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1 July 1999 Spectral analysis of the porphyrins incorporation into human blood
Rodica-Mariana Ion
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Journal of Biomedical Optics, Vol. 4, Issue 3, (July 1999). https://doi.org/10.1117/1.429933
The porphyrins seem to be the most effective photosensitizers in photodynamic therapy of cancer. Monomers and dimers of sulfonated and nonsulfonated porphyrins [5,10,15,20-tetra-phenyl-porphyrin, 5,10,15,20-tetranaphtyl- porphyrin (TNP), 5,10,15,20-tetra-p-sulfonato-phenyl-porphyrin (TS4PP) and 5,10,15,20-tetra-psulfonato- naphtyl-porphyrin], are studied in this paper by means of different spectral methods (UV-vis, fluorescence and polarization fluorescence). The porphyrins as TNP seem to be the most effective photosensitizer especially in a DMSO:water binary mixture of solvent. Monomer–dimer and J-aggregation equilibria and the temperature dependence of TS4PP spectra are also studied in this paper. The incorporation of the forms of these porphyrins into blood cells is studied by means of the cytofluorimetric method.
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Rodica-Mariana Ion "Spectral analysis of the porphyrins incorporation into human blood," Journal of Biomedical Optics 4(3), (1 July 1999). https://doi.org/10.1117/1.429933
Published: 1 July 1999
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KEYWORDS
Luminescence
Absorption
Polarization
Blood
Binary data
Photodynamic therapy
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