In vivo characterization of light scattering properties of human skin in the 475- to 850-nm wavelength range in a Swedish cohort

Hanna Jonasson; Ingemar Fredriksson; Sara Bergstrand; Carl Johan Östgren; Marcus Larsson; Tomas Strömberg

doi:10.1117/1.JBO.23.12.121608

28 September 2018 In vivo characterization of light scattering properties of human skin in the 475- to 850-nm wavelength range in a Swedish cohort

Hanna Jonasson, Ingemar Fredriksson, Sara Bergstrand, Carl Johan Östgren, Marcus Larsson, Tomas Strömberg

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Journal of Biomedical Optics, Vol. 23, Issue 12, 121608 (September 2018). https://doi.org/10.1117/1.JBO.23.12.121608

Abstract

We have determined in vivo optical scattering properties of normal human skin in 1734 subjects, mostly with fair skin type, within the Swedish CArdioPulmonary bioImage Study. The measurements were performed with a noninvasive system, integrating spatially resolved diffuse reflectance spectroscopy and laser Doppler flowmetry. Data were analyzed with an inverse Monte Carlo algorithm, accounting for both scattering, geometrical, and absorbing properties of the tissue. The reduced scattering coefficient was found to decrease from 3.16 ± 0.72 to 1.13 ± 0.27 mm−1 (mean ± SD) in the 475- to 850-nm wavelength range. There was a negative correlation between the reduced scattering coefficient and age, and a significant difference between men and women in the reduced scattering coefficient as well as in the fraction of small scattering particles. This large study on tissue scattering with mean values and normal variation can serve as a reference when designing diagnostic techniques or when evaluating the effect of therapeutic optical systems.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Hanna Jonasson, Ingemar Fredriksson, Sara Bergstrand, Carl Johan Östgren, Marcus Larsson, and Tomas Strömberg "In vivo characterization of light scattering properties of human skin in the 475- to 850-nm wavelength range in a Swedish cohort," Journal of Biomedical Optics 23(12), 121608 (28 September 2018). https://doi.org/10.1117/1.JBO.23.12.121608

Received: 29 June 2018; Accepted: 31 August 2018; Published: 28 September 2018

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