), 066001 (8 November 2022). https://doi.org/10.1117/1.JMI.9.6.066001

Received: 13 May 2022; Accepted: 12 October 2022; Published: 8 November 2022

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