In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography

Barry Cense; Teresa C. Chen; Boris Hyle Park; Mark C. Pierce; Johannes F. de Boer

doi:10.1117/1.1627774

1 January 2004 In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography

Barry Cense, Teresa C. Chen, Boris Hyle Park, Mark C. Pierce, Johannes F. de Boer

Author Affiliations +

Journal of Biomedical Optics, Vol. 9, Issue 1, (January 2004). https://doi.org/10.1117/1.1627774

Glaucoma causes damage of the nerve fiber layer, which may cause loss of retinal birefringence. Therefore, PS-OCT is a potentially useful technique for the early detection of glaucoma. We built a fiber-based PS-OCT setup that produces real-time images of the human retina in vivo, coregistered with retinal video images of the location of PS-OCT scans. Preliminary measurements of a healthy volunteer show that the double-pass phase retardation per unit of depth of the RNFL is not constant and varies with location, with values between 0.18 and 0.37 deg/µm. A trend in the preliminary measurements shows that the nerve fiber layer located inferior and superior to the optic nerve head is more birefringent than the thinner layer of nerve fiber tissue in the temporal and nasal regions.

©(2004) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

Barry Cense, Teresa C. Chen, Boris Hyle Park, Mark C. Pierce, and Johannes F. de Boer "In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography," Journal of Biomedical Optics 9(1), (1 January 2004). https://doi.org/10.1117/1.1627774

Published: 1 January 2004

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
5 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

CITATIONS

Cited by 108 scholarly publications and 41 patents.

Explore citations on Lens.org

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Birefringence

Polarization

Nerve

Retina

Optical coherence tomography

Tissue optics

Head

Show All Keywords

RELATED CONTENT

Depth resolved birefringence imaging of the primate retinal nerve fiber...
Proceedings of SPIE (June 13 2002)

Imaging the primate retina using polarization-sensitve optical coherence tomography
Proceedings of SPIE (June 07 2001)

In vivo depth resolved birefringence measurements of the human retinal...
Proceedings of SPIE (July 01 2004)

In vivo depth resolved birefringence measurements of the human retinal...
Proceedings of SPIE (July 14 2003)

Analysis of birefringent image in the retinal nerve fiber layer...
Proceedings of SPIE (July 13 2004)

In vivo depth resolved birefringence measurements of the human retinal...
Proceedings of SPIE (July 08 2003)

In-vivo depth-resolved birefringence measurements of the human retina
Proceedings of SPIE (June 13 2002)

Subscribe to Digital Library

Receive Erratum Email Alert

Show All Keywords

Keywords/Phrases

Search In:

Publication Years