Novel image analysis method for in situ monitoring the particle size distribution of batch crystallization processes

Benoit Presles; Johan Debayle; Gilles Fevotte; Jean-Charles Pinoli

doi:10.1117/1.3462800

1 July 2010 Novel image analysis method for in situ monitoring the particle size distribution of batch crystallization processes

Benoit Presles, Johan Debayle, Gilles Fevotte, Jean-Charles Pinoli

Author Affiliations +

Journal of Electronic Imaging, Vol. 19, Issue 3, 031207 (July 2010). https://doi.org/10.1117/1.3462800

Abstract

This article presents a new in situ method to monitor the particle size distribution (PSD) during batch solution crystallization processes. Using a new in situ imaging probe, the "EZProbe sensor," real time acquisition of 2-D images of particles during the batch process is now possible. To analyze these images, a novel image analysis method is carried out. First, segmentation and restoration algorithms are performed to identify the particles and thereafter geometrical particle measurements are achieved to obtained the PSD of the batch crystallization process over time. Satisfactory measurements are obtained provided that the overall solid concentration does not exceed a threshold above which too many overlapping crystals make discrimination between particles impossible.

©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Benoit Presles, Johan Debayle, Gilles Fevotte, and Jean-Charles Pinoli "Novel image analysis method for in situ monitoring the particle size distribution of batch crystallization processes," Journal of Electronic Imaging 19(3), 031207 (1 July 2010). https://doi.org/10.1117/1.3462800

Published: 1 July 2010

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